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| 1 | 消融的冰川:加拿大班夫国家公园亚高山带鲍湖中持久性有机氯的主要来源显示文摘有机氯杀虫剂和多氯联苯(PCB)是环境中普遍而稳固的化合物。现已查明,由于它们从温暖的地区逐渐蒸发出来,并在较冷的地区凝聚下来,因而它们富集在寒冷的环境中。在本研究中,我们的结果是,消融的冰川供给阿尔伯达亚高山带湖泊中的有机氯输入量为50%~97%,而提供的水量为73%。对氚的分析结果表明,在夏季的中、晚期,至少10%的冰川消融物是在1950~1970年期间沉积下来的,这期间它受到有机氯更多的污染。这一发现表明,气候变暖可能会使消融的冰川成为日益增多的淡水污染物来源。由于有机物贫乏的冰川粘土对多氯联苯这样的疏水化合物的吸附能力有限,因此冰川水流带来的有机氯大多呈溶解状态。 | Jules M. Blais David W. Schindler Derek C. G. Muir Martin Sharp David Donald MelissaLafrenière Eric Braekevelt William M. J. Strachan 周立志 | 2001 | AMBIO-人类环境杂志2001，30，7： | 4 |
| 2 | Efficacy of selective laser trabeculoplasty following incisional glaucoma surgery显示文摘AIM: To evaluate the efficacy of selective laser trabeculoplasty(SLT) in glaucomatous eyes with previous incisional glaucoma surgery. METHODS: A retrospective cohort of eyes that underwent SLT at a single institution from 2013-2015 were followed for 1 y. Reduction in intraocular pressure(IOP) following SLT was evaluated in eyes with prior trabeculectomy with Ex Press mini shunt(Alcon, Ft Worth, TX, USA), Ahmed valve(New World Medical, Cucamonga, CA, USA), or combined phacoemulsification-trabeculectomy. A control group was included with eyes without prior surgery that underwent SLT. Success was defined as >20% drop in IOP from pre-SLT baseline. RESULTS: One-hundred and six eyes were included with 53 in both the prior glaucoma surgery(PGS) and no prior glaucoma surgery(NPGS) groups. Mean pre-SLT IOP was 19.2±4.3 and 20.6±6.0 mm Hg for PGS and NPGS groups, respectively(P=0.17). Both groups produced statistically significant IOP reductions at 1 and 6 mo(P<0.04). At 6 mo, mean IOP reduction reached 7.3% and 10.8% for the PGS and NPGS groups, respectively(P=0.42). Overall, 27.9% and 31.7% of eyes in PGS and NPGS groups met success criteria at 1 y(P=0.70). In the PGS group, eyes with baseline IOP ≥21 mm Hg had IOP reductions of 18.1%(P<0.001), 16.7%(P<0.01), and 8.4%(P=0.31) compared to eyes with baseline IOP <21 mm Hg who had IOP reductions of 2.3%(P=0.39), 3.4%(P=0.19), and 1.1%(P=0.72) at 1, 6 mo, and 1 y, respectively. CONCLUSION: SLT is efficacious in eyes with prior incisional glaucoma surgery and results in similar IOP reductions compared to eyes without PGS. A larger IOP reduction is observed following SLT in eyes with higher pre-SLT IOP. | Robert Allan Sharpe Leah L Kammerdiener David B.Williams Sudeep K.Das Matthew J.Nutaitis | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 5 | Prognostic value of baseline FDG uptake on PET-CT in esophageal carcinoma显示文摘AIM: To evaluate the influence of baseline maximum standardized uptake value(SUVmax) on survival in a cohort of patients, undergoing positron emission tomography-computed tomography(PET-CT) scan for esophageal carcinoma. METHODS: The pre-treatment SUVmax numeric reading was determined in patients with confirmed esophageal or junctional cancer having PET-CT scan during the time period 1st January 2007 until 31 st July 2012. A minimum follow up of 12 mo was required. Patients were subdivided into quartiles according to SUVmax value and the influence of SUVmax on survival was assessed using univariate and multivariate analysis. The following pre-treatment factors were investigated: patient characteristics, tumor characteristics and planned treatment. RESULTS: The study population was 271 patients(191male) with esophageal or junctional carcinoma. The median age was 65 years(range 40-85) and histologic subtype was adenocarcinoma in 197 patients and squamous carcinoma in 74 patients. The treatment intent was radical in 182 and palliative in 89 patients. SUVmax was linked to histologic subtype(P = 0.008), tumor site(P = 0.01) and Union for International Cancer Control(UICC) stage(P < 0.001). On univariate analysis, prognosis was significantly associated with SUVmax(P = 0.001), T-stage(P < 0.001) and UICC stage(P < 0.001). On multivariate analysis, only T-stage and UICC stage remained significant. CONCLUSION: Pretreatment SUVmax was not a useful marker in isolation for determining prognosis of patients with esophageal carcinoma. | Omar S Al-Taan Amar Eltweri David Sharpe Peter M Rodgers Sukhbir S Ubhi David J Bowrey | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 2 |
| 6 | The Estrogen Replacement and Atherosclerosis (ERA)Study: study design and baseline characteristics of the cohort显示文摘 | David M Herrington David M Reboussin Penny C Sharp | 2000 | Controlled Clinical Trials2000，21，： | 1 |
| 7 | Properties of air mass mixing and humidity in the subtropics from measurements of the D/H isotope ratio of water vapor at the Mauna Loa Observatory显示文摘 | Noone David Galewsky Joseph Sharp Zachary D. Worden John Barnes John Baer Doug Bailey Adriana Brown Derek P. Christensen Lance Crosson Eric Dong Feng Hurley John V. Johnson Leah R. Strong Mel Toohey Darin Pelt Aaron Van Wright Jonathon S | 2011 | Journal of Geophysical Research Atmospheres2011，，22： | 1 |
| 8 | A 10-y Monthly Lightning C1imate Florida: 1986-95显示文摘 | David Sharp Waylon Collins | 1997 | Weather and Forecasting1997，12，3： | 1 |
| 9 | Wind Energy Handbook显示文摘 | Tony Burton David Sharpe Nick Jenkins | 2001 | John Wiley & Sons Ltd2001，，： | 1 |
| 10 | Functional and structural diversity of the human Dickkopf gene family显示文摘 | Valery E. Krupnik John D. Sharp Chian Jiang Keith Robison Troy W. Chickering Lakshmi Amaravadi Diane E. Brown Deborah Guyot Gail Mays Kevin Leiby Belle Chang Thao Duong Andrew D.J. Goodearl David P. Gearing Sergei Y. Sokol Sean A. McCarthy | 1999 | Gene1999，，2： | 1 |
| 11 | Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Perforated Appendicitis: A Prospective Randomized Trial显示文摘 | Shawn D. St Peter Obinna O. Adibe Corey W. Iqbal Frankie B. Fike Susan W. Sharp David Juang David Lanning J. Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder George W. Holcomb Daniel J. Ostlie | 2012 | Annals of Surgery2012，，4： | 1 |
| 12 | Agency effects and escalation of commitment: do small national culture differences matter?显示文摘 | Stephen B Salter David J Sharp | 2001 | International Journal of Accounting2001，，1： | 1 |
| 13 | Carbon dioxide disposal in carbonate minerals显示文摘 | Klaus S. Lackner Christopher H. Wendt Darryl P. Butt Edward L. Joyce David H. Sharp | 1995 | Energy1995，，11： | 1 |
| 14 | Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses显示文摘 | Nicole Joller Ester Lozano Patrick R. Burkett Bonny Patel Sheng Xiao Chen Zhu Junrong Xia Tze G. Tan Esen Sefik Vijay Yajnik Arlene H. Sharpe Francisco J. Quintana Diane Mathis Christophe Benoist David A. Hafler Vijay K. Kuchroo | 2014 | Immunity2014，，4： | 1 |
| 15 | The effectiveness of routine-based decision processes:the case of international pricing显示文摘 | SHARP DAVID J | | 0，，1： | 1 |
| 16 | 贝伐单抗在眼科的应用引起争议显示文摘在Science Watch所追踪的高被引临床论文中,极少出现眼科领域的论文,但本期的热点论文4却发表于眼科期刊。黄斑变性是致盲的重要原因,该病具有年龄相关性,因此随着世界老龄化的到来,该病的重要性将会增加。其中湿性黄斑变性是更为严重的情况,因为视网膜下新血管的生长会影响视力,所以治疗该类型疾病的方法之一便是阻止新血管化。在医学研究的多个领域, | David W Sharp | 2008 | 科学观察2008，3，2： | 1 |
| 17 | Compiler transformations for high-performance computing 显示文摘 | Bacon David F Graham Susan L Sharp Oliver J | 1994 | ACM Computing Surveys1994，26，4： | 1 |
| 18 | Frequent attenders without organic disease in a gastroenterology clinic显示文摘 | Christopher Bass David Gill Michael sharp | 1999 | General Hospital Psychiatry1999，21，： | 1 |
| 19 | RNAi显示文摘 | Phillip D Zamore Thomas Tuschl Phillip A Sharp David P Bartel | 2000 | Cell2000，，1： | 1 |
| 20 | Market Structure and the Nature of Price Rigidity: Evidence from the Market for Consumer Deposits 显示文摘 | David N Sharpe SA | 1992 | Quarterly Journal of Economics1992，107，2： | 1 |
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