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| 1 | Geochronology, Geochemistry and Sr-Nd-Pb-Hf Isotopes of No. I Complex from the Shitoukengde Ni–Cu Sulfide Deposit in the Eastern Kunlun Orogen, Western China: Implications for the Magmatic Source, Geodynamic Setting and Genesis显示文摘The Shitoukengde Ni-Cu deposit, located in the Eastern Kunlun Orogen, comprises three mafic–ultramafic complexes, with the No. I complex hosting six Ni-Cu orebodies found recently. The deposit is hosted in the small ultramafic bodies intruding Proterozoic metamorphic rocks. Complexes at Shitoukengde contain all kinds of mafic-ultramafic rocks, and olivine websterite and pyroxene peridotite are the most important Ni-Cu-hosted rocks. Zircon U-Pb dating suggests that the Shitoukengde Ni-Cu deposit formed in late Silurian(426–422 Ma), and their zircons have εHf(t) values of-9.4 to 5.9 with the older T_(DM1) ages(0.80–1.42 Ga). Mafic-ultramafic rocks from the No. I complex show the similar rare earth and trace element patterns, which are enriched in light rare earth elements and large ion lithophile elements(e.g., K, Rb, Th) and depleted in heavy rare earth elements and high field strength elements(e.g., Ta, Nb, Zr, Ti). Sulfides from the deposit have the slightly higher δ^(34)S values of 1.9–4.3‰ than the mantle(0 ± 2‰). The major and trace element characteristics, and Sr-Nd-Pb and Hf, S isotopes indicate that their parental magmas originated from a metasomatised, asthenospheric mantle source which had previously been modified by subduction-related fluids, and experienced significant crustal contamination both in the magma chamber and during ascent triggering S oversaturation by addition of S and Si, that resulted in the deposition and enrichment of sulfides. Combined with the tectonic evolution, we suggest that the Shitoukengde Ni-Cu deposit formed in the post-collisional, extensional regime related to the subducted oceanic slab break-off after the Wanbaogou oceanic basalt plateau collaged northward to the Qaidam Block in late Silurian. | LI Liang SUN Fengyue LI Bile LI Shijin CHEN Guangjun WANG Wei YAN Jiaming ZHAO Tuofei DONG Jun ZHANG Dexin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 10 |
| 2 | Triassic Granitic Magmatism at the Northern Margin of the North China Craton: Implications of Geochronology and Geochemistry for the Tectonic Evolution of the Central Asian Orogenic Belt显示文摘The early Mesozoic marked an important transition from collisional orogeny to post-orogenic extension at the northern margin of the North China Craton(NCC). In this study, we undertook zircon U-Pb dating and whole-rock majorand trace-element geochemical analyses of early Mesozoic granitic rocks in the Chifeng area to establish their geochronological framework, petrogenesis, and implications for the tectonic evolution of the eastern Central Asia Orogenic Belt(CAOB). Zircon U-Pb dating results show that these rocks were emplaced in three stages during the Triassic:(1) syenogranites during 250-248 Ma,(2) granodiorites during 244-243 Ma, and(3) monzogranites and granodiorites during 232-230 Ma. These Triassic granitoids belong to the high-K calc-alkaline series and are evolved I-type granites. They have high SiO2 and low Mg O contents with enrichments in light rare-earth elements, Zr, Hf, Rb, Th, and U, and depletions in Ba, Nb, Ta, Sr, and Eu. These geochemical data indicate that the granitoids were derived from partial melting of a lower-crustal source under relatively low-pressure conditions and subsequently underwent extensive fractional crystallization. Considering both the geochemical data and regional geological information, we propose that the 250-248 Ma syenogranites were emplaced in an extensional environment linked to slab break-off after closure of the Paleo-Asian Ocean(PAO) along the Solonker-Xra Moron-Changchun suture zone. The 244-243 Ma granodiorites were formed in a compressional orogenic setting during collision between the Erguna-Xing’an-Songliao composite block and the NCC. The 232-230 Ma granodiorites and monzogranites were emplaced during the transition from compressional orogeny to post-orogenic extension. Overall, the early Mesozoic tectonic evolution of the Chifeng area can be divided into three main stages:(1) closure of the Paleo-Asian Ocean and extension related to slab break-off during the Early Triassic;(2) continuous collisional compression during the Middle Triassic after closure of the PAO;and(3) post-orogenic extension during the Late Triassic, most probably due to lithospheric delamination after amalgamation of the Erguna-Xing’an-Songliao composite block and the NCC. | CHEN Jingsheng TIAN Dexin YANG Hao LI Weiwei LIU Miao LI Bin YANG Fan LI Wei WU Zhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 4 |
| 3 | Effects of temperature and light on seed germination of ephemeral plants in the Gurbantunggut Desert, China: implications for vegetation restoration显示文摘Seed germination is a key transitional stage in plant life cycle and is strongly regulated by temperature and light.Therefore, research on the effects of temperature and light on seed germination is extremely meaningful for vegetation restoration, especially in desert ecosystems.Seeds of 28 ephemeral plants collected from the Gurbantunggut Desert of China were incubated at different temperatures(5℃/1℃, 15℃/5℃, 20℃/5℃, 25℃/10℃ and 30℃/15℃) in 12-h light/12-h darkness or continuous darkness regimes, and the responses of seed germination to temperature and light and the germination speed were studied in 2016.Results showed that seed germination percentage of the 28 ephemeral plants significantly differed to temperature and light.We classified the studied plants as the following groups based on their responses to temperature: 1 low temperature responsed plants, 12 moderate temperature responsed plants, 7 high temperature responsed plants, 4 non-responsed plants and 5 plants of no germination.It should be noted that Corispermum lehmannianum Bunge is sensitive to both moderate and high temperatures.There were 4 groups of plant in response to light, i.e., 7 light responsed plants, 10 dark responsed plants, 6 light non-responsed plants and 5 plants of no germination.Based on seed germination speed of the 28 ephemeral plants, we divided them into 4 patterns of germination, i.e., very rapid, moderately rapid, moderate and slow.Combining variations of temperature, precipitation and sand dune types in the study area, we suggested that very rapid and moderately rapid germinated plants could be used to moving sand dunes in early spring during vegetation restoration, moderate germinated plants could be used to semi-fixed sand dunes in late autumn, and slow germinated plants could be used to sand plain in summer.Thus, seedling establishment and vegetation restoration would be improved by considering seed germination characteristics of these ephemeral plants in the Gurbantunggut Desert, China. | CHEN Yanfeng CAO Qiumei LI Dexin LIU Huiliang ZHANG Daoyuan | 2019 | Journal of Arid Land2019，11，6： | 4 |
| 4 | Precipitation behaviors and mechanical properties of a solution-treated Mg-Gd-Nd-Zn-Zr alloy during equal-channel angular pressing process显示文摘A magnesium alloy processed by equal-channel angular pressing (ECAP) exhibited excellent microstructure refinement and improved strength and hardness.The comprehensive mechanical properties of magnesium alloys have supported the expansion of their applications in the automotive,aerospace,and biomedical industries.Herein,pre-treatment of a solution-treated Mg-2.9Gd-1.5Nd-0.3Zn-0.3Zr alloy was conducted to investigate the precipitate behavior and microstructure evolution during the ECAP process.β;phase grains quickly precipitated from the solution-treated alloy,which accelerated grain refinement and enhanced the ductility after the ECAP process,as compared to the as-cast alloy reported in our previous study.Moreover,spherical precipitates (~200 nm) and fine phases (~100 nm) precipitated along the stripe-like Zn;Zr;phase,which formed a kabap-like structure dispersing homogeneously in the solution-treated alloy during the ECAP process.Owing to grain refinement,dislocations,sphericalβ;precipitates,and texture evolution,the solution-treated alloy after eight passes of ECAP exhibited good comprehensive mechanical properties,with the ultimate tensile strength,yield strength,and elongation values reaching210.9 MPa,263.9 MPa,and 27.9%,respectively. | Zhenzhen Gui Fen Wang Junyi Zhang Dexin Chen Zhixin Kang | 2022 | Journal of Magnesium and Alloys2022，10，1： | 3 |
| 5 | Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has precipitated multiple variants resistant to therapeutic antibodies.In this study,12 high-affinity antibodies were generated from convalescent donors in early outbreaks using immune antibody phage display libraries.Of them,two RBD-binding antibodies(F61 and H121)showed high-affinity neutralization against SARS-Co V-2,whereas three S2-target antibodies failed to neutralize SARS-Co V-2.Following structure analysis,F61 identified a linear epitope located in residues G446–S494,which overlapped with angiotensinconverting enzyme 2(ACE2)binding sites,while H121 recognized a conformational epitope located on the side face of RBD,outside from ACE2 binding domain.Hence the cocktail of the two antibodies achieved better performance of neutralization to SARS-Co V-2.Importantly,these two antibodies also showed efficient neutralizing activities to the variants including B.1.1.7 and B.1.351,and reacted with mutations of N501 Y,E484 K,and L452 R,indicated that it may also neutralize the recent India endemic strain B.1.617.The unchanged binding activity of F61 and H121 to RBD with multiple mutations revealed a broad neutralizing activity against variants,which mitigated the risk of viral escape.Our findings revealed the therapeutic basis of cocktail antibodies against constantly emerging SARS-Co V-2 variants and provided promising candidate antibodies to clinical treatment of COVID-19 patients infected with broad SARS-Co V-2 variants. | Yuanyuan Qu Xueyan Zhang Meiyu Wang Lina Sun Yongzhong Jiang Cheng Li Wei Wu Zhen Chen Qiangling Yin Xiaolin Jiang Yang Liu Chuan Li Jiandong Li Tianlei Ying Dexin Li Faxian Zhan Youchun Wang Wuxiang Guan Shiwen Wang Mifang Liang | 2021 | Virologica Sinica2021，36，5： | 3 |
| 6 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 7 | Optimized prime editing efficiently generates glyphosate-resistant rice plants carrying homozygous TAP-IVS mutation in EPSPS显示文摘Dear Editor,Prime editing is a novel and universal CRISPR-Cas-derived precise genome-editing technology and has great potentials for applications in basic plant research and crop molecular breeding(Anzalone et al.,2019).Although low efficiency has restrained the original prime editors(PEs)from being used as a routine tool for precise genome editing in plants,an iterative update of the PEs is removing this obstacle(Lin et al.,2021;Xu et al.,2022).Recently,the Liu group reported three optimization strategies for improving prime editing efficiency(Chen et al.,2021;Nelson et al.,2022).The first strategy is based on engineered prime editing guide RNAs(epegRNAs),which were generated by incorporating structured RNA motifs to the 3′terminus of pegRNAs.This strategy enhances pegRNA stability and prevents degradation of the 3′extension(Nelson et al.,2022).The second strategy is based on the optimized PE2 protein(PEmax),which harbors a SpCas9 variant with increased nuclease activity,an additional nuclear localization signal(NLS)sequences,and a new linker between nCas9 and reverse transcriptase(Chen et al.,2021).The third strategy is based on inhibition of DNA mismatch repair(MMR)in cells(Chen et al.,2021).In this work,we tested the optimized PEs generated with these three strategies in rice,demonstrating that the optimized PEs greatly improved prime editing efficiency in rice.We named the two optimized PEs ePE3max and ePE5max:the former is comprised of the PEmax protein,an epegRNA with evopreQ1 appended to its 3′end,and a nicking sgRNA;the latter is comprised of the ePE3max system and a dominant negative OsMLH1 variant for inhibiting MMR.Using the two optimized PEs,we efficiently generated homozygous and heterozygous T173I,A174V,and P177S(TAP-IVS)mutation in EPSPS in rice,which lays a solid foundation for rice non-transgenic glyphosate-resistance breeding. | Yuanyuan Jiang Yiping Chai Dexin Qiao Junya Wang Cuiping Xin Wei Sun Zhenghong Cao Yu Zhang Yun Zhou Xue-Chen Wang Qi-Jun Chen | 2022 | Molecular Plant2022，15，11： | 3 |
| 8 | Analysis and active control of low frequency booming noise in car显示文摘For Lightweight body,sound radiation and sound insulation performance have negative effects on interior noise by the deterioration of local stiffness and modality.So the research on the active control of vibration and noise for car body panels is useful for engineering.Analysis and active control of booming noise in car is researched by using a new active damping vibration reduction technology named smart constrained layer damping(SCLD).According to the vibration characters of body roof,an optimal placement of actuators is distributed.Based on dSPACE hardware in loop environment,an adaptive active control system is designed.Selecting vibration signals of engine mounting point as the reference input of adaptive controller,an active control experiment of booming noise for mini-car is carried out.Experimental results show that,when the engine speed is at 3700 RPM and4250RPM,the interior booming noise decreases 4.2dB(A),and 3.5dB(A) separately.It proposes new methods and techniques for intelligent control of car body NVH in the future. | 曹友强 Deng Zhaoxiang Zhang Yu Chen Dexin | 2015 | High Technology Letters2015，21，4： | 2 |
| 9 | Fluorouracil-based preoperative chemoradiotherapy with or without oxaliplatin for stage Ⅱ/Ⅲ rectal cancer:a 3-year follow-up study显示文摘Background:Fluorouracil-based preoperative chemoradiotherapy has become the standard treatment for stage II/III rectal cancer.In order to improve the overall survival(OS) and disease-free survival(DFS),we added oxaliplatin to the standard treatment,and compared the effectiveness of these two treatment patterns.Methods:A total of 206 patients enrolled in the prospective study had histologically confirmed rectal cancer of clinical stage II/III during July 2007 to July 2010.They were randomized into the experimental group received oxaliplatin and capecitabine in combination with radiotherapy,and the control group received capecitabine in combination with radiotherapy.All patients received surgery in 6-10 weeks after chemoradiotherapy and adjuvant chemotherapy with m FOLFOX6.The primary endpoints were DFS and OS,and the secondary endpoints included toxicity,compliance,and histopathological response.Results:The 3-year OS in the experimental group and the control group was 90.29% vs.86.41%(P>0.05),and the 3-year DFS was 80.58% vs.69.90%(P>0.05).The pathological complete remission(p CR) rates were 23.30% and 19.42%,respectively(P=0.497).The 3-year local recurrence rates were 4.85% vs.5.83%(P=0.694),and the 3-year distant metastasis rates were 16.50% and 28.16%,respectively(P=0.045).There were no significant differences in most grade 3-4 toxicities between two groups,however,grade 3-4 diarrhea occurred in 16.50%(17/103) of the experimental group,compared with 6.80%(7/103) of the control group(P=0.030).Also,the total grade 3-4 acute toxicity showed a significant difference(10.68% vs.21.36%,P=0.037).Conclusions:The experimental treatment did not lead significantly improved OS and DFS,and thus longer follow-up is warranted for our patient cohort.Adding oxaliplatin to capecitabine-based preoperative chemoradiotherapy can significantly reduce metastasis,but has only minimal impact on local recurrence.Although grade 3-4 toxicity rate increased(primarily gastrointestinal toxicity),patients can stand to be followed up with allopathic treatment. | Dexin Jiao Rui Zhang Zhiqiang Gong Fang Liu Yue Chen Qinrui Yu Liping Sun Hongyan Duan Shendong Zhu Fei Liu Jian Wang Jianhui Jia | 2015 | Chinese Journal of Cancer Research2015，27，6： | 2 |
| 10 | Optimized prime editing efficiently generates heritable mutations in maize显示文摘Low efficiency is the main obstacle to using prime editing in maize(Zea mays).Recently,prime-editing efficiency was greatly improved in mammalian cells and rice(Oryza sativa)plants by engineering primeediting guide RNAs(pegRNAs),optimizing the prime editor(PE)protein,and manipulating cellular determinants of prime editing.In this study,we tested PEs optimized via these three strategies in maize.We demonstrated that the ePE5max system,composed of PEmax,epegRNAs(pegRNA-evopreQ.1),nicking single guide RNAs(sgRNAs),and MLH1dn,efficiently generated heritable mutations that conferred resistance to herbicides that inhibit 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS),acetolactate synthase(ALS),or acetyl CoA carboxylase(ACCase)activity.Collectively,we demonstrate that the ePE5max system has sufficient efficiency to generate heritable(homozygous or heterozygous)mutations in maize target genes and that the main obstacle to using PEs in maize has thus been removed. | Dexin Qiao Junya Wang Min‐Hui Lu Cuiping Xin Yiping Chai Yuanyuan Jiang Wei Sun Zhenghong Cao Siyi Guo Xue‐Chen Wang Qi‐Jun Chen | 2023 | Journal of Integrative Plant Biology2023，65，4： | 1 |
| 11 | Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent显示文摘 | Zhijin Chen Dexin Yu Shaojie Wang Na Zhang Chunhong Ma Zaijun Lu | 2009 | Nanoscale Research Letters2009，，7： | 1 |
| 12 | Geochemical evidence for mudstone as the possible major oil source rock in the Jurassic Turpan Basin, Northwest China显示文摘 | Chen Jianping Qin Yong Huff B G Wang Darui Hart Dexin Huang Difan | 2001 | OrgGeochem2001，32，9： | 1 |
| 13 | Finite element analysis of gradient z -coil induced eddy currents in a permanent MRI magnet显示文摘 | Xia Li Ling Xia Wufan Chen Feng Liu Stuart Crozier Dexin Xie | 2010 | Journal of Magnetic Resonance2010，，1： | 1 |
| 14 | Generation and characterization of neutralizing human recombinant antibodies against antigenic site II of rabies virus glycoprotein显示文摘 | Lina Sun Zhe Chen Li Yu Jingshuang Wei Chuan Li Jing Jin Xinxin Shen Xinjun Lv Qing Tang Dexin Li Mifang Liang | 2012 | Applied Microbiology and Biotechnology2012，，2： | 1 |
| 15 | Optimization design of grading ring and electrical field analysis of 800 kV UHVDC wall bushing显示文摘 | Nie Dexin Zhang Hailong Chen Zhong | 2013 | IEEE Transactions on Dielectrics and Electrical Insulation2013，20，4： | 1 |
| 16 | Geochemical evidence for mudstone as the possible major oil source rock in the Jurassic Turpan Basin, Northwest China显示文摘 | Chen Jianping Qin Yong Huffe B G Wang Darui Han Dexin Huang Difan | 2001 | Org Geochem2001，32，9： | 1 |
| 17 | The synthesis of actals and ketalswith heteropoly-acids显示文摘 | ZHANG Jinfen CHEN Tong ZHANG Dexin | 1995 | Flavour Fragrance Cosmetics1995，，4： | 1 |
| 18 | Optimiza- tion design of grading ring and electrical field analysis of 800 kV UHVDC wall bushing显示文摘 | NIE Dexin ZHANG Hailong CHEN Zhong | 2013 | IEEE Transactionon Di- electrics and Electrical Insulation2013，20，4： | 1 |
| 19 | Interval method for global solutions of a class of min-max-min problems 显示文摘 | CAO Dexin CHEN Meirong WANG Haijun | 2008 | Applied Mathematics and Computation2008，196，2： | 1 |
| 20 | Biocontrol of rice blast by the phena-rninomethylacetic acid producer of Bacillus methylotrophicus strain BC79显示文摘 | SHAN Hongying ZHAO Mingmin CHEN Dexin | 2013 | Crop Protection2013，44，： | 1 |
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