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16篇 您的检索式：作者名="Dillon P O"

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		题名	作者	年代	出处	被引量
	1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
	2	显示文摘	Mo Y G Dillon R O Snyder P G	1999	Thin Solid Films1999，355，：	1
	3	Optical properties of photochromic organic-inorganic composites显示文摘	MO Y G DILLON R O SNYDER P G	1999	Thin Solid Films1999，3553，：	1
	4	TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventrieular cerebrospinal fluid 显示文摘	Vawter MP Dillon Carter O Carvey P	1996	Exp Neurol1996，142，：	1
	5	Progres- sive Tool-Wear in Machining with Coated Grooved Tools and Its Correlation with Cutting Temperature显示文摘	Wanigarathne P C Kardekar A D Dillon O W	2005	Wear2005，259，712：	1
	6	Progression tool-wear in machining with coated grooved tools and its correlation with cutting tempera- ture显示文摘	Wanigarathne P C Kardekar A D Dillon O W	2005	Wear2005，259，712：	1
	7	Origin of disturbances in cocurrent gas-liquid packed-bed flows显示文摘	Krieg D A Helwick J A Dillon P O McCready M J	1995	AIChE Journal1995，41，：	1
	8	Production, purification and characterisation of genetically derived scFv and bifunctional antibody fragments capable of detecting illicit drug residues 显示文摘	Brennan J Dillon P O'Kennedy R	2003	Journal of Chromatography B2003，786，：	1
	9	Effect of genetic merit,milk yield,body condition and lactation number on in vitro oocyte development in dairy cows 显示文摘	Dillon P O Callaghan D O Boland M P	2000	Theriogenology2000，53，：	1
	10	Visible and infrared photochromic properties of amorphous WO3-x films显示文摘	Mo Y G Dillon R O Snyder P G	1999	J Vacuum Sci Techn A1999，17，5：	1
	11	Use of phosphonic acid as a generic hapten in the production of broad specificity anti- organophosphate pesticide antibody 显示文摘	Alcocer M J C Dillon P P Maming B M Doyen C Lee H A Daly S J O' Kennedy R Morgan M R A	2000	Journal of Agriculture and Food Chemistry2000，48，6：	1
	12	Compact core drilling in basalt rock using PCD tool inserts : wear characteris- tics and cutting forces 显示文摘	Hamade R F Manthri S P Pusavec F Zacny K A Taylor L A Dillon Jr O W	2010	Journal of Materials Pro- cessing Technology2010，210，10：	1
	13	Ecological patterns in the Bmmeliaceae of the lomas formations of coastal Chile and Peru 显示文摘	RUNDEL P W DILLON M O	1998	Plant Systematics and Evolution1998，212，：	1
	14	Is the extent of glaciation limited by marine gas-hydrates显示文摘	Paull C K Ussler W O'Dillon W P	1991	Geophysical Research Letters1991，18，：	1
	15	显示文摘	Dillon R O Snyder P G	1999	Journal of Vacuum Science and Technology1999，17，5：	1
	16	Production,purification and characterisation of genetically derived scFv and bifunctional antibody fragments capable of detecting illicit drug residues显示文摘	Brennan J Dillon P O'Kennedy R	2003	J Chromatogr B Analyt Technol Biomed Life Sci2003，786，12：	1

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