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3篇 您的检索式:作者名="David C.Hughes"
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1A solution scan of societal options to reduce transmission and spread of respiratory viruses:SARS-CoV-2 as a case study显示文摘Societal biosecurity–measures built into everyday society to minimize risks from pests and diseases–is an important aspect of managing epidemics and pandemics.We aimed to identify societal options for reducing the transmission and spread of respiratory viruses.We used SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)as a case study to meet the immediate need to manage the COVID-19 pandemic and eventually transition to more normal societal conditions,and to catalog options for managing similar pandemics in the future.We used a‘solution scanning’approach.We read the literature;consulted psychology,public health,medical,and solution scanning experts;crowd-sourced options using social media;and collated comments on a preprint.Here,we present a list of 519 possible measures to reduce SARS-CoV-2 transmission and spread.We provide a long list of options for policymakers and businesses to consider when designing biosecurity plans to combat SARS-CoV-2 and similar pathogens in the future.We also developed an online application to help with this process.We encourage testing of actions,documentation of outcomes,revisions to the current list,and the addition of further options.William J.Sutherland Nigel G.Taylor David C.Aldridge Philip Martin Catherine Rhodes Gorm Shackelford Simon Beard Haydn Belfield Andrew J.Bladon Cameron Brick Alec P.Christie Andrew P.Dobson Harriet Downey Amelia S.C.Hood Fangyuan Hua Alice C.Hughes Rebecca M.Jarvis Douglas MacFarlane William H.Morgan Anne-ChristineMupepele Stefan J.Marciniak Cassidy Nelson SeánÓhÉigeartaigh Clarissa Rios Rojas Katherine A.Sainsbury Rebecca K.Smith Lalitha S.Sundaram Ann Thornton John Watkins Thomas B.White Kate Willott Silviu O.Petrovan 2021Journal of Biosafety and Biosecurity2021,3,2:0
2Genetic Testing in Professional Football:Perspectives of Key Stakeholders显示文摘Purpose Genetic research in football is currently in it’s infancy but is growing rapidly.However,the practical application of genetic testing in football and the views concerning its use are unknown.Thus,the purpose of this study was to assess the current practical application of genetic testing in professional football and provide an insight into the perspectives of key stakeholders(i.e.,coaches,practitioners,players).Methods In total,122 participants completed an online anonymous survey.This consisted of 21 multiple choice and Likert scale questions,with the option of providing an explanation for each response.Results Findings revealed genetic testing is rarely utilised by key stakeholders(10%)or their respective organisations(14%).However,three quarters(75%)had the opinion that genetic testing will have great utility in the future.The majority(72%)believed genetic testing should be used for athlete development and injury risk,whilst 35%believed that genetic testing should be utilised for talent identification purposes.However,most key stakeholders viewed their own(89%)and their col-leagues’(79%)knowledge related to genetic testing as insufficient;mainly due to ineffective current communication methods(91%).Most believed educational workshops are required(71%),whilst nearly all(91%)were interested in developing their expertise on the utility of genetic testing.Conclusion Genetic testing is rarely used within professional football,although key stakeholders anticipate that it will be utilised more in the future.As such,educational support may prove valuable in improving key stakeholder knowledge and the practical application of genetic testing in professional football.Alexander B.T.McAuley David C.Hughes Loukia G.Tsaprouni Ian Varley Bruce Suraci homas R.Roos Adam J.Herbert Adam L.Kelly 2022Journal of Science in Sport and Exercise2022,4,1:0
3A Systematic Review of the Genetic Predisposition to Injury in Football显示文摘Purpose Synthesise genetic association studies investigating injury involving football players to identify which genetic variants have the most empirical evidence to date.Methods A comprehensive search of the PubMed,SPORTDiscus,and MEDLINE databases until March 11th 2022 identi-fied 34 studies.Inclusion criteria:primary investigations,included football players,examined the association of a genetic variant with injury,and were published in English.Risk of bias was assessed using the Newcastle–Ottawa Scale.A narrative synthesis summarised results.Results There were 33 candidate gene studies and one genome-wide study,with 9642 participants across all studies(range=43–1311;median=227).Ninety-nine polymorphisms were assessed within 63 genes.Forty-one polymorphisms were associated with injury once.Three polymorphisms had their specific allelic associations with injury replicated twice in independent cohorts:ACTN3(rs1815739)XX genotype was associated with an increased susceptibility to non-contact muscle injuries,ACAN(rs1516797)G allele was associated with increased susceptibility to anterior cruciate ligament(ACL)injuries,and VEGFA(rs2010963)CC genotype was associated with an increased susceptibility to ACL and ligament or tendon injuries.However,several methodological issues(e.g.,small sample sizes,cohort heterogeneity,and population stratification)are prevalent that limit the reliability and external validity of findings.Conclusion At present,the evidence base supporting the integration of genetic information as a prognostic or diagnosis tool for injury risk in football is weak.Future participation of organisations in international consortia is suggested to combat the current methodological issues and subsequently improve clarity concerning the underlying genetic contribution to injury susceptibility.Alexander B.T.McAuley David C.Hughes Loukia G.Tsaprouni Ian Varley Bruce Suraci Thomas R.Roos Adam J.Herbert Daniel T.Jackson Adam L.Kelly 2023Journal of Science in Sport and Exercise2023,5,2:0
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