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| 1 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 2 | Preparation and Swelling Properties of Poly ( NIPAM ) Minigel Particles Prepared by Inverse Suspension Polymerization 显示文摘 | Dowding P J Vincent B Williams E | 2000 | J Colloid and Interface Sei2000，221，26： | 1 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing(bTEFAP)显示文摘 | Dowd S E Wolcott R D Sun Y | 2008 | Pols One2008，3，10： | 1 |
| 5 | Sjogren's syndrome presenting as hypokalemic periodic paralysis 显示文摘 | DOWD J E LIPSKY P E | 1993 | Arthritis Rheum1993，36，12： | 1 |
| 6 | Altered mitogenactivated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenie rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons 显示文摘 | Echeverria V Ducatenzeiler A Dowd E | 2004 | Neurosci2004，129，： | 1 |
| 7 | United states department of agriculture-agricultural research service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops显示文摘 | CLEVELAND T E DOWD P F DESJARDINS A E | 2003 | Pest Manag Sci2003，59，67： | 1 |
| 8 | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus显示文摘 | Mellon J E Zelaya C A Dowd M K | 2011 | Letters in Applied Microbiology2011，52，4： | 1 |
| 9 | Teaching and physics education research: bridging the gap显示文摘 | James M Fraser Anneke L Timan Kelly Miller Jason E Dowd Laura Tucker Eric Mazur | 2014 | Reports on Progress in Physics2014，，3： | 1 |
| 10 | Effects of a nursing intervention on quality of life outcomes in post-surgical women with gynecological cancers显示文摘 | Mc Corkle R Dowd M Ercolano E | 2009 | Psycho Oncol2009，18，1： | 1 |
| 11 | Altered mito-gen-activated protein kinase signaling,tau hyperphosphorylationand mild spatial learning dysfunction in transgenic rats express-ing the beta-amyloid peptide intracellularly in hippocampal andcortical neurons显示文摘 | Echeverria V Ducatenzeiler A Dowd E | 2004 | Neuroscience2004，129，3： | 1 |
| 12 | Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens显示文摘 | Mellon J E Dowd M K Beltz S B | 2014 | Letters in Applied Microbiology2014，59，2： | 1 |
| 13 | Important source of marine secondary organic aerosol from biogenic amines 显示文摘 | Facchini M C Decesari S Rinaldi M Carbone C Finessi E Mircea M Fuzzi S Moretti F Tagliavini E Ceburnis D O'Dowd C D | 2008 | Environ Sci Technol2008，42，24： | 1 |
| 14 | Identification of the pollen determinant of S-RNase-mediated self-incompatibility显示文摘 | SIJACIC P WANG X SKIRPAN A L WANG Y DOWD P E MCCUBBIN A G HUANG S KAO T H | 2004 | Nature2004，429，6989： | 1 |
| 15 | Confirmation of the human-pathogenic microsporidia Enterocytozoon bienensi,Encephalitozoon intestinalis,and Vittaforma corneae in water显示文摘 | DOWD S E GERBA C P PEPPER I L | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 16 | Depreciation and amortization cost in activity-based costing system显示文摘 | DORAN D T DOWD J E | 1999 | Journal of Cost Management1999，，： | 1 |
| 17 | Discourse pressure, genre and grammatical alignment- after Du Bois显示文摘 | O'Dowd E | 1990 | Studies in Language1990，，2： | 1 |
| 18 | Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation显示文摘 | BAILEY M T DOWD S E GALLEY J D | 2011 | Brain Behavior and Immunity2011，25，3： | 1 |
| 19 | Effects of a nursing intervention on quality of life outcomes in post-surgical women with gynecological cancers显示文摘 | McCorkle R Dowd M Ercolano E | 2009 | Psychooncology2009，18，1： | 1 |
| 20 | Serum erythropoietin levels in children with leukemia 显示文摘 | DOWD M D MORGAN E R LANGMAN C B | 1997 | Med Pediatr Oncol1997，28，4： | 1 |
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