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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | High laccase producing mutants of Pleurotus florida显示文摘 | Dhaliwal R P S Garcha H S Khanna P K | 1992 | World Journal of Microbiology and Biotechnology1992，8，： | 1 |
| 3 | Scavenger rece- ptors and oxidized low density lipoproteins 显示文摘 | DHALIWAL B S STEINBRECHER U P | 1999 | Clin Chim Acta1999，286，12： | 1 |
| 4 | Dose and dura- tion of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve in- jury in the rat显示文摘 | Kemp S W P Webb A A Dhaliwal S etal | 2011 | Experimental Neurology2011，229，2： | 1 |
| 5 | Post-SOX Management Influence on Auditor Selectionand Subsequent Impairments of Auditor Independence显示文摘 | Dhaliwal D S Lamoreaux P Lennox C | 2012 | Available at SSRN 20187022012，，： | 1 |
| 6 | The progression of neph- rogenic metaplasia of the urinary bladder to clear cell adenocarcinoma: a case report显示文摘 | Dhaliwal C A Fineron P W | 2012 | Curr Urol2012，6，2： | 1 |
| 7 | High laccase producing mutants of Pleurotus florida显示文摘 | Dhaliwal R P S Garcha H S Khanna P K | 1992 | World Journal of Microbiology and Biotechnology1992，，8： | 1 |
| 8 | Ploidy analysis of haploid derived tissue cultures of Zea mays by chromocentre eounting显示文摘 | DHALIWAL H S KING P J | 1979 | Maydica1979，24，： | 1 |
| 9 | Scavenger receptors and oxidized low density lipoproteins 显示文摘 | Dhaliwal B S Steinbrecher U P | 1999 | Clin Chim Acta1999，286，12： | 1 |
| 10 | Clinical evaluation of changes in cornea and tear film after surgery for trachomatous upper lid entropion显示文摘 | Monga P Gupta VP Dhaliwal U | | 0，，： | 1 |
| 11 | Enzymatic activities and rheological properties of stored rice显示文摘 | Dhaliwal Y S Sekhon K S Nagi H P S | 1991 | Cereal Chemistry1991，，1： | 1 |
| 12 | Retinopathy of prematurity-risk factors显示文摘 | GUPTA V P DHALIWAL U SHARMA R | 2004 | India J pediatr2004，71，10： | 1 |
| 13 | Biochemical selection of immature, haploid embryos of Zea mays L显示文摘 | Dhaliwal H S King P J | 1979 | Theoretical and Applied Genetics1979，55，6： | 1 |
| 14 | Scavenger receptors and oxidized low density lipoproteins显示文摘 | Dhaliwal B S Steinbrecher U P | 1999 | Clin Chim Acta1999，286，12： | 1 |
| 15 | Steady - state pharmaeo-kinetics of hydromorphone and hydromorphone - 3 - gl ucuronide incancer patients atier immediate and controlled - release hydromor-phone显示文摘 | Hagen N Thirlwell M P Dhaliwal H | 1995 | J Clin Pharmacol1995，35，1： | 1 |
| 16 | Aegilops kotschyi and Aegilops tauschii as sources for higher levels of grain iron and zinc显示文摘 | Chhuneja P Dhaliwal H S Bains N S | 2006 | Plant Breed2006，125，： | 1 |
| 17 | High laccase producing mutants of pleurotus florida显示文摘 | R P S Dhaliwal H S Garandcha Khanna P K | 1992 | Worle journal of Microfiology and Biotechnology1992，，8： | 1 |
| 18 | Incidence and risk factorsfor the development of prolonged and severe intrahepatic cholestasis after liver transplantation 显示文摘 | Fusai G Dhaliwal P Roland N | 2006 | Liver Transpl2006，12，11： | 1 |
| 19 | Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequesterd in lysosomes and fails to efflux normally显示文摘 | Dhaliwal B S Steinbecher U P | 2000 | J Lipid Res2000，14，10： | 1 |
| 20 | Major Customer Reliance and Auditor Going-concern Decisions 显示文摘 | Dhaliwal D Michas P N Naiker V | 2013 | Working Paper2013，，： | 1 |
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