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您的检索式：作者名="David R.Hinton"
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| 1 | Sodium iodate induced retinal degeneration: new insights from an old model显示文摘Studies on the selective retinal degeneration induced by sodium iodate(Na IO3)date back to 1941;Sorsby(1941)described the effect of intravenously injected Na IO3solution on the rabbit retina.Since then,Na IO3-induced retinal degeneration has been described in different mammalian species including sheep,rabbit,rat and mouse with varying doses and routes of administration.At the present time,the murine Na IO3model is the most widely used because it results in reproducible,patchy retinal degeneration(Figure 1)and can be studied in a wide variety of wild type and genetic knockout strains. | Ram Kannan David R.Hinton | 2014 | Neural Regeneration Research2014，9，23： | 7 |
| 2 | Endoplasmic reticulum-mitochondrial crosstalk:a novel role for the mitochondrial peptide humanin显示文摘In this review,the interactive mechanisms of mitochondria with the endoplasmic reticulum(ER) are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin(HN) in ER stress.The ER and mitochondria are dynamic organelles capable of modifying their structure and function in response to changing environmental conditions.The ER and mitochondria join together at multiple sites and form mitochondria-ER associated membranes that participate in signal transduction pathways that are under active investigation.Our laboratory previously showed that HN protects cells from oxidative stress induced cell death and more recently,described the beneficial role of HN on ER stress-induced apoptosis in retinal pigment epithelium cells and the involvement of ER-mitochondrial cross-talk in cellular protection.The protection was achieved,in part,by the restoration of mitochondrial glutathione that was depleted by ER stress.Thus,HN may be a promising candidate for therapy for diseases that involve both oxidative and ER stress.Developing novel approaches for retinal delivery of HN,its analogues as well as small molecular weight ER stress inhibitors would prove to be a valuable approach in the treatment of age-related macular degeneration. | Parameswaran G.Sreekumar David R.Hinton Ram Kannan | 2017 | Neural Regeneration Research2017，12，1： | 5 |
| 3 | 白介素2α受体在人视网膜色素上皮细胞中的表达(英文)显示文摘目的 研究白介素2α受体(IL-2Rα)在人视网膜色素上皮(RPE)细胞中的表达及白介素2(IL-2)对RPE细胞增生的影响。方法收集培养的2~4代的人胚胎RPE细胞,应用RT-PCR技术,用IL-2α受体特异引物对IL-2α受体进行检测,应用荧光激活细胞分类技术检测IL-2的结合。用抗CD25抗体的免疫荧光染色法识别IL-2α受体的表达,通过^3H摄取技术评估重组IL-2对RPE细胞增生的影响。结果 RPE细胞可表达IL-2Rα mRNA,免疫荧光染色和IL-2结合试验也可表明IL-2α受体的表达,高浓度的IL-2可诱导RPE细胞的增生(P〈0.05)。结论 培养的RPE细胞能够表达IL-2α受体,重组IL-2可促进RPE细胞的增生。 | 何世坤 David R.Hinton | 2006 | 眼科研究2006，24，5： | 0 |
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