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1篇 您的检索式:作者名="Deborah Decrop"
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1Reaction injection molding of hydrophilicin-hydrophobic femtolitre-well arrays显示文摘Patterning of micro-and nanoscale topologies and surface properties of polymer devices is of particular importance for a broad range of life science applications,including cell-adhesion assays and highly sensitive bioassays.The manufacturing of such devices necessitates cumbersome multiple-step fabrication procedures and results in surface properties which degrade over time.This critically hinders their wide-spread dissemination.Here,we simultaneously mold and surface energy pattern microstructures in off-stoichiometric thiol-ene by area-selective monomer selfassembly in a rapid micro-reaction injection molding cycle.We replicated arrays of 1,843,650 hydrophilic-inhydrophobic femtolitre-wells with long-term stable surface properties and magnetically trapped beads with 75%and 87.2%efficiency in single-and multiple-seeding events,respectively.These results form the basis for ultrasensitive digital biosensors,specifically,and for the fabrication of medical devices and life science research tools,generally.Reza Zandi Shafagh Deborah Decrop Karen Ven Arno Vanderbeke Robert Hanusa Jolien Breukers Gaspard Pardon Tommy Haraldsson Jeroen Lammertyn Wouter van der Wijngaart 2019Microsystems & Nanoengineering2019,5,1:0
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