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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | The Dual Association between Lymphoma and Autoimmunity显示文摘 | Ehrenfeld M Abu Shakra M Buskila D | 2001 | Blood Cells Mol Dis2001，27，4： | 1 |
| 3 | Cancer and antoimmunity; autoimmune and rheumatic features in patients with malignancies显示文摘 | Abu - Shakra M Buskila D Ehrenfeld M | 2001 | Ann Rheum Dis2001，60，： | 1 |
| 4 | Stress, self- efficacy and quali- ty of life in cancer patients显示文摘 | Kreitler S Peleg D Ehrenfeld M | 2007 | Psycho Oncology2007，16，4： | 1 |
| 5 | cancer and autoimmunity:autoimmune and rheumatic features in patients with malignancies显示文摘 | Abu-shakra M Buskila D Ehrenfeld M etal | 2001 | Ann Rheum Dis2001，60，： | 1 |
| 6 | Human population control : the missing agenda显示文摘 | MEFFE G EHRLICH A EHRENFELD D | 1993 | Conserv Biol1993，7，1： | 1 |
| 7 | Coping with preoperative anxiety in cesarean section: physiological, cognitive, and emotional effects of listening to favorite music显示文摘 | Jonathan Kushnir P H D Ahuva Friedman R N Mally Ehrenfeld R N | 2012 | Women''s Health Nursing2012，2，39： | 1 |
| 8 | Identification of pheromone-induced surface proteins in Streptococcus faecalis and evidence of a role for lipoteichoic acid in formation of mating aggregates 显示文摘 | EHRENFELD E E KESSLER R E CLEWELL D B | 1986 | J Bacteriol1986，168，1： | 1 |
| 9 | The dual as- sociation between lymphoma and autoimmunity 显示文摘 | Ehrenfeld M Abu Shakra M Buskila D | 2001 | Blood Cells Mol Dis2001，27，： | 1 |
| 10 | Urban conservation andenvironmental protection in China:a major effort by the ChineseAcademy of Sciences显示文摘 | Ehrenfeld D Yu S Zhu Y G | 2009 | Conservation Biology2009，23，3： | 1 |
| 11 | Endangered species 'hot spots'显示文摘 | Ehrenfeld D Noss R F Meffe G K | 1997 | Science1997，276，： | 1 |
| 12 | Stress,self-efficacy and quality of life in cancer patients显示文摘 | Kreitler S Peleg D Ehrenfeld M | | 0，，04： | 1 |
| 13 | Cancer and autoimmunity;autoimmune and rheumatic features in patients with malignancies显示文摘 | Abu-Shakra M Buskila D Ehrenfeld M | 2001 | Ann Rheum Dis2001，60，： | 1 |
| 14 | Carotid plaque hemorrhage, its role in production of cerebral ischemia显示文摘 | Lusby R J Ferrell L D Ehrenfeld W K | 1982 | Arch Surg1982，117，11： | 1 |
| 15 | Formation of the poliovirus replication complex requires coupled viral translation,vesicle production,and viral RNA synthesis显示文摘 | Egger D Teterina N Ehrenfeld E | 2000 | Journal of Virology2000，74，14： | 1 |
| 16 | Endangered species'hot spots'显示文摘 | Ehrenfeld D Noss R F Meffe G K | 1997 | Science1997，276，： | 1 |
| 17 | Stress,self efficacy and quality of life in cancer patients显示文摘 | Kreitter S Peleg D Ehrenfeld M | 2007 | Psychooncology2007，16，4： | 1 |
| 18 | Cancer and autoimmunity:autoimmune and rheumatic features in patients with malignancies显示文摘 | Buskila D Ehrenfeld M | 2001 | Ann Rheum Dis2001，60，5： | 1 |
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