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| 1 | PHYSICAL MODELING FOR THE MECHANISMS OF BEAD FORMATION DEFECTS BASED ON THE STABILITY OF LIQUID METAL显示文摘Based on the theory of stability of the liquid metal under the action of surface tension,a physical mod- el is established for the mechanisms of the bead formation deferct’ humping’, which is generated during high - speed welding.A boundary function is introduced to correct the model,theoretical results got by the model correspond well with the experimental phenomena. A two - dimensional conducting model is adoopted in the simulation of the temperature field during high - speed welding.Finally, the factors acting upon the stability of liquid metal are analyzed. | S. Y. Yin L. Feng J. Z. Ding and S. J. Chan( 1) Beijing Polytechnic University, Beijing 100022, China 2) National Key Laboratory of Advanced Wdlding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 28 |
| 2 | Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis显示文摘Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganoderma lucidum (GL) has emerged as a novel age nt that protects neurons from oxidative stress. However, the detailed mechanisms underlying GL-induced neuroprotection have not been documented. In this study, we investigated the neuroprotective effects of GL extract (GLE) and the underlying mechanisms in the classic MPTP(1 -methyl-4-phenyl-1,2,3,6- tetrahydropyridine)-induced mouse model of PD. Mice were injected with MPTP to in duce parkins on ism. The n the mice were administered GLE (400 mg kg^-1 d^-1,ig) for 4 weeks. We observed that GLE administration significantly improved locomotor performanee and increased tyrosine hydroxylase expression in the substantia nigra pars compact (SNpc) of MPTP-treated mice. In in vitro study, treatment of neuroblastoma neuro-2a cells with 1 -methyl-4-phenyIpyridinium (MPP^+, 1 mmol/L) caused mitochondrial membrane potential collapse, radical oxygen species accumulation, and ATP depletion. Application of GLE (800 pg/mL) protected n euroblastoma neu ro-2a cells agai nst MPP in suit. Application of GLE also improved mitochondrial movement dysfunction in cultured primary mesencephalic neurons. In addition, GLE counteracted the decline in NIX (also called BNIP3L) expression and increase in the LC3-II/LC3-I ratio evoked by MPP I Moreover, GLE reactivated MPP^+-inhibited AMPK, mTOR, and ULK1. Similarly, GLE was sufficient to counteract MPP1 -induced inhibition of PINK1 and Parkin expression. GLE suppressed MPP^+-induced cytochrome C release and activation of caspase-3 and caspase-9. In summary, our results provide evidence that GLE ameliorates parkinsonism pathology via regulating mitochondrial function, autophagy, and apoptosis, which may involve the activation of both the AMPK/mTOR and PINK1/Parkin signaling pathway. | Zhi-li Ren Chao-dong Wang Tao Wang Hui Ding Ming Zhou Nan Yang Yan-yong Liu Piu Chan | 2019 | Acta Pharmacologica Sinica2019，40，4： | 10 |
| 3 | Enabling Industrial Internet of Things(IIoT) towards an emerging smart energy system显示文摘The increasing penetration of renewable energy on the transmission and distribution power network is driving the adoption of two-way power flow control, data and communications needed to meet the dependency of balancing generation and load. Thus, creating an environment where power and information flow seamlessly in real time to enable reliable and economically viable energy delivery, the advent of Internet of Energy(IoE) as well as the rising of Internet of Things(IoT) based smart systems.The evolution of IT to Io T has shown that an information network can be connected in an autonomous way via routers from operating system(OS) based computers and devices to build a highly intelligent eco-system. Conceptually, we are applying the same methodology to the Io E concept so that Energy Operating System(EOS) based assets and devices can be developed into a distributed energy network via energy gateway and self-organized into a smart energy eco-system.This paper introduces a laboratory based IIo T driven software and controls platform developed on the NICE Nano-grid as part of a NICE smart system Initiative for Shenhua group. The goal of this effort is to develop an open architecture based Industrial Smart Energy Consortium(ISEC) to attract industrial partners, academic universities, module supplies, equipment vendors and related stakeholder to explore and contribute into a test-bed centric open laboratory template and platform for next generation energy-oriented smart industry applications.In the meanwhile, ISEC will play an important role to drive interoperability standards for the mining industry so that the era of un-manned underground mining operation can become the reality as well as increasing safety regulation enforcement. | Ding Zhang Ching Chuen Chan George You Zhou | 2018 | Global Energy Interconnection2018，1，1： | 9 |
| 4 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 5 | Integrating landscape ecological principles and land evaluation for sustainable land use显示文摘1IntroductionRisingpopulationscompetingforlimitedlandresourceshavefocusedatentionontheneedforincreasingfoodproduction,whilepr... | Fu Bo jie, Chen Li ding Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China He Chan sheng Department of Geography, Western Michigan University, Kalamazoo, MI 49008, USA | 1999 | Journal of Environmental Sciences1999，11，2： | 8 |
| 6 | Overexpression of the Suaeda salsa SsNHX1 gene confers enhanced salt and drought tolerance to transgenic Zea mays显示文摘Maize is one of the most important crops worldwide, but it suffers from salt stress when grown in saline-alkaline soil. There is therefore an urgent need to improve maize salt tolerance and crop yield. In this study, the SsNHX1 gene of Suaeda salsa, which encodes a vacuolar membrane Na^+/H^+ antiporter, was transformed into the maize inbred line 18-599 by Agrobacterium-mediated transformation. Transgenic maize plants overexpressing the SsNHX1 gene showed less growth retardation when treated with an increasing NaCl gradient of up to 1%, indicating enhanced salt tolerance. The improved salt tolerance of transgenic plants was also demonstrated by a significantly elevated seed germination rate(79%) and a reduction in seminal root length inhibition. Moreover, transgenic plants under salt stress exhibited less physiological damage. SsNHX1-overexpressing transgenic maize accumulated more Na^+ and K^+ than wild-type(WT) plants particularly in the leaves, resulting in a higher ratio of K^+/Na^+ in the leaves under salt stress. This result revealed that the improved salt tolerance of SsNHX1-overexpressing transgenic maize plants was likely attributed to SsNHX1-mediated localization of Na^+ to vacuoles and subsequent maintenance of the cytosolic ionic balance. In addition, SsNHX1 overexpression also improved the drought tolerance of the transgenic maize plants, as rehydrated transgenic plants were restored to normal growth while WT plants did not grow normally after dehydration treatment. Therefore, based on our engineering approach, SsNHX1 represents a promising candidate gene for improving the salt and drought tolerance of maize and other crops. | HUANG Ying ZHANG Xiao-xia LI Yi-hong DING Jian-zhou DU Han-mei ZHAO Zhuo ZHOU Li-na LIU Chan GAO Shi-bin CAO Mo-ju LU Yan-li ZHANG Su-zhi | 2018 | Journal of Integrative Agriculture2018，17，12： | 8 |
| 7 | Low-Level Wind Shear Characteristics and Lidar-Based Alerting at Lanzhou Zhongchuan International Airport,China显示文摘Lanzhou Zhongchuan International Airport[International Civil Aviation Organization(ICAO)code ZLLL]is located in a wind shear prone area in China,where most low-level wind shear events occur in dry weather conditions.We analyzed temporal distribution and synoptic circulation background for 18 dry wind shear events reported by pilots at ZLLL by using the NCEP final(FNL)operational global analysis data,and then proposed a lidar-based regional divergence algorithm(RDA)to determine wind shear intensity and location.Low-level wind shear at ZLLL usually occurs in the afternoon and evening in dry conditions.Most wind shear events occur in an unstable atmosphere over ZLLL,with changes in wind speed or direction generally found at 700 hPa and 10-m height.Based on synoptic circulations at 700 hPa,wind shear events could be classified as strong northerly,convergence,southerly,and weak wind types.The proposed RDA successfully identified low-level wind shear except one southerly case,achieving94%alerting rate compared with 82%for the operational system at ZLLL and 88%for the ramp detection algorithm(widely used in some operational alert systems)based on the same dataset.The RDA-unidentified southerly case occurred in a near neutral atmosphere,and wind speed change could not be captured by the Doppler lidar. | Lanqian LI Aimei SHAO Kaijun ZHANG Nan DING Pak-Wai CHAN | 2020 | Journal of Meteorological Research2020，34，3： | 6 |
| 8 | CHOP调控内质网应激介导细胞凋亡的机制显示文摘C/EBP同源蛋白CHOP是一种29K的细胞蛋白,主要参与调控细胞增殖、分化以及能量代谢等。CHOP作为转录因子在内质网应激(ER Stress,ERS)介导的细胞凋亡中起重要作用。ERS通常是指ER中错误折叠或未折叠蛋白质增加引起的应激反应。发生ERS时,细胞会通过未折叠蛋白反应(UPR)维持细胞内稳态。长期或过度的应激会导致ER功能障碍和凋亡发生。ER通过3个主要途径诱导细胞凋亡,包括IRE1/ASK1/JNK途径、Caspase-12 激酶途径和CHOP途径。 | Hu Hai Tian Ming-xing Ding Chan | 2019 | 中国预防兽医学报2019，41，2： | 4 |
| 9 | Marek's disease virus VP22 enhances potentially the immune response of E SAT-6/CFP-10 against Mycobacterium bovis infection显示文摘对 Mycobacterium bovis 的当前可得到的疫苗,肺结核的原因的代理人,别提供可靠功效,因此对有改进功效的一支新奇疫苗有需要。这里,我们使用蛋白质 transduction 技术交付直接表示 mycobacterial 抗原指向房间的 DNA 疫苗。我们使用了包括 VP22 的领域(PTD ) 蛋白质从 Marek 的疾病病毒 serotype 结合的各种各样的蛋白质 transduction 1 (MDV-1 ) ,作为为编码抗原的 DNA 构造的交货系统,早能分泌的 antigenic target-6 kDa (ESAT-6 ) 蛋白质和文化过滤蛋白质 10 (CFP-10 ) M。bovis。真核细胞的表示 plasmid pZ106,编码抗原 ESAT-6 和 CFP-10,结合了到各种各样的 PTD,被用来构造试验性的准备。我们的调查结果与 CFP-10 独自或在联合表明了那 VP22 : ESAT-6 熔化蛋白质能传播进包围 transfected 房间的房间单层的所有原子核。而激活 trans transcriptional PTD 出现了,熔化蛋白质和 8R 肽的有限交货是不能的交付熔化蛋白质进任何 untransfected 房间。我们证明了有熔化到 VP22 的准备的那免疫导致更高的抗体和干扰素 -- titer (P < 0.05 ) 。一起拿,我们的结果证明 MDV-1 VP22 用 DNA 疫苗在基因治疗和免疫用作潜在的有免疫力的 enhancer,为 M 的预防提供一条新奇途径。bovis 感染。 | Hongjun Chen Wei Wang Cuiping Song Shengqing Yu Chan Ding | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 4 |
| 10 | Increasing surface ozone concentrations in the background atmosphere of Southern China, 1994–2007显示文摘 | Wang T. Wei X. L. Ding A. J. Poon C. N. Lam K. S. Li Y. S. Chan L. Y. Anson M | 2009 | Atmospheric Chemistry and Physics2009，，175： | 3 |
| 11 | The East Asian summer monsoon: an overview显示文摘 | Ding Yihui Johnny C. L. Chan | 2005 | Meteorology and Atmospheric Physics (-)2005，，1： | 2 |
| 12 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 13 | Electrical properties of compositionally graded lead calcium titanate thin films 显示文摘 | Tang X G Chan H L W Ding A L | 2003 | Solid State Communications2003，127，910： | 1 |
| 14 | Supported mixed metal nanoparticles as electrocatalysts in low temperature fuel cells显示文摘 | Chan K Y Ding J Ren J | | 0，，04： | 1 |
| 15 | Development and evaluation of a trivalent Riemerella antipestifer inactive-ated vac?cine显示文摘 | Liu Haiwen Wang Xiaolan Ding Chan | 2013 | Clini Vac Immunol2013，20，5： | 1 |
| 16 | Novel phenohc glucoside, origanoside, protects against oxidative damage and modulates antioxidant enzyme activity 显示文摘 | Tzung- Han Chou Hsiou- Yu Ding Leong- Perng Chan | 2011 | Food Research International2011，6，44： | 1 |
| 17 | Model-Set Adaptation Using a Fuzzy Kalman Filter 显示文摘 | Zhen Ding Henry Leung Keith Chan Zhiwen Zhu | 2001 | Mathematical and Computer Modeling: (S0895-7177)2001，34，78： | 1 |
| 18 | Dynamic cluster formation using level set methods显示文摘 | Yip Andy M Ding Chris Chan Tony F | 2006 | IEEE Trans on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 19 | Processing effects on the microstructure and ferroelectric properties of Pb(Zr, Ti)O3 thin films prepared by sol- gel process 显示文摘 | Tang X G Chan H L W Ding A L | 2002 | Surface and Coating Technology2002，161，： | 1 |
| 20 | Energy and exergy analysis of simple solid-oxide fuel-cell power systems显示文摘 | S H Chan C F Low O L Ding | 2002 | Journal of Power Sources2002，103，： | 1 |
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