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| 1 | Cellular and Molecular Immunopathogenesis of Ulcerative Colitis显示文摘Ulcerative 大肠炎(UC ) 是直肠、结肠的 mucosa 的煽动性的疾病并且似乎源于在危险性基因,环境和免疫系统之间的相互作用的一个复杂系列。mucosal 免疫系统的各种各样的部件在 UC 的 immunopathogenesis 被含有。从动物模型的证据也建议对宿主的共栖的 microflora 的改变的有免疫力的回答在 UC 的发展起一个中央作用。那么在这评论,我们阐明从四个方面在疾病的 immunopathogenesis 被含有的房间和分子:在肠的抗原,树枝状的房间,在 UC 敲相似受体和 NF-B。 | Suzhen Zhang Xuhui Zhao Dechun Zhang | 2006 | Cellular & Molecular Immunology2006，3，1： | 25 |
| 2 | Profile Characteristics and Potential EnvironmentalEffect of Accumulated Phosphorus in Soils of Vegetable Fields in Beijing显示文摘Profile characteristics of accumulated P in 10 representative soils of vegetable fields in suburban districtsof Beijing were investigated. Bioavailability of the accumuIated P and its potential effect on the environmentwere studied in a greenhouse pot experiment and a soil column experiment. The results showed that theconcentration of Olsen-P in the 0-20 cm soil samples of the vegetable fields ranged from 22.1 to 358.0 mgkg-1, which was 2 to 10 times higher than that of the crop fields in the suburbs of Beijing. Most of theexcessive phosphorus was accumulated in the topsoils. The longer the soils cultivated with vegetables, thehigher the soil total P, Olsen-P and organic matter concentration. Accumulated P in the soils from vegetablefields had higher bioavailability. Application of phosphorus fertilizer could not increase the dry weights ofcucumbers, Chinese cabbage, and rape seedlings continuously planted. The soil column study showed highP concentration (> 0.6 mg L-1) in the | SU DECHUN, YANG FENHE and ZHANG FUSUODepartment of Plant Nutrition, China Agricultural University, Beijing 100094 (China) | 2002 | Pedosphere2002，12，2： | 20 |
| 3 | Direct low-temperature synthesis of graphene on various glasses by plasma-enhanced chemical vapor deposition for versatile, cost-effective electrodes显示文摘在低温度的各种各样的玻璃底层上的 graphene 的没有催化剂、可伸缩的合成具有到象便宜透明电子学和最先进的显示器那样的众多的应用程序的首要的意义。然而,在这个有希望的研究领域以内的系统的学习远这样仍然保持少见。此处,我们用一个低温度的提高血浆的化学蒸汽免职方法在各种各样的眼镜上报导 graphene 的直接生长。如此的一条灵巧、可伸缩的途径在 400600 的一个生长温度范围在各种各样的玻璃底层上保证一致、没有转移的 graphene | Jingyu Sun Yubin Chen Xin Cai Bangjun Ma Zhaolong Chen Manish Kr. Priydarshi Ke Chen Teng Gao Xiuju Song Qingqing Ji Xuefeng Guo Dechun Zou Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，11： | 12 |
| 4 | ROS signaling cascades:dual regulations for osteoclast and osteoblast显示文摘Accumulating evidence indicates that intracellular reactive oxygen species(ROS)production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation.Interestingly,ROS that are known as oxidizing agents exert dose-dependent biphasic properties in bone remodeling,including preventing osteoblast activity but accelerating osteoclast resorption.ROS mainly composed of superoxide anion radical,hydroxyl radical,nitric oxide,and two-electron reduction product hydrogen peroxide,which are important components to regulate bone cell metabolism and function in mammal skeleton.These free radicals can be partly produced in bone and boosted in an inflammation state.Although numerous researches have emphasized the impacts of ROS on bone cell biology and verified the mechanism of ROS signaling cascades,the recapitulatory commentary is necessary.In this review article,we particularly focus on the regulation of the intracellular ROS and its potential mechanism impacting on cell-signaling transduction in osteoclast and osteoblast differentiation for preferable understanding the pathogenesis and searching for novel therapeutic protocols for human bone diseases. | Huaqiang Tao Gaoran Ge Xiaolong Liang Weicheng Zhang Houyi Sun Meng Li Dechun Geng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 8 |
| 5 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 6 | Asymmetric biotic interchange across the Bering land bridge between Eurasia and North America显示文摘The exchange of biotas between Eurasia and North America across the Bering land bridge had a major impact on ecosystems of both continents throughout the Cenozoic. This exchange has received particular attention regarding placental mammals dispersing into the Americas, including humans after the last glacial period, and also as an explanation for the disjunct distribution of related seed plants in eastern Asia and eastern North America. Here, we investigate bi-directional dispersal across the Bering land bridge from estimates of dispersal events based on time-calibrated phylogenies of a broad range of plant, fungus and animal taxa. We reveal a long-lasting phase of asymmetrical biotic interchange, with a peak of dispersal from Asia into North America during the late Oligocene warming(26–24 Ma), when dispersal in the opposite direction was greatly decreased. Influx from North America into Asia was lower than in the opposite direction throughout the Cenozoic, but with peak rates of dispersal at the end of the Eocene(40–34 Ma)and again in the early to middle Miocene(16–14 Ma). The strong association between dispersal patterns and environmental changes suggests that plants, fungi and animals have likely dispersed from stable to perturbed environments of North America and Eurasia throughout the Cenozoic. | Dechun Jiang Sebastian Klaus Ya-Ping Zhang David M.Hillis Jia-Tang Li | 2019 | National Science Review2019，6，4： | 5 |
| 7 | Enhanced anti-tumor immunity ex vivo induced by GM-CSF gene transducted dendritic cell vaccine显示文摘学习的目的是调查是否的目的树枝状的房间(DC ) 先锋,由 chemokine ligand 的注射招募了 3 (CCL3 ) ,在 granulocyte 巨噬细胞殖民地刺激以后导致提高的反肿瘤免疫在老鼠前 vivo 的因素(GM-CSF ) transfection。615 只老鼠经由尾巴静脉与 CCL3 被注射的方法。刚孤立的 B220-CD11c+ 房间与 cytokines 是有教养的。为 adenoviral (广告) 调停的基因 transduction, DC 是在感染(MOI ) 的复合的不同比率的转移 AdGM-CSF 基因决定最佳的基因 transfection 条件,并且在 transfection 以后检测 GM-CSF 的表示。GM-CSF 修改基因的 DC 的变化被词法观察,显型分析,和混合淋巴细胞反应(MLR ) 分析。DC 被装载,胃的癌症抗原由冻结并且融化的方法获得了。刺激 DC 种痘导致了 T 淋巴细胞,和 T 房间的杀死的效果到胃的癌症房间是由 MTT 的 assayed。INF- 生产与 INF- ELISA 工具包被决定。结果 B220-CD11c+ 房间数字在 CCL3 注射以后增加了。ELISA 结果证明在 GM-CSF 基因修正以后, DC 能生产 GM-CSF 的高水平。DC 是什么时候,在等于 1:100 的 MOI 转移了 AdGM-CSF 基因,在文化上层清液的 GM-CSF 水平到达了浸透[(130.00 ???????????????? ″ ? 匠牵楶楶? 僚 ??? 吗?? | Songbing He Liang Wang Kang Sun Yanyun Zhang Dechun Li | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 8 | A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions显示文摘Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical properties.However,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of osteoporosis.Herein,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 solution.Dominant release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone regeneration.Afterwards,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic conditions.By taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients. | Yanyan Zheng Ang Gao Jiaxiang Bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao Paul K.Chu Huaiyu Wang | 2022 | Bioactive Materials2022，7，8： | 2 |
| 9 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016，43，11： | 2 |
| 10 | The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy显示文摘Aurum nanomaterials(ANM), combining the features of nanotechnology and metal elements, have demonstrated enormous potential and aroused great attention on biomedical applications over the past few decades. Particularly, their advantages, such as controllable particle size, flexible surface modification, higher drug loading, good stability and biocompatibility, especially unique optical properties, promote the development of ANM in biomedical field. In this review, we will discuss the advanced preparation process of ANM and summarize their recent applications as well as their prospects in diagnosis and therapy. Besides, multi-functional ANM-based theranostic nanosystems will be introduced in details, including radiotherapy(RT), photothermal therapy(PTT), photodynamic therapy(PDT), immunotherapy(IT), and so on. | Dan Yang Feiyang Deng Dechun Liu Bo He Bing He Xing Tang Qiang Zhang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 2 |
| 11 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling显示文摘 | Dechun Jiang Xiangrong Bai Qingxia Zhang Wei Lu Yuqin Wang Lin Li Markus Müller | 2009 | European Journal of Clinical Pharmacology2009，，12： | 1 |
| 12 | A NOVEL PAPR REDUCTION WITH TRELLIS SHAPING FOR NC-OFDM IN COGNITIVE RADIO显示文摘In this paper, trellis shaping is applied to reducing the Peak-to-Average Power Ratio(PAPR) of NC-OFDM signals due to the fact that the total number of active subcarriers and their locations might change continuously in a dynamic spectrum access network.A new branch metric of trellis shaping is proposed which reduces the PAPR of OFDM signals through minimizing the variance of the power by VA decoder.The overall performance considerably depends on the type of signal mapping, and therefore a new type of 64QAM mapping method is designed.Simulation results show that this scheme significantly reduces the PAPR.Finally, a significant phenomenon is demonstrated that the PAPR of NC-OFDM signals in which the deactivated carriers is distributed in the Bernoulli distribution has better performance than that of OFDM signals. | Shao Fei Yu Yong Zhang Shijie Sun Dechun | 2009 | Journal of Electronics(China)2009，26，3： | 1 |
| 13 | Transcriptome dynamics of a desert poplar ( Populus pruinosa ) in response to continuous salinity stress显示文摘 | Jian Zhang Dechun Jiang Bingbing Liu Wenchun Luo Jing Lu Tao Ma Dongshi Wan | 2014 | Plant Cell Reports2014，，： | 1 |
| 14 | Prognostic Value of Speckle Tracking Echocardiography in Patients with ST ‐Elevation Myocardial Infarction Treated with Late Percutaneous Intervention显示文摘 | Tao Cong Yinghui Sun Zhijuan Shang Ke Wang Dechun Su Lei Zhong Shulong Zhang Yanzong Yang | 2015 | Echocardiography2015，，： | 1 |
| 15 | One-pot formation and characterization of macrocyclic aromatic tetrasulfonates显示文摘 | Geng Mingwei Zhang Dechun Wu Xiangxiang | 2009 | Org Lett2009，11，4： | 1 |
| 16 | Delta-shock waves as limits of vanishing viscosity for hyperbolic systems of conservation laws显示文摘 | Tan Dechun Zhang Tong Zheng Yuxi | 1994 | Journal of Differential Equations1994，112，1： | 1 |
| 17 | FPGA realization of multi port SDRAM controller in real time image acquisition system 显示文摘 | Dechun Zheng Yang Yang Ying Zhang | 2011 | Multimedia Technology2011，，： | 1 |
| 18 | Isobaric vapor-liquid equilibria for binary and ternary mixtures of propanal, propanol, and propanoic acid 显示文摘 | GAO Daming ZHU Dechun ZHANG Lingyun | 2010 | J Chem Eng Data2010，55，12： | 1 |
| 19 | One- pot formation and characterization of macrocyclic aromatic tetrasulfonates 显示文摘 | Geng Mingwei Zhang Dechun Wu Xiangxiang | 2009 | Org Lett2009，11，4： | 1 |
| 20 | Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells显示文摘 | Shuai Huang Yubo Tang Xingdong Cai Xinsheng Peng Xingmo Liu Longjuan Zhang Yucheng Xiang Dechun Wang Xi Wang Tao Pan | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
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