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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | Click chemistry as an efficient synthetic tool for the preparation of novel conjugated polymers显示文摘 | Dirk J V C David O R P Strijdonck G P E | 2005 | Chemistry Common2005，，34： | 1 |
| 4 | Heavy off-road vehicletire-pavement interactions and response 显示文摘 | Siddharthan Raj V Sebaaly Peter E Magdy El-Desouky Strand Dan Huft David | 2005 | Journal ofTransportation Engineering2005，131，3： | 1 |
| 5 | The Medicinal Plants of Uzbekistan and Kyrgyzstan显示文摘 | David E Z lgor V B Anvar G K | 2012 | Medicinal Plants of Central Asia: Uzbekistan and Kyrgyzstan2012，，7： | 1 |
| 6 | Structure and physicochemistry of anodic oxide films on titanium and TA6V alloy显示文摘 | Zwilling V Darque-Ceretti E Boutry-Forveille A David D Perrin M Y Aucouturier M | | 0，，07： | 1 |
| 7 | Phosphorus Trans- port Pathways to Streams in Tile-Drained Agricultural Watersheds 显示文摘 | GENTRY L E DAVID M B ROYER T V | 2007 | Journal of Environmental Quality2007，36，2： | 1 |
| 8 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 9 | Structural insights into the mechanical regulation of molecular in Biotechnology显示文摘 | WENDY E T Trends DAVID W C | 2001 | recognition sites2001，19，10： | 1 |
| 10 | Process- ing intermetallic composites by self propagating, high-tempera- ture synthesis 显示文摘 | DAVID E A JEFFREY A H ARTHUR V P | 1994 | Journal of Metals1994，46，1： | 1 |
| 11 | Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘 | Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J | 2013 | International Journal of Environmental Research and Public Health2013，，12： | 1 |
| 12 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 13 | Correlates of depression among HIV-positive women and men who inject drugs 显示文摘 | EDUARDO V E DAVID P W DRENNA W V | 2007 | JAcquir Immune Defic Syndr2007，，： | 1 |
| 14 | Serum peptide profiling by magnetic particle -assisted, automated sample processing and MALDITOF mass spectrometry 显示文摘 | Josep V John P David E | 2004 | Anal Chem2004，76，6： | 1 |
| 15 | Time course production of urolithins from ellagic acid by human gut microbiota 显示文摘 | Rocia G V David B Juan C E | 2013 | J Agric Food Chem2013，61，： | 1 |
| 16 | Some properties of aqueous xanthan gels formed under the action ofaluminium (Ⅲ) ions 显示文摘 | Andrew B Rodd Dave E Dustan David V Boger | 2002 | Macromolecular Symposia2002，19，1： | 1 |
| 17 | A molecular phylogeny of the octopoda (Mollusca:Cephalovod a) evaluated in light of morphological evidence显示文摘 | David B Carlini R E Young M V | 2001 | Molecular Phylogenetics and Evolution2001，21，3： | 1 |
| 18 | New MUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis 显示文摘 | David V Gold David E Modrak Thomas M Cardillo | 2006 | Clinical Oncology2006，24，1： | 1 |
| 19 | Gaming manager benchmarks显示文摘 | Bailey J V Tierney David E | 1993 | Journal of Portfolio Management1993，19，4： | 1 |
| 20 | Genetic variation of CYF2CI9 affects both phamlacokinetic and phmnacodynamic responses to clopi- dogrel but not prasugrel in aspirin-treated patients with coronary artery disease显示文摘 | Christoph V Stefan J David E | 2009 | Eur Heart J2009，30，14： | 1 |
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