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| 1 | Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8^(+ ) T lymphocytes in human non-small cell lung cancer显示文摘T-cell tolerance is an important mechanism for tumor escape,but the molecular pathways involved in T-cell tolerance remain poorly understood.It remains unknown whether the inhibitory immunoreceptor programmed death-1(PD-1)plays a role in conditions of human non-small cell lung cancer(NSCLC).In this study,we detected PD-1 expression on CD81 T cells from healthy control peripheral blood mononuclear cells(PBMCs)and the PBMCs of NSCLC patients as well as NSCLC tissues.Results showed that tumor-infiltrating CD81 T cells had increased PD-1 expression and impaired immune function,including reducing cytokine production capability and impairing capacity to proliferate.Blockade of the PD-1/PD-L1 pathway by the PD-L1-specific antibody partially restored cytokine production and cell proliferation.These data provide direct evidence that the PD-1/PD-L1 pathway is involved in CD81 T-cell dysfunction in NSCLC patients.Moreover,blocking this pathway provides a potential therapy target in lung cancer. | Yan Zhang Shengdong Huang Dejun Gong Yanghua Qin Qian Shen | 2010 | Cellular & Molecular Immunology2010，7，5： | 48 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | Novel Mobility Formula for Parallel Mechanisms Expressed with Mobility of General Link Group显示文摘The determination of virtual constraints is always one of the key and difficult problems in traditional mobility calculation.To make mobility calculation simple,considering avoiding virtual constraints,some new formulae have been presented,however these formulae can hardly intuitively reflect general link group’s restrictions on output member and its influences on independence of output parameters,which is premise to the judgment of the properties of mobility.Towards the problem to reveal the intrinsic relationship between the degree of freedom(DOF)of a mechanism,the link group,and the dimension of output parameters,also to avoid determination of virtual constraint,based on the new concepts of the'DOF of general link group'and'node parameters',a new formula in the calculation of the mobility of mechanisms is presented that is expressed with DOFs of the general link groups and rank of motion parameters of base point of the output link.It is named GOM(mobility of groups and output parameter)formula.On the basis of new concepts of'effective parameters'and'invalid parameters',a rule is put forward for solving the DOF of mechanisms with invalid parameters by GOM formula,that is,the base point parameters are the subset of effective parameters of link group.Thereafter,several examples are enumerated and the results coincide with the prototype data,which proves the validity of the proposed formula.Meanwhile,it is obtained that the necessary and sufficient condition for the judgment of output parameters independence is that each of the DOF of the link group is not less than zero.The proposed formula which is simple in calculation provides theoretical basis for the judgment of independence of output parameters and provides references for type synthesis of novel parallel mechanisms with independence requirements of their output parameters. | ZHANG Yitong LU Wenjuan MU Dejun YANG Yandong ZHANG Lijie ZENG Daxing | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 14 |
| 4 | New concept and new theory of mobility calculation for multi-loop mechanisms显示文摘In 2005,Gogu,a Frenchman,analyzed 35 different existing formulas for mobility calculation and pointed that the formulas for quick mobility calculation had some limitations and were not general.Therefore,looking for a general and simple mobility formula is still a hot topic in mechanisms.At the meantime,it is also an important topic to complete the mechanism theory.Gogu proposed a new method that can avoid determining virtual constraints in 2008,but the method is still not general.To solve the problem,this paper defines the new concepts of link-group rank,general-kinematic-pair rank,virtual pair,virtual loop,and virtual-loop rank,and gives a new simple and general formula.Our method converts multi-loop mechanisms into some independent virtual loops,simplifies the problem,avoids calculating virtual constraints,and reduces the calculation difficulty.It is proved that the new formula is simple,general and effective through the mobility analysis of several different kinds of mechanisms.The application of this formula will provide great convenience for general engineers in mobility calculation. | ZHANG YiTong & MU DeJun Mechanical Engineering College of Yanshan University,Qinhuangdao 066004,China | 2010 | Science China(Technological Sciences)2010，53，6： | 12 |
| 5 | Lopingian mixed floras from Linxi Formation in Soron area,Inner Mongolia显示文摘A lot of well-preserved plants from the Linxi Formation are collected in the Soron area,Inner Mongolia,consisting of 34 species of 16 genera. They are Late Permian in age. The flora is characterized by a lot of Angaran plants,such as Paracalamites,Comia,Rhachiphyllum,Iniopteris,Rufloria,etc. Some Cathaysian elements,such as Lobatannularia lingulata,L. multifolia,Fascipteris Cathaysiantus,F. densata,Taeniopteris szei,Cladophlebis liulinensis and C. permica,are also mixed within the present flora. This indicates that the Soron of Inner Mongolia was located in the sector between the Angaran and Cathysian floristic provinces in Lopingian. It is beneficial for depicting the location and the evolution of the Solenker--Xar Moron suture zone in the phytogeographic view. The transmigration of tropical and subtropical Cathaysian plants to the north indicates that the Paleoasian Ocean was closed during the late Permian along the suture zone. | ZHANG Dejun SUN Yuewu DING Haisheng YANG Zhenyuan TANG Lijing | 2014 | Global Geology2014，17，2： | 10 |
| 6 | CRISPR/Cas9-mediated multiple gene editing in Brassica oleracea var.capitata using the endogenous tRNA-processing system显示文摘Cabbage(Brassica oleracea var.capitata)is a biennial plant with strong self-incompatibility and an obligate requirement for prolonged vernalization by exposure to low temperatures to induce flowering.These characteristics significantly increase the difficulty of exploiting novel germplasm induced by physical or chemical mutagens.In this study,we report a CRISPR/Cas9 gene-editing system based on endogenous tRNA processing to induce high efficiency and inheritable mutagenesis in cabbage.Using the phytoene desaturase gene BoPDS,the S-receptor kinase gene BoSRK,and the male-sterility-associated gene BoMS1 as the target genes,multisite and multiple gene mutations were achieved using a construct with tandemly arrayed tRNA-sgRNA architecture to express multiple sgRNAs.The BoSRK3 gene mutation suppressed self-incompatibility completely,converting the self-incompatible line into a self-compatible line.In addition,the BoMS1 gene mutation produced a completely male-sterile mutant,which was highly cross compatible with its nonmutant isoline at the flowering stage as a result of a simultaneous BoSRK3 gene mutation,enabling the economic propagation of the male-sterile line through bee-mediated cross-pollination.Interestingly,higher site mutation efficiency was detected when a guide sequence was inserted into a location in the tandemly arrayed tRNA-sgRNA architecture that was distal from the upstream Pol III promoter.In addition,mutation sites were also detected in the paralogous genes of the BoPDS and BoSRK genes that had fully consistent sequences or base mismatches but beyond the“seed”region in the spacer sequence compared with the target sgRNAs.Collectively,our results demonstrate that the CRISPR/Cas9 system,coupled with an endogenous tRNA-processing system,is an efficient tool to improve cabbage traits. | Cunfa Ma Chenzeng Zhu Min Zheng Mengci Liu Dejun Zhang Baoli Liu Qinfei Li Jun Si Xuesong Ren Hongyuan Song | 2019 | Horticulture Research2019，6，1： | 8 |
| 7 | Ferroelectricity of nanocrystalline BaTiO_3 ceramics by first principle calculation显示文摘The vibrational modes of BaTiO3 in different crystalline phases have been investigated by means of density functional theory pseudo potential method.The evidence of tetragonal to orthorhombic and orthorhombic to rhombohedral phase transitions present for 8 nm BaTiO3 ceramics further demonstrates that the similar successive transitions in 8 nm BaTiO3 ceramics from rhombohedral to orthorhombic,tetragonal and cubic transitions are as those in coarse BaTiO3 ceramics. | DENG XiangYun ZHANG HaiTao LI Ting LI DeJun LI JianBao WANG XiaoHui LI LongTu | 2010 | Chinese Science Bulletin2010，55，20： | 4 |
| 8 | The mechanism underlying overwintering death in poplar:the cumulative effect of effective freeze-thaw damage显示文摘We analyzed the relationships linking overwintering death and frost cracking to temperature and sunlight as well as the effects of low temperatures and freeze–thaw cycles on bud-burst rates,relative electrical conductivity,and phloem and cambial ultrastructures of poplar.Overwintering death rates of poplar were not correlated with negative accumulated temperature or winter minimum temperature.Freeze–thaw cycles caused more bud damage than constant exposure to low temperatures.Resistance to freeze–thaw cycles differed among clones,and the budburst rate decreased with increasing exposure to freeze–thaw cycles.Cold-resistant clones had the lowest relative electrical conductivity.Chloroplasts exhibited the fastest and the most obvious reaction to freeze–thaw damage,whereas a single freeze–thaw cycle caused little damage to cambium ultrastructure.Several such cycles resulted in damage to plasma membranes,severe damage to organelles,dehydration of cells and cell death.We conclude that overwintering death of poplar is mainly attributed to the accumulation of effective freeze–thaw damage beyond the limits of freeze–thaw resistance. | Chengchao Yang Jiandong Peng Xiaoyu Li Dejun Liang Zhiyan Yang Yan Zhang | 2020 | Journal of Forestry Research2020，31，1： | 4 |
| 9 | Coherent structures and wavepackets in subsonic transitional turbulent jets显示文摘A large eddy simulation(LES) is performed for two subsonic jets with a Reynolds number of Re = 105,which have different core temperatures, i.e., the cold and hot jet. The far-field overall sound pressure levels(OASPL)and noise spectra are well validated against previous experimental results. It is found that the OASPL is raised by heating at shallow angles. The most energetic coherent structures are extracted with specified frequencies using the filter based on the frequency domain variant of the snapshot method of proper orthogonal decomposition(POD). The m = 0, 1 modes have high coherence of near-field pressure for both jets, while the coherence of m = 0 modes is enhanced greatly by heating. Based on the coherent structures, spatial wavepackets are educed and the characteristics of growth, saturation and decay are analyzed and compared between the two jets in detail. The results show that heating would enhance the linear growth rate for high frequency components, and nonlinear growth rates for low frequency components in general, which are responsible for higher OASPL in the hot jet. The far-field sound generated by wavepackets is computed using the Kirchhoff extrapolation,which matches well with that of LES at shallow angles.This indicates that the wavepackets associated with coherent structures are dominant sound sources in forced transitional turbulent jets. Additionally, the present POD method is proven to be a robust tool to extract the salient features of the wavepackets in turbulent flows. | Haihua Yang Xingchen Zhang Lingke Ran Dejun Sun Zhenhua Wan | 2017 | Acta Mechanica Sinica2017，33，1： | 4 |
| 10 | Sound propagation from the shelfbreak to deep water显示文摘Motivated by a phenomenon in an experiment conducted in the Northwestern Pacific indicating that the energy of the received signal around the sound channel axis is much greater than that at shallower depths,we study sound propagation from the transitional area(shelfbreak)to deep water.Numerical simulations with different source depths are first performed,from which we reach the following conclusions.When the source is located near the sea surface,sound will be strongly attenuated by bottom losses in a range-independent oceanic environment,whereas it can propagate to a very long range because of the continental slope.When the source is mounted on the bottom in shallow water,acoustic energy will be trapped near the sound channel axis,and it converges more evidently than the case where the source is located near the sea surface.Then,numerical simulations with different source ranges are performed.By comparing the relative energy level in the vertical direction between the numerical simulations and the experimental data,the range of the air-gun source can be approximated. | QIN JiXing ZHANG RenHe LUO WenYu PENG ZhaoHui LIU JianJun WANG DeJun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 3 |
| 11 | Association between arterial stiffness and risk of coronary artery disease in a community-based population显示文摘 | Zhang Yun Ye Ping Luo Leiming Bai Yongyi Xu Ruyi Xiao Wenkai Liu Dejun Wu Hongmei | 2014 | Chinese Medical Journal2014，，22： | 3 |
| 12 | Assessing Drought Conditions in Cloudy Regions Using Reconstructed Land Surface Temperature显示文摘Temperature vegetation dryness index(TVDI)in a triangular or trapezoidal feature space can be calculated from the land surface temperature(LST)and normalized difference vegetation index(NDVI),and has been widely applied to regional drought monitoring.However,thermal infrared sensors cannot penetrate clouds to detect surface information of sub-cloud pixels.In cloudy areas,LST data include a large number of cloudy pixels,seriously degrading the spatial and temporal continuity of drought monitoring.In this paper,the Remotely Sensed Daily Land Surface Temperature Reconstruction model(RSDAST)is combined with the LST reconstructed(RLST)by the RSDAST and applied to drought monitoring in a cloudy area.The drought monitoring capability of the reconstructed temperature vegetation drought index(RTVDI)under cloudy conditions is evaluated by comparing the correlation between land surface observations for soil moisture and the TVDI before and after surface temperature reconstruction.Results show that the effective duration and area of the RTVDI in the study area were larger than those of the original TVDI(OTVDI)in 2011.In addition,RLST/NDVI scatter plots cover a wide range of values,with the fitted dry–wet boundaries more representative of real soil moisture conditions.Under continuously cloudy conditions,the OTVDI inverted from the original LST(OLST)loses its drought monitoring capability,whereas RTVDI can completely and accurately reconstruct surface moisture conditions across the entire study area.The correlation between TVDI and soil moisture is stronger for RTVDI(R=-0.45)than that for OTVDI(R=-0.33).In terms of the spatial and temporal distributions,the R value for correlation between RTVDI and soil moisture was higher than that for OTVDI.Hence,in continuously cloudy areas,RTVDI not only expands drought monitoring capability in time and space,but also improves the accuracy of surface soil moisture monitoring and enhances the applicability and reliability of thermal infrared data under extreme conditions. | Shiqi YANG Dejun ZHANG Liang SUN Yongqian WANG Yanghua GAO | 2020 | Journal of Meteorological Research2020，34，2： | 3 |
| 13 | Mode transition and oscillation suppression in supersonic cavity flow显示文摘Supersonic flows past two-dimensional cavities with/without control are investigated by the direct numerical simulation(DNS). For an uncontrolled cavity, as the thickness of the boundary layer declines, transition of the dominant mode from the steady mode to the Rossiter Ⅱ mode and then to the Rossiter Ⅲ mode is observed due to the change of vortex-corner interactions. Meanwhile, a low frequency mode appears. However, the wake mode observed in a subsonic cavity flow is absent in the current simulation.The oscillation frequencies obtained from a global dynamic mode decomposition(DMD)approach are consistent with the local power spectral density(PSD) analysis. The dominant mode transition is clearly shown by the dynamic modes obtained from the DMD. A passive control technique of substituting the cavity trailing edge with a quarter-circle is studied. As the effective cavity length increases, the dominant mode transition from the Rossiter Ⅱ mode to the Rossiter Ⅲ mode occurs. With the control, the pressure oscillations are reduced significantly. The interaction of the shear layer and the recirculation zone is greatly weakened, combined with weaker shear layer instability, responsible for the suppression of pressure oscillations. Moreover, active control using steady subsonic mass injection upstream of a cavity leading edge can stabilize the flow. | Chao ZHANG Zhenhua WAN Dejun SUN | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，7： | 3 |
| 14 | In vitro comparison of the hemocompatibility of diamond-like carbon and carbon nitride coatings with different atomic percentages of N显示文摘Carbon nitride (CNx) and diamond-like carbon (DLC) coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of nitrogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.12, the CN0.22 coating showed longer dynamic clotting time (about 42 min), static clotting time (23.6 min) and recalcification time (45.6 s), as well as lower platelet adhesion (102 cells μm 2), aggregation, and activation. The presence of nitrogen in the CNx coatings induced their enhanced hemocompatibility compared with DLC. | ZHAO MengLi LI DeJun ZHANG YiTeng GUO MeiXian DENG XiangYun GU HanQing WAN RongXin | 2012 | Science China(Life Sciences)2012，55，4： | 3 |
| 15 | Synthesis of nanoscale multilayered ZrN/W coatings by ion beam assisted deposition显示文摘ZrN/W multilayered coatings with different modulation periods at the nanoscale have been synthesized at different N+ beam bombarding energies using IBAD. Various characterization techniques such as XRD, AES, nano indenter and profiler were employed to investigate the influence of modulation period and bombarding energy on microstructure and mechanical properties of the coatings. The results showed that all superlattice coatings had better mechanical properties than the monolithic ZrN and W coatings. At an optimal condition with 300 eV N+ beam bombarding energy and 8―9 nm modulation period, XRD pattern possessed a sig- nificantly structural mixture of strong ZrN (111), W (110), as well as weak ZrN (220) textures in the multilayered coating. The optimal condition resulted in higher hardness (26 GPa), elastic modulus (310 GPa) and fracture resistance of the coat- ing than other conditions. | LI DeJun ZHANG JingJing WANG MingXia | 2007 | Science China(Technological Sciences)2007，50，2： | 2 |
| 16 | Green Synthesis of Magnetic Adsorbent Using Groundwater Treatment Sludge for Tetracycline Adsorption显示文摘Groundwater treatment sludge is an industrial waste that is massively produced from groundwater treatment plants.Conventional methods for treatment of this sludge,such as discharge into deep wells or the sea,or disposal at landfills,are not environmentally sustainable.Here,we demonstrate an alternative strategy to recycle the sludge by preparing a magnetic maghemite adsorbent via a one-step hydrothermal method with NaOH solution as the only solvent.With this method,the weakly magnetized sludge,which contained 33.2%iron(Fe)and other impurities(e.g.,silicon(Si),aluminum(Al),and manganese(Mn)),was converted to magnetic adsorbent(MA)with the dissolution of Si/Al oxides(e.g.,quartz and albite)into the liquid fraction.At a NaOH concentration of 2 mol L^-1,approximately 18.1%of the ferrihydrite in the Fe oxides of the sludge was converted into 11.2%maghemite and 6.9%hematite after the hydrothermal treatment.MA2(i.e.,MA produced by a 2 mol L^-1 NaOH concentration)exhibited a good magnetic response of 8.2 emu g^-1(1 emu=10^-3 A m^2),and a desirable surface site concentration of 0.75 mmol g^-1.The synthesized MA2 was used to adsorb the cationic pollutant tetracycline(TC).The adsorption kinetics of TC onto MA2 fitted well with a pseudo-second-order model,and the adsorption isotherms complied well with the Langmuir model.The maximum adsorption capacity of MA2 for TC was 362.3 mg g^-1,and the main mechanism for TC adsorption was cationic exchange.This study is the first to demonstrate the preparation of an MA from recycled sludge without a reductant and/or exogenous Fe source.The prepared adsorbent can be used as a low-cost adsorbent with high capacity for TC sorption in the treatment of TC-containing wastewater. | Zhan Qu Yaqiong Wu Suiyi Zhu Yang Yu Mingxin Huo Leilei Zhang Jiakuan Yang Dejun Bian Yi Wang | 2019 | Engineering2019，5，5： | 2 |
| 17 | VlbZIP30 of grapevine functions in dehydration tolerance via the abscisic acid core signaling pathway显示文摘Drought stress limits the growth and development of grapevines,thereby reducing productivity,but the mechanisms by which grapevines respond to drought stress remain largely uncharacterized.Here,we characterized a group A bZIP gene from“Kyoho”grapevine,VlbZIP30,which was shown to be induced by abscisic acid(ABA)and dehydration stress.Overexpression of VlbZIP30 in transgenic Arabidopsis thaliana enhanced dehydration tolerance.Transcriptome analysis revealed that a major proportion of ABA-responsive and/or drought-responsive genes are transcriptionally regulated by VlbZIP30 during ABA or mannitol treatment at the cotyledon greening stage.We identified an A.thaliana G-box motif(CACGTG)and a potential grapevine G-box motif(MCACGTGK)in the promoters of the 39 selected A.thaliana genes upregulated in the transgenic plants and in the 35 grapevine homologs,respectively.Subsequently,using two grapevine-related databases,we found that 74%(23/31)and 84%(21/25)of the detected grapevine genes were significantly upregulated by ABA and drought stress,respectively,suggesting that these genes are involved in ABA or dehydration stress and may be regulated by VlbZIP30 in grapevine.We propose that VlbZIP30 functions as a positive regulator of dehydration-responsive signaling in the ABA core signaling pathway. | Mingxing Tu Xianhang Wang Yanxun Zhu Dejun Wang Xuechuan Zhang Ye Cui Yajuan Li Min Gao Zhi Li Yuejin Wang Xiping Wang | 2018 | Horticulture Research2018，5，1： | 2 |
| 18 | Effect of the Structure of Cations and Anions of Ionic Liquids on Separation of Aromatics from Hydrocarbon Mixtures显示文摘The effects of the structure of typical cations and anions of ionic liquids on the separation of benzene and toluene from aromatic/paraffin mixtures were studied. The results showed that the corresponding separation factors were considerably larger than those of the traditional solvents (Benzene+Hexane+sulfolane), and that the ionic liquids could be used as novel solvents for the separation of aromatics from hydrocarbon mixtures. The key parameters governing the ability of ionic liquids for separating aromatics from hydrocarbon sources were investigated. It was found that the effectiveness of the ionic liquids, based on the same anion, changed in the cation order of [BIqu]+< [BPy]+< [BMIM]+. The selectivity of the ionic liquid toward aromatics decreased apparently with the increasing length of the substituted alkyl chain of its cationic head ring. The separation factors, based on the same cation, changed in the anion order of [Tf2N]-<[PF6]-<[BF4]-<[C2H5SO4]-. The solubilities of the aromatics were greater in the ionic liquids based on the former three anions than that in the ionic liquids involving [C2H5SO4]-. | Liu Yansheng Zhang Zhongxin Zhang Guofu Liu Zhichang Hu Yufeng Shi Quan Ji Dejun | 2006 | Petroleum Science2006，3，3： | 2 |
| 19 | A case of rapid growing colonic NK/T cell lymphoma complicated by Crohn's disease显示文摘A 37-year-old man developed abdominal pain and bloody diarrhea 11 months before admission. The colonoscopy revealed multifocal ulcers in the colon. Histology showed active chronic inflammation. Although anti-tuberculosis medication was effective, his symptoms repeated 2 months later. The subsequent colonoscopy revealed more extensive irregular ulcers than before, and he was clinically suspected with intestinal malignant lymphoma. He underwent subtotal colectomy and was histologically suggested Crohn's disease, then 5-aminosalicylic and a combination of prednisone and azathioprine were administered in succession postoperatively, but they achieved minimal relief of symptoms for a period of 7 months. The third colonoscopy showed a large irregular ulcer in the ileocolon stomas, and primary colonic NK/T cell lymphoma was diagnosed through histological and immunophenotypic studies. Malignant lymphoma should be taken into consideration when clinically diagnosed Crohn's disease was refractory to medication or when its clinical course became aggressive. | Shumei Zheng Hui Xu Qin Ouyang Linyun Xue Yong Zhang Dejun Cui | 2013 | Chinese Journal of Cancer Research2013，25，1： | 2 |
| 20 | An ultralow-energy negative cluster ion beam system and its application in preparation of few-layer graphene显示文摘We developed a cluster ion beam system that produces negative cluster beams of C 1-C 10 with ion current of 4.5 nA-50 A at extraction voltages ranging from 6 to 20 kV.The system uses the injector of a tandetron accelerator and was established by inserting an electrostatic scanner on its ion-optical line and modifying its Faraday cup into a substrate holder.Utilization of clusters enables ultrashallow ion implantation at energies as low as 600 eV/atom without deceleration.Small carbon clusters C 2 and C 4 were implanted into Ni/SiO 2 /Si substrates and following post-thermal treatment graphene was obtained.Raman spectroscopy showed characteristic 2D peaks with G-to-2D peak ratios revealing formation of 2-3 layers of graphene.The Raman data reveals clear effect of nonlinear cluster-surface interaction in ion beam synthesis of two-dimensional nanomaterials. | WANG ZeSong ZHANG ZaoDi ZHANG Rui WANG ShiXu FU DeJun LIU JiaRui | 2012 | Chinese Science Bulletin2012，57，27： | 2 |
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