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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 3 | 微生物对混凝土的侵蚀(英文)显示文摘微生物侵蚀会导致混凝土的严重破坏,尤其导致了城市污水收集和处理系统的过早破坏,使其需要提前修复。世界范围内的研究结果表明:处于污水和下水道污泥中的混凝土会遭受由硫酸盐、酸、CO2等导致的严重破坏。评述了混凝土处于利于细菌生长和生物降解环境中时的细菌、微生物侵蚀破坏过程。此外还分析了硫酸产生的机理(硫循环)、用于污水管道系统和农用工业的混凝土的受侵蚀破坏机理以及评价混凝土抵抗微生物侵蚀的方法。 | DUBRAVKA Bjegovic MARIJANA Serdar IGOR Cigrovski | 2010 | 硅酸盐学报2010，38，9： | 4 |
| 4 | 胰腺手术:演变及目前的个体化方案显示文摘胰腺癌的手术切除是患者延长生命的唯一机会,但胰腺手术目前仍然是一种技术上的挑战,并伴有术后并发症的风险,尤其是胰瘘。现在胰瘘发生的危险因素已被人们熟知,通过预防性用药及技术上的干预有可能阻止胰瘘的发生。随着术后护理的进步及影像学手段的干预,大多数常见的并发症可以保守治疗。这篇综述也试图对胰腺术后最佳管理方式所存在的争议进行阐述。 | Mario Zovak Dubravka Muzina Mi Goran Glavi 冯铁诚 李新营 | 2015 | 中国普通外科杂志2015，24，3： | 3 |
| 5 | Evaluation of survivin expression and its prognostic value in papillary thyroid carcinoma显示文摘 | Sonja Selemetjev Tijana Isic Dencic Ilona Marecko Jelena Jankovic Ivan Paunovic Svetlana Savin Dubravka Cvejic | 2013 | Pathology - Research and Practice2013，，： | 2 |
| 6 | An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor显示文摘 | Eva Lovric Dubravka Bobonj Hizak Melita Peric Balja Tanja Lenicek Bozo Kruslin | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 7 | FT-IR spectroscopy of lipoproteins—A comparative study显示文摘 | Dubravka Krilov Maja Balarin Marin Kosovi? Ozren Gamulin Jasminka Brnjas-Kraljevi? | 2009 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2009，，4： | 2 |
| 8 | A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice显示文摘 | Alexei A. Aravin Ravi Sachidanandam Deborah Bourc’his Christopher Schaefer Dubravka Pezic Katalin Fejes Toth Timothy Bestor Gregory J. Hannon | 2008 | Molecular Cell2008，，6： | 1 |
| 9 | Effect of high temperature on properties of steel slag aggregate concrete显示文摘 | Ivanka Netinger Damir Varevac Dubravka Bjegovi? Dragan Mori? | 2013 | Fire Safety Journal2013，，： | 1 |
| 10 | Utilisation of steel slag as an aggregate in concrete 显示文摘 | Inanka N Dubravka B Goran V | 2011 | Materials and Structures2011，44，9： | 1 |
| 11 | Significance of histopathological and molecular genetics investigations on the diagnosis and prognosis of astrocytic and oligodendroglial glioma显示文摘 | Dubravka CD Slobodan D Milica SG | 2002 | Archive of Oncology2002，10，3： | 1 |
| 12 | A comparison of fruit chemical characteristics of two wild grown rubus species from different locations of croatia显示文摘 | Purgar Dubravka Dujmovic Duralija Boris Voca Sandra | 2012 | Moleeules2012，17，10： | 1 |
| 13 | Significance of histopathological and molecular genetics investigations on the diagnosis and prognosis of astrocytic and oligodendroglial glioma显示文摘 | Dubravka C D Slobodan D Milica S G | 2002 | Archive of Oncology2002，10，： | 1 |
| 14 | Titanium alloy surface modification by excimer laser irradiation 显示文摘 | Milovanovi Dubravka S Petrovic Suzana M Shulepov Mikhail A | 2013 | Opt Laser Teehnoi2013，54，： | 1 |
| 15 | Measuring Thyro?globulin Concentrations in Patients with Differentiated Thyroid Car?cinoma显示文摘 | Svetlana Sa Dubravka Cv Ljiljana Mi | 2010 | Journal of Medical Biochemistry2010，29，4： | 1 |
| 16 | Defining and Comparing the Reading Comprehension Construct: A Cognitive-Psychometric Modeling Approach显示文摘 | Dubravka Svetina JoannaS. Gorin KikumiK. Tatsuoka | 2011 | International Journal of Testing2011，，1： | 1 |
| 17 | Immune,endocrine,and psychological responses in civilians displaced by war显示文摘 | Ante S Dubravka KH Sabina R | 2000 | Psychosom Med2000，62，： | 1 |
| 18 | Toughness testing of ultra high performance fiber reinforced concrete 显示文摘 | Marijan S Dubravka B | 2009 | Materials and Struetures2009，42，8： | 1 |
| 19 | Clinical and laboratory methods in diagnosis of acute appendicitis in children显示文摘 | Mojca G Stane R Dubravka V | 2007 | Croat Med J2007，48，3： | 1 |
| 20 | Immune, endocrine, displaeed by war psychosom显示文摘 | Ante S Dubravka KH Sabina R | 2000 | Medicine2000，62，6： | 1 |
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