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| 1 | Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases显示文摘Anti-tumor necrosis factor(TNF) antibodies are successfully used in the therapy of inflammatory bowel diseases(IBD). However, the molecular mechanism of action of these agents is still a matter of debate. Apart from neutralization of TNF, influence on the intestinal barrier function, induction of apoptosis in mucosal immune cells, formation of regulatory macrophages as well as other immune modulating properties have been discussed as central features. Nevertheless, clinically effective anti-TNF antibodies were shown to differ in their mode-of-action in vivo and in vitro. Furthermore, the anti-TNF agent etanercept is effective in the treatment of rheumatoid arthritis but failed to induce clinical response in Crohn's disease patients, suggesting different contributions of TNF in the pathogenesis of these inflammatory diseases. In the following, we will review different aspects regarding the mechanism of action of anti-TNF agents in general and analyze comparatively different effects of each antiTNF agent such as TNF neutralization, modulation of the immune system, reverse signaling and induction of apoptosis. We discuss the relevance of the membranebound form of TNF compared to the soluble form for the immunopathogenesis of IBD. Furthermore, we review reports that could lead to personalized medicine approaches regarding treatment with antiTNF antibodies in chronic intestinal inflammation, by predicting response to therapy. | Ulrike Billmeier Walburga Dieterich Markus F Neurath Raja Atreya | 2016 | World Journal of Gastroenterology2016，22，42： | 19 |
| 2 | 知识分子危机与批判精神的复苏(一)显示文摘 | 索飒 海因兹.迪特里齐(Heinz Dieterich) | 2002 | 读书2002，，5： | 15 |
| 3 | Pro?ling and Validation of the Circular RNA Repertoire in Adult Murine Hearts显示文摘For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes(e.g., cardiomyopathy) and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs(circ RNAs) are an emerging player. circ RNAs, which originate through back-splicing events from primary transcripts, are resistant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circ RNAs. We provide, for the ?rst time, a comprehensive catalogue of RNase R-resistant circ RNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circ RNA landscape of heart tissue.Overall, we identi?ed 575 circ RNA species that pass a beta-binomial test for enrichment(false discovery rate of 1%) in the exonuclease-treated sequencing sample. Several circ RNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circ RNAs may reveal disease-relevant properties or functions of speci?c circ RNAs. | Tobias Jakobi Lisa F. Czaja-Hasse Richard Reinhardt Christoph Dieterich | 2016 | Genomics, Proteomics & Bioinformatics2016，14，4： | 13 |
| 4 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2008 Update显示文摘 | Emmet B. Keeffe Douglas T. Dieterich Steven-Huy B. Han Ira M. Jacobson Paul Martin Eugene R. Schiff Hillel Tobias | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 5 |
| 5 | Treating hepatitis C: current standard of care and emerging direct‐acting antiviral agents显示文摘 | F. Poordad D. Dieterich | 2012 | Journal of Viral Hepatitis2012，，7： | 4 |
| 6 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 7 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update显示文摘 | Emmet B. Keeffe Douglas T. Dieterich Steven–Huy B. Han Ira M. Jacobson Paul Martin Eugene R. Schiff Hillel Tobias Teresa L. Wright | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 8 | Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction显示文摘 | Ingo Eitel Volker Adams Patrick Dieterich Georg Fuernau Suzanne de Waha Steffen Desch Gerhard Schuler Holger Thiele | 2012 | American Heart Journal2012，，： | 2 |
| 9 | Chronic hepatitis B:preventing,detecting,and managing viral resistance显示文摘 | Keeffe EB Dieterich DT Pawlotsky JM | | 0，，： | 2 |
| 10 | 针刺加耳尖放血治疗高血压显示文摘 | Dieterich | 2000 | 上海针灸杂志2000，19，2： | 2 |
| 11 | Use of hydroxyethyl starch in patients with renal insufficiency显示文摘 | Dieterich HJ | 1996 | Anaesthsist1996，45，10： | 1 |
| 12 | Dominance for vestibular cortical function in the non-dominant hemisphere显示文摘 | Dieterich M Bense S Lutz S | 2003 | Cerebral Cortex2003，13，9： | 1 |
| 13 | VIIIth nerve vascular compression syn- drome : vestibular paroxysmia 显示文摘 | Brandt T Dieterich M | 1994 | Baillieres Clin Neurol1994，3，3： | 1 |
| 14 | Diffusion in polymer electrolytes and the dynamic percolation model显示文摘 | Durr O Dieterich W Nitzan A | 2002 | Solid State Ionics2002，149，： | 1 |
| 15 | Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia显示文摘 | Dieterich HJ Weissmuller T Rosenberger P | 2006 | Crit Care Med2006，34，6： | 1 |
| 16 | A treatment algorithm for the man- agement of chronic hepatitis B virus infection in the United States: an update 显示文摘 | Keeffe EB Dieterich DT Han SH | 2006 | Clin Gastroenterol Hepatul2006，4，8： | 1 |
| 17 | A robotic 3-D motion sjmulator forenhanced accuracy in cyberl nife stereotactic radiosurgery显示文摘 | Zhou T Tang J Dieterich s | 2004 | Int congrser2004，1268，： | 1 |
| 18 | The results of arthroscopic lavage and debridement of osteoarthritic knees on the se- verity of degeneration : a 4 to 6 - year symptomatic follow - up 显示文摘 | Jackson RW Dieterichs C | 2003 | Arthroscopy2003，19，1： | 1 |
| 19 | Vestibular paroxysmia : vascular compression of the eighth nerve 显示文摘 | Brandt T Dieterich M | 1994 | Lancet1994，343，8900： | 1 |
| 20 | Variable compre- ssion ratio for gasoline engines显示文摘 | Weinowski R Wittek K Dieterich C | 2012 | MTZ Worldwide2012，2012，： | 1 |
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