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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Phases of Environmental Evolution Indicated by Primary Chemical Elements and Paleontological Records in the Upper Pleistocene-Holocene Series for the Salawusu River Valley,China显示文摘岩性学的研究,沉积褪色,分发整齐 ofSiO_2 和 Al_2O_3 满足并且 Al_2O_3/SiO_2 比率允许我们划分 Milanggouwan 节在中国的 Salawusu 河山谷代表进六个片断的上面的 Pleistocene-HoloceneSeries : MGS1, MGS2, MGS3, MGS4, MGS5 和 MGS6。边界为 MGS1 ( Dishaogouwan 和 DagouwanFormations )变老, MGS2 (上面的 Chengchuan 形成), MGS3 (中间的 Chengchuan 形成), MGS4 (更低的 Chengchuan 形成),分别地, MGS5 ( Salawusu 形成的大多数阶层)和 MGS6 ( Salawusu 形成的底部和 Lishi 形成的顶)从深海沉积或大陆冰川 MIS1 , MIS2 , MIS3 , MIS4 , MIS5 和 MIS6 对应于那些。MGS5 能被细分进五子段(MGS5a, MGS5b, MGS5c, MGS5d 和 MGS5e ) ,这些子段的边界年龄分别地 MIS5a, MIS5b, MIS5c, MIS5d 和 MIS5e 对应于那些。古环境和苍白的生态学由主要化学元素,石块脊椎动物,软体动物和花粉谷物显示了的 Basedon ,我们假设 MGS5 的子段匹配的那 MGS1 , MGS2 , MGS3 , MGS4 , MGS5 和 MGS6and 为在深海沉积和大陆冰川的氧同位素的相应阶段,并且潜水艇以气候的人物, MIS5 上演进一步向现象解释那决定了晚第四级的阶层的形成和 Salawusu 的古生物学这些现象在世界气候联系到变化(并且特别地在东方亚洲季风) 在冰川、间冰期的句号期间。 | LI Baosheng WEN Xiaohao QIU Shifan David Dian ZHANG DU Shuhuan CHEN Deniu OU Xianjiao NIU Dongfeng | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 17 |
| 3 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 4 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
| 5 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 6 | Sequential and Concomitant Therapy With Four Drugs Is Equally Effective for Eradication of H pylori Infection显示文摘 | Deng–Chyang Wu Ping–I. Hsu Jeng–Yih Wu Antone R. Opekun Chao–Hung Kuo I.–Chen Wu Sophie S.W. Wang Angela Chen Wen–Chun Hung David Y. Graham | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 7 |
| 7 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 8 | Metal–Organic Framework-Assisted Synthesis of Compact Fe_2O_3 Nanotubes in Co_3O_4 Host with Enhanced Lithium Storage Properties显示文摘Transition metal oxides are promising candidates for the high-capacity anode material in lithium-ion batteries.The electrochemical performance of transition metal oxides can be improved by constructing suitable composite architectures. Herein, we demonstrate a metal–organic framework(MOF)-assisted strategy for the synthesis of a hierarchical hybrid nanostructure composed of Fe_2O_3 nanotubes assembled in Co_3O_4 host. Starting from MOF composite precursors(Fe-based MOF encapsulated in a Cobased host matrix), a complex structure of Co_3O_4 host and engulfed Fe_2O_3 nanotubes was prepared by a simple annealing treatment in air. By virtue of their structural and compositional features, these hierarchical composite particles reveal enhanced lithium storage properties when employed as anodes for lithium-ion batteries. | Song Lin Zhang Bu Yuan Guan Hao Bin Wu Xiong Wen David Lou | 2018 | Nano-Micro Letters2018，10，3： | 7 |
| 9 | Sedimentary characteristics of paleo-aeolian dune sands of Salawusu Formation in the Salawusu River Valley显示文摘在 Salawusu 河山谷的 Milanggouwan 节的 Salawusu 形成包括修理 paleo 、修理半的沙丘沙的 paleo 活动的沙丘沙,和 4 层的 7 层。他们的结构被观察了并且他们的谷物尺寸。 | OU Xianjiao LI Baosheng JIN Heling DONG Guangrong David Dian ZHANG WU Zheng WEN Xiaohao ZENG Lanhua OUYANG Chuntao YANG Yi LIU Yufei | 2008 | Journal of Geographical Sciences2008，18，2： | 6 |
| 10 | 引力波数据分析显示文摘以引力波探测为基础的引力波天文学是一门正在崛起的新兴交叉学科,它是继以电磁辐射为探测手段的传统天文学之后,人类观测宇宙的一个新窗口,对研究宇宙的起源和演化,拓展天文学的研究领域都有极其重要的意义。激光干涉引力波探测器的出现,更开辟了引力波探测的新纪元。引力波数据处理与分析己在世界各地迅速发展起来,为引力波天文学的研究提供了锐利的武器。系统地介绍了引力波数据分析中常用的工具软件,详细讨论了时间一频率分析、复合分析法、脉冲星计时分析法、匹配过滤器、模板、妒检验、蒙特卡罗模拟等引力波数据分析中使用的基本方法。 | 王小鸽 ERIC Lebigot 都志辉 曹军威 王运永 张帆 蔡永志 李木子 朱宗宏 钱进 殷聪 王建波 赵文 张扬 DAVID Blair JU Li ZHAO Chun-Nong WEN Lin-Qing | 2016 | 天文学进展2016，34，1： | 6 |
| 11 | Dispersal is associated with morphological innovation, but not increased diversification, in Cyphostemma (Vitaceae)显示文摘包括疏开,词法革新,和产地变化的多重过程经常为增加的多样化作为催化剂被引用。我们在类 Cyphostemma (Vitaceae ) 在他们之中调查这些过程和原因的连接,包括在为它生长习惯的差异的 Vitaceae 是唯一的 200 种类的 clade。我们重建 timecalibrated 在在使用五的类的 64 种类之中的进化关系原子并且叶绿体标记并且推断词法的组和 biogeographic 历史。我们测试因为在种形成的变化评估并且评估时间的协会并且用一条蒙特卡罗模拟途径关于疏开,产地变化,和词法进化事件定序。在 Cyphostemma,既不疏开也不词法进化处于种形成率与移动被联系,但是疏开在生长形式与进化移动被联系。特别地,茎多汁的进化与改编被联系到本地人,先存在在 situ 的条件列在后面 longdistance 疏开,不是产地变化。我们建议在疏开,词法革新,和多样化之间的协会的模式可以在学习下面依靠特别人物。与 evolutionarily 易变的人物一起的系例如茎多汁,未必确实遵循壁龛保守主义的观点并且相反表明显著词法改编到本地气候和土壤的条件列在后面疏开。 | David J. Hearn Margaret Evans Ben Wolf Michael McGinty Jun Wen | 2018 | Journal of Systematics and Evolution2018，56，4： | 6 |
| 12 | PEPT study of particle motion for different riser exit geometries显示文摘Laboratory and industrial risers are equipped with exits of many different layouts,and numerous publications discuss the influence of riser exit geometry on local and overall solids hydrodynamics in the riser.The present paper reviews literature findings-mostly based upon indirect experimental techniques and often somewhat contradictory.Direct measurement of particle velocity and particle occupancy near and in the riser exit provide a better indication of the effect of riser exit geometry.Positron Emission Particle Tracking(PEPT)was used in this work for the first time to investigate the exit region of the riser.An abrupt or sharp exit causes particles to be knocked out of the gas flow,so forming a recirculation or reflux region in the upper part of the riser.This is much less pronounced with a curved or gradual exit. | Chian Wen Chan Anke Brems Shiva Mahmoudi Jan Baeyens Jonathan Seville David Parker Thomas Leadbeater Joseph Gargiuli | 2010 | Particuology2010，8，6： | 5 |
| 13 | Embedding CoS2 nanoparticles in N-doped carbon nanotube hollow frameworks for enhanced lithium storage properties显示文摘 | Jintao Zhang Le Yu Xiong Wen (David) Lou | 2017 | Nano Research2017，10，12： | 5 |
| 14 | Clinical outcomes of elderly South-East Asian patients in primary percutaneous coronary intervention for ST- elevation myocardial infarction显示文摘评估临床的特征和经历主要经皮的冠的干预(PPCI ) 的老东南亚洲病人的在里面医院结果 .MethodsFrom 2009 年 1 月到 2012 年 12 月, 1268 个病人(86.4% 男性, 58.4 楴 的吝啬的年龄? | Jieli Tong Wen Wei Xiang An Shing Ang Wen Jun Sim Kien Hong Quah David Foo Paul Jau Lueng Ong Hee Hwa Ho | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 15 | 引力波与引力波源显示文摘引力波爆发事件GW150914的发现,标志着引力波天文学时代的到来,它为人类打开了全新的窗口来研究强引力场、极致密天体、极高能过程、极早期宇宙等极端物理过程和现象。介绍广义相对论中引力波的基本性质、观测效应以及主要的产生机制。并着重介绍宇宙中的几类比较重要的引力波源的主要性质、探测方法,以及探测现状和未来展望。具体包括:旋转的中子星、稳定的双星系统等连续的引力波源,超新星爆发、双星并合等爆发式的引力波源,以及天体物理过程和宇宙暴胀产生的随机引力波背景。 | 赵文 张星 刘小金 张杨 王运永 张帆 肇宇航 郭越凡 陈奕康 艾舜柯 朱宗宏 WANG Xiao-ge LEBIGOT Eric 都志辉 曹军威 钱进 殷聪 王建波 BLAIR David JU Li ZHAO Chun-nong WEN Lin-qing | 2017 | 天文学进展2017，35，3： | 4 |
| 16 | Paleoclimate change recorded in the red earth and brown-yellow sediment of Late Quaternary for northeastern part of Guangdong Province,south to the Nanling Mountains,China显示文摘The paleoenvironment indicated by the geochronology,major oxides——SiO2,Al2O3 and TOFE(Fe2O3 + FeO),and CIA(Chemical Index of Alteration) value of the red earth and brown-yellow silt primarily characterized by the Linjiang stratigraphic section,based on the geological investigation of Late Quaternary along the river banks of northeastern part of China's Guangdong Province,south to the Nanling Mountains,allow us to hypothesize that the red earth on the first terrace in northeastern part of Guangdong belongs to reticulated red clay developed in a hot-wet environment of the last interglacial period(132―73 ka BP),similar to the monsoon environment in the northern margin of modern tropical zone,while the overlying brown-yellow silt layer mainly accumulated in a monsoon environment of warm temperate zone in the last glacial period(73―11 ka BP),with the aeolian sand LJ3 representing an extreme period of worsening climate.Such a hypothesis corresponds well with predecessors' research on the paleoenvironment indicated by abundant fossils in both south and east to the Nanling Mountains.Hence,it follows that the bioclimatic zone did experience a large and rapid vicissitude in northeastern part of China's Guangdong Province,and even in the full extent of the region south to the Nanling Mountains from the last interglacial period to the last glacial period,with the red earth being replaced by the brown-yellow silty sediment,and even maybe with the Ailuropoda-Stegodon Fauna being replaced by the Penghu Fauna.This study may provide an important geological demonstration for the environmental response to global change in China's low latitudes on a 10 ka scale. | LI BaoSheng WEN XiaoHaoi DAVID DianZhang QIU ShiFan DONG YOXiang LI ZhiWen DU ShuHuan OU XianJiao LI HouXin NIU DongFeng YANG Yi | 2008 | Chinese Science Bulletin2008，53，24： | 4 |
| 17 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 18 | Specialising neural network potentials for accurate properties and application to the mechanical response of titanium显示文摘Large scale atomistic simulations provide direct access to important materials phenomena not easily accessible to experiments or quantum mechanics-based calculation approaches.Accurate and efficient interatomic potentials are the key enabler,but their development remains a challenge for complex materials and/or complex phenomena.Machine learning potentials,such as the Deep Potential(DP)approach,provide robust means to produce general purpose interatomic potentials.Here,we provide a methodology for specialising machine learning potentials for high fidelity simulations of complex phenomena,where general potentials do not suffice.As an example,we specialise a general purpose DP method to describe the mechanical response of two allotropes of titanium(in addition to other defect,thermodynamic and structural properties).The resulting DP correctly captures the structures,energies,elastic constants andγ-lines of Ti in both the HCP and BCC structures,as well as properties such as dislocation core structures,vacancy formation energies,phase transition temperatures,and thermal expansion.The DP thus enables direct atomistic modelling of plastic and fracture behaviour of Ti.The approach to specialising DP interatomic potential,DPspecX,for accurate reproduction of properties of interest“X”,is general and extensible to other systems and properties. | Tongqi Wen Rui Wang Lingyu Zhu Linfeng Zhang Han Wang David J.Srolovitz Zhaoxuan Wu | 2021 | npj Computational Materials2021，，1： | 3 |
| 19 | HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs显示文摘Genome-edited human induced pluripotent stem cells(iPSCs)hold great promise for therapeutic applications.However,low editing efficiency has hampered the applications of CRISPR-Cas9 technology in creating knockout and homology-directed repair(HDR)-edited iPSC lines,particularly for silent genes.This is partially due to chromatin compaction,inevitably limiting Cas9 access to the target DNA.Among the six HDAC inhibitors we examined,vorinostat,or suberoylanilide hydroxamic acid(SAHA),led to the highest HDR efficiency at both open and closed loci,with acceptable toxicity.HDAC inhibitors equally increased non-homologous end joining(NHEJ)editing efficiencies(~50%)at both open and closed loci,due to the considerable HDAC inhibitor-mediated increase in Cas9 and sgRNA expression.However,we observed more substantial HDR efficiency improvement at closed loci relative to open chromatin(2.8 vs.1.7-fold change).These studies provide a new strategy for HDRediting of silent genes in iPSCs. | Jian-Ping Zhang Zhi-Xue Yang Feng Zhang Ya-Wen Fu Xin-Yue Dai Wei Wen Beldon Zhang Hannah Choi Wanqiu Chen Meredith Brown David Baylink Lei Zhang Hongyu Qiu Charles Wang Tao Cheng Xiao-Bing Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 20 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
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