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| 1 | Androgens and esophageal cancer: What do we know?显示文摘Significant disparities exist between genders for the development and progression of several gastrointestinal(GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors(AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome- poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer. | Olga A Sukocheva Bin Li Steven L Due Damian J Hussey David I Watson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 2 | Taxonomic revision of Aspergillus section Clavati based on molecular,morpholog-ical and physiological data显示文摘 | Varga J Due M Frisvad J C | 2007 | Studies in Mycology2007，59，： | 1 |
| 3 | Nonanesthesiologist-administered propofol versus midazolam and propofol,titrated to moderate sedation,for colonoscopy:a randomized controlled trial显示文摘 | Molina-Infante J Due?as-Sadornil C Mateos-Rodriguez JM | 2012 | Dig Dis Sci2012，57，9： | 1 |
| 4 | A new format for 5-axis tool path computation, using Bsphne curves 显示文摘 | Langeron J M Due E Lartigue C | 2004 | Computer-Aided Design2004，36，12： | 1 |
| 5 | Ab initio emulsion polymerization by RAFT- controlled self-assembly显示文摘 | CHRISTOPHER J Ferguson ROBERT J H ughes NGUYEN Due | 2005 | Macromolecules2005，38，6： | 1 |
| 6 | Surviving extreme hypercalcaemia--a case report and review of the literature显示文摘 | Marienhagen K Due J Hanssen T A | 2005 | J Intern Meal2005，258，1： | 1 |
| 7 | Exposure to carcinogenicpolycyclic aromatic compounds and health risk assessment fordiesel-exhaust exposed workers 显示文摘 | Sauvain J J Due T V Guillemin M | 2003 | International Archives ofOccupational and Environmental Heath2003，76，6： | 1 |
| 8 | Polyphasic taxonomy of Aspergillus section Usti显示文摘 | Houbraken J Due M Warga J | 2007 | Studies in Mycology2007，59，： | 1 |
| 9 | Mortality risk prediction with an updated Acute Physiology and Chronic Health Evaluation II score in critically ill obstetric patients: a cohort study 显示文摘 | PATERNINA - Caicedo A J ROJAS - SUAREZ J A DUE AS - CASTEL C | 2015 | J Intensive Care Med2015，30，2： | 1 |
| 10 | Magnetic resonance imaging of anterior cruciate ligament tears:evaluation of standard orthogonal and tailored paracoronal images显示文摘 | Due SR Zanctti M Kramer J | 2005 | Acta Radiol2005，46，： | 1 |
| 11 | Design and Controlof Warehouse Order Picking: A Literature Review显示文摘 | R De Koster T Le - Due K J Roodbergen | 2007 | EuropeanJournal of Operational Research2007，182，2： | 1 |
| 12 | Sulfation and reactivation characteristics of nine limestones 显示文摘 | Laursen K Due W Grace J B | 2000 | Fuel2000，79，15： | 1 |
| 13 | Cohabitation and marital status as pre- dictors of mortality: an eight year follow - up study 显示文摘 | LUND R DUE P MODVIG J HOLSETIN BE DAMSGAARD MT ANDERSEN PK | 2002 | Social Science & Medicine2002，55，： | 1 |
| 14 | Value of a new screening test from respiratory allergy: the Phadiatop 显示文摘 | Due J Peitrequin R Pecoud A | 1988 | Allergy1988，43，3： | 1 |
| 15 | Model- ing and optimization of acetic acid fer- mentation: A polynomial-based appro- ach显示文摘 | DUE AS I M S HORNERO J E J RO- DRIGUEZ A M C GARCIA I G | 2015 | Biochemical Engineering Jour- nal2015，99，： | 1 |
| 16 | Introduction to Ebola:The Virus and the Disease显示文摘 | Peters CJ Le Due J W | 1999 | J Inf Dis1999，，： | 1 |
| 17 | Feature Extraction Methods for Character Recognition: A Survey显示文摘 | Due T Q Anil K J Torfinn T | 1996 | Pattern Recognition1996，29，4： | 1 |
| 18 | TFF-1 expression is specific for lung primary in typical and atypical carcinoids : TFF-l-positive carcinoids are predominantly in peripheral location 显示文摘 | DUE Z GOLDSTRAW P ZACHARIAS J | 2004 | Hum Pathol2004，35，7： | 1 |
| 19 | Current data, experimental treatments and perspectives显示文摘 | Dueasse E Cosset J M Eschwege F et aL Hyperplasia of the arterial intima due to smooth muscle cell proliferation | 2003 | J Mal Vasc2003，28，3： | 1 |
| 20 | Roles of reactive oxygen species in interactions between plants and pathogens显示文摘 | Nandini P Shetty Hans J Lyngs J rgensen Jens Due Jensen David B Collinge H Shekar Shetty | 2008 | European Journal of Plant Pathology2008，121，3： | 1 |
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