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| 1 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 2 | A mathematical model of gas flow during coal outburst initiation显示文摘A proposed concept of outburst initiation examines the release of a large amount of gas from coal seams resulted from disintegrating thermodynamically unstable coal organic matter(COM).A coal microstructure is assumed to getting unstable due to shear component appearance triggered by mining operations and tectonic activities considered as the primary factor while COM disintegration under the impact of weak electric fields can be defined as a secondary one.The energy of elastic deformations stored in the coal microstructure activates chemical reactions to tilt the energy balance in a“coal–gas”system.Based on this concept a mathematical model of a gas flow in the coal where porosity and permeability are changed due to chemical reactions has been developed.Using this model we calculated gas pressure changes in the pores initiated by gas release near the working face till satisfying force and energy criteria of outburst.The simulation results demonstrated forming overpressure zone in the area of intensive gas release with enhanced porosity and permeability.The calculated outburst parameters are well combined with those evaluated by field measurements. | Dmytro Rudakov Valeriy Sobolev | 2019 | International Journal of Mining Science and Technology2019，29，5： | 8 |
| 3 | Fine equiaxed β grains and superior tensile property in Ti-6Al-4V alloy deposited by coaxial electron beam wire feeding additive manufacturing显示文摘Coarse columnar β grains result in anisotropic mechanical properties in Ti alloys deposited by additive manufacturing. This study reports that Ti-6Al-4V alloy fabricated by coaxial electron beam wire feeding additive manufacturing presents a weak anisotropy, high strength and ductility. The superior tensile property arises from a microstructure with fine equiaxed β grains(EGβ), discontinuous grain boundary α phase and short intragranular α lamellae. A large region of fine EGβ arises from a special combination of the temperature gradient and solidification rate, and attractive α morphology is caused by solid phase transformations during interpass thermal cycling and post heat treatments. | Jiahua Zhang Yi Yang Sheng Cao Zhiqiang Cao Dmytro Kovalchuk Songquan Wu Enquan Liang Xi Zhang Wei Chen Fan Wu Aijun Huang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，10： | 5 |
| 4 | 科技型企业技术创业影响因素研究显示文摘科技型企业技术创业的关键是技术创业机会的识别和开发。然而以往文献对技术创业的研究,过多地关注影响技术创业机会开发的因素,而较少关注影响技术创业机会识别的因素。综合考虑影响技术创业机会识别和开发的各种因素,开发出一个模型,以描述影响科技型企业技术创业整个过程的各种因素。该模型为科技型企业提出切实可行的措施以提高技术创业率提供了一个更为全面的视角。 | 田茂利 杨甦宏 Kabachenko Dmytro | 2009 | 科技进步与对策2009，26，13： | 4 |
| 5 | The effect of cooling rates on the microstructure and mechanical properties of thermo-mechanically processed Ti–Al–Mo–V–Cr–Fe alloys显示文摘 | Mansur Ahmed Dmytro G. Savvakin Orest M. Ivasishin Elena V. Pereloma | 2013 | Materials Science & Engineering A2013，，： | 3 |
| 6 | Engineering layered/spinel heterostructure via molybdenum doping towards highly stable Li-rich cathodes显示文摘Li-rich layered oxide(LLO),e.g.,Li_(1.12)[Mn_(0.56)Ni_(0.16)Co_(0.08)]O_(2)(LRMO),is considered as a promising cathode material due to its superior Li-storage capability.However,the poor cycling stability and large voltage decay,which are related to the phase transition,limit its industrialization process.Herein,a Mo-doped LRMO(Li_(1.12)[Mn_(0.56)Ni_(0.16)Co_(0.08)]_(0.98)Mo_(0.02)O_(2),LRMO-Mo2.0%)was successfully synthesized via a simple combination of co-precipitation with high-temperature calcination for solving the mentioned above-disadvantages.Compared with the pristine counterpart,the as-prepared LRMO-Mo2.0%shows more excellent electrochemical performance in terms of rate capability(reversible capacity of 118 mA·h·g^(−1) at 5 C),cyclic ability(94.3%capacity retention after 100 cycles at 0.2 C)and discharge midpoint voltage decay(0.11 V after 100 cycles).Systematic investigation of structural evolution and electrochemical kinetics elucidate that the synergic effect of robust oxygen framework and layered/spinel heterostructure is the key to its performance improvement.Such synergy helps to stabilize the layered structure by curbing the structural transformation and oxygen escaping during the electrochemical cycling.This work paved the way for the simple and efficient preparation of highly stable LLO cathode materials. | Kun-Qi Geng Meng-Qian Yang Jun-Xia Meng Ling-Fei Zhou Yu-Qin Wang Sydorov Dmytro Qian Zhang Sheng-Wen Zhong Quan-Xin Ma | 2022 | Tungsten2022，4，4： | 2 |
| 7 | Electrochemiluminescence Imaging Techniques for Analysis and Visualizing显示文摘Electrochemiluminescence(ECL)-based imaging analysis is a dominant method to inspect the electrode composition,to study electrochemical reaction kinetics at a microscopic level,and also a rapid emerging technology in bioanalysis with high spatiotemporal resolutions,high-throughput and visualization characteristics.In comparison with other imaging microscopes,an optical excitation is not involved in imaging,thus the approach is free from background noise resulting in a low detec-tion limit.In this review work,the principle of ECL,its unique natures compared to other luminescence techniques were briefed at first.Then after,the progress and basic principles of ECL imaging were summarized.Furthermore,recent and representative advances of ECL imaging for visualizing and sensing applications were reviewed.Finally,the perspectives in ECL imaging for further perspective were discussed. | Tadesse Haile Fereja Fangxin Du Chao Wang Dmytro Snizhko Yiran Guan Guobao Xu | 2020 | Journal of Analysis and Testing2020，4，2： | 2 |
| 8 | A Petri net-based approach for automated goal-driven Web service composition 显示文摘 | DMYTRO Z | 2007 | Simulation2007，83，1： | 1 |
| 9 | Thermody- namic Laws of Impurities in the Titanium Sponge In- flow during its Produetion显示文摘 | Ivan Fedorovich Dmytro Olexandrovich | 2009 | Acta Mechanica Slova- ca2009，13，4： | 1 |
| 10 | Regional spillovers, eco- nomic growth, and the effects of economic integration 显示文摘 | DMYTRO HOLOD ROBERT R REED III | 2004 | Economics Letters2004，，85： | 1 |
| 11 | A method for optimization of time intervals between rolling cuts on sorting humps显示文摘Sorting humps are the main technical means providing the breaking-and making-up of freight trains.Automation of sorting process by implementing microprocessor control systems is the main direction of increasing hump yard capacity, enhancement of safety in trains breaking-up, improvement of working conditions on hump yards. However, for wider introduction of such systems at the humps, it is necessary to reduce their cost.One of the main tasks of hump control systems is the determination of the optimal cars exit speeds from the retarders. Its solution is significantly complicated because of the uncertainty of cars rolling resistance coefficient,wind velocity and direction, retarder control errors. The paper is aimed at solving the problem of searching for such cars exit speeds from the retarders that provide the longest time intervals between them at the switches. Implementation of this method will make it possible to improve the quality of sorting process as a whole by improving the software of microprocessor control systems for automatic humping, rather than by increasing their technical facilities,which as a result will reduce the cost of their construction and operation. The research results, when solving the problem of searching for cars exit speeds from the retarders, allow us to move from searching for the maximum of a nonlinear non-smooth function of two variables to solution of an equation with one variable, which significantly accelerates and simplifies the solution to the problem. | Dmytro Kozachenko Volodymyr Bobrovsky Yevhen Demchenko | 2018 | Journal of Modern Transportation2018，26，3： | 1 |
| 12 | Effect of chloroplastic overproduc-tion of ascorbate peroxidase on photo-synthesis and photoprotection in cotton leaves subjected to low temperature photoinhibition显示文摘 | DMYTRO K BARRY AL RANDY DA | 2003 | Plant Science2003，165，： | 1 |
| 13 | Calcium/calmodulin activation of two divergent glutamate decarboxylases from tobacco显示文摘 | DMYTRO P Y MICHAEL D M SRIYANI P OWEN R V C BARRY J S | 2003 | Journal of Experimental Botany2003，54，389： | 1 |
| 14 | Global supply chain network dynamics with multicriteria decision-making under risk and uncertainty显示文摘 | Anna N Dmytro M | 2005 | Transportation Research Part E : Logistics and Transportation Review2005，41，6： | 1 |
| 15 | Rehabilitation of executive functioning after focal damage to the cerebellum显示文摘 | Tom A S Brian L Dmytro R | 2008 | Neurorehabil Neural Repair2008，22，： | 1 |
| 16 | Enhanced photochemical light utilization and decreased chilling induced photoinhibition of photosystem Ⅱ in cotton overexpression gene encoding chloroplast-targeted antioxidant enzymes显示文摘 | KORNYEYEV D DMYTRO K BARRY A | 2001 | Physiol Plant2001，133，： | 1 |
| 17 | Resolving the deposit dilemma: A new DEA bank efficiency model显示文摘 | Dmytro Holod Herbert F. Lewis | 2011 | Journal of Banking and Finance2011，，11： | 1 |
| 18 | 基于词向量与TextRank的政策文本关键词汇抽取方法研究显示文摘通过对政策文本进行分析,设计了一种基于机器学习的关键词汇抽取方法,该方法可以自动从政策中提取关键性词语或短语。首先,从互联网采集相关政策文本并与维基百科数据融合,利用fastText构建词向量;其次,综合考虑词语的位置信息和词语之间的语义相似度,共同构建转移矩阵;最后选择得分最高的K个词语作为政策关键词。结果表明提出的方法抽取效果较好,实用性较高。 | 李晨 赵燕清 于俊凤 张铭君 DMYTRO LANDE | 2023 | 现代计算机2023，29，2： | 1 |
| 19 | Enhanced photo-chemical light utilization and decreased chilling-induced pbotoinhibition of photosystem II in cotton overexpression genes encoding chloroplast-targete dantioxidant enzymes显示文摘 | Kornyeyev D Dmytro K Barry A | 2001 | Physiol Plant2001，133，： | 1 |
| 20 | Thermody- namic laws of impurities in the titanium sponge inflow during its production 显示文摘 | Ivan Fedorovich Dmytro Olexandrovich | 2009 | Acta Mechanica Slovaca2009，13，4： | 1 |
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