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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | The interaction of reaction-bonded silicon carbide and Inconel 600 with a nickel-based brazing alloy显示文摘 | Mcdermid J R Pugh M D Drew R A L | 1989 | Metallurgical Transactions A1989，20，： | 1 |
| 4 | Assessment of a rapid method,using soil cores, for estimating the amount and distribution of crop roots in the field 显示文摘 | Drew M C Saker L R | 1980 | Plant and Soil1980，55，： | 1 |
| 5 | Multiple paternity in a natural population of a wild tobacco fly, Bactrocera cacuminata (Diptera: Tephritidae), assessed by microsatellite DNA markers 显示文摘 | Song S D Drew R A Hughes J M | 2007 | Molecular Ecology2007，16，11： | 1 |
| 6 | Facilitation of oviposition behaviour of Bactrocera tryoini flies显示文摘 | PROKOPY R J REMING M C DREW R A I | 1999 | Journal of Insect Behavior1999，12，： | 1 |
| 7 | Carbon diox- ide capture using ionic liquid 1-butyl-3-methylimidazolium acetate 显示文摘 | Shiflett M B Drew D W Cantini R A | 2010 | Energy & Fuels2010，24，10： | 1 |
| 8 | Dentate gyms neurogenesis and depression显示文摘 | Sahay A Drew M R Hen R | 2007 | Prog Brain Res2007，163，： | 1 |
| 9 | Improvement of the mechanical properties in a nanocrystalline NiAl intermetallic alloy with Fe,Ga and Mo additions显示文摘 | ALBITER A SALAZAR M BEDOLLA E DREW R A L PEREZ R | | 0，，1： | 1 |
| 10 | Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma显示文摘 | Drayson M Tang LX Drew R | 2001 | Blood2001，97，： | 1 |
| 11 | Microstrural evolution during transient liquid phase bonding of Inconel 617 using Ni-Si-B filler metal显示文摘 | Jalilian F Jahazi M Drew R A L | 2006 | Mater Sci Eng A2006，423，： | 1 |
| 12 | Changes in the kinetics of phosphate and potassium absorption in nutrient-deficient harley roots measured by a solution-depletion technique显示文摘 | DREW M C SAKER L R | 1984 | Plants1984，160，： | 1 |
| 13 | Efficient organogenesisof an Australian passionfruit hybrid {Passiflora edulis x Passifloraedulis var, flavicarpa) suitable for gene delivery 显示文摘 | Hall R M Drew R A Higgins C M | 2000 | Aust J Bot2000，48，： | 1 |
| 14 | Complexes formed between the quadridentate,heterocyclic molecules 6,6′-bis-(5,6-dialkyl-1,2,4-triazin-3-yl)-2,2′-bipyridine(BTBP) and lanthanides(III):implications for the partitioning of actinides(III) and lanthanides(III)显示文摘 | Foreman M R Hudson M J Drew M G B | | 0，，13： | 1 |
| 15 | Mode of ac- tion of spray-dried porcine plasma in weanling pigs 显示文摘 | GATNAU R CAIN C DREW M | 1995 | J Anita Sci1995，73，1： | 1 |
| 16 | Serum free lightchain measurements for identifying and monitoring patients with nonsecretory multiple myeloma显示文摘 | Drayson M Tang LX Drew R | 2001 | Blood2001，97，9： | 1 |
| 17 | Chemical vapor deposition and characterization of amorphous Teflon fluoropolymerthin films 显示文摘 | SHARANGPANI R SINGH R DREWS M | 1997 | Journal of Electronic Materials1997，26，4： | 1 |
| 18 | Complexes formed between the quadridentate, heterocyclic molecules 6, 6' bis-(5, 6- diaikyl-1, 2, 4-triazin-3-yl )-2, 2'-bipyridine (BTBP) and lanthanides ( Ⅲ ) : Implications for the partitioning of actnides( Ⅲ) and lanthanides (Ⅲ)显示文摘 | FOREMAN M R HUDSON M J DREW M G B | 2006 | Dalton Transactions2006，13，： | 1 |
| 19 | Improving the tribological behavior of copper through novel Ti-Cu intermetallic coatings显示文摘 | BATENI M R ASHRAFIZADEH F SZPUNAR J A DREW R A L | 2002 | Wear2002，253，56： | 1 |
| 20 | Seasonal phenology of Bactrocera minax (Diptera:Tephritidae) in western Bhutan显示文摘 | Dorji C Clark A R Drew R A I Fletcher B S Loday P Mahat K Raghu S and Roming M C | | 0，，： | 1 |
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