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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | 由两倍汽球 enteroscopy 的小肠 polypectomy : 与优先的囊内视镜检查法的关联显示文摘 AIM:To investigate the feasibility of small bowel polypectomy using double balloon enteroscopy and to evaluate the correlation with capsule endoscopy(CE).METHODS:This is a retrospective review of a single tertiary hospital.Twenty-five patients treated by enteroscopy for small bowel polyps diagnosed by CE or other imaging techniques were included.The correlation between CE and enteroscopy(correlation coefficient of Kendall for the number of polyps,intra-class coefficient for the size and coefficient of correlation kappa for the location) was evaluated.RESULTS:There were 31 polypectomies and 12 endoscopic mucosal resections with limited morbidity and no mortality.Histological analysis revealed 27 hamartomas,6 adenomas and 3 lipomas.Strong agreement between CE and optical enteroscopy was observed for both location(Kappa value:0.90) and polyp size(Kappa value:0.76),but only moderate agreement was found for the number of polyps(Kendall value:0.47).CONCLUSION:Double balloon enteroscopy is safe for performing polypectomy.Previous CE is useful in selecting the endoscopic approach and to predicting the difficulty of the procedure. | Gabriel Rahmi Elia Samaha Camille Lorenceau-Savale Bruno Landi Joёl Edery Thibault Manière Jean-Marc Canard Georgia Malamut Gilles Chatellier Christophe Cellier | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 3 | Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy?显示文摘 | Diane Goéré David Malka Dimitri Tzanis Vinicius Gava Valérie Boige Clarisse Eveno Léon Maggiori Frédéric Dumont Michel Ducreux Dominique Elias | 2013 | Annals of Surgery2013，，6： | 2 |
| 4 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 5 | Silent diabetic nephropathy显示文摘AIM: To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy(DN) and its possible associated factors.METHODS: Clinical and histological data of 60 patients diagnosed with diabetic nephropathy were retrospectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The final event was defined as renal replacement therapy(RRT) initiation or progression of chronic kidney disease(CKD), according to the KDIGO 2012 definition of a decrease in CKD category and a decrease in GFR of 25% or more. RESULTS: A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a median age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, although in 13 patients, it was less than 5 years. A total of 62% of patients reached the final event in a mean period of 3.4 years(95%CI: 2.1-4.7), with 21 of them requiring dialysis. The factors that were independently associated with renal survival were estimated glomerular filtration rate(e GFR) at the time of biopsy, cardiovascular disease(CVD) history and Hb A1 c less than 7%. Therefore, for each 10 m L/min per 1.73 m2 reduction in e GFR, we obtained a DN progression risk of HR = 2(1.3-3.0)(P = 0.001); patients with CVD were at greater risk for DN progression(HR = 2.8, 1.1-7.1, P = 0.032), and CKD patients with Hb A1 c < 7% demonstrated greater renal risk than patients with Hb A1 c ≥ 7%, with an HR of 2.9(1.0-8.4)(P = 0.054).CONCLUSION: A past history of CVD is a risk factor for DN progression. Levels of Hb A1 c less than 7% could favor an e GFR decrease in these patients. | Katia López-Revuelta Patricia Pea Galdo Ramona Stanescu Leticia Parejo Carmen Guerrero Elia Pérez-Fernández | 2014 | World Journal of Nephrology2014，3，1： | 2 |
| 6 | Risk factors for thromboembolic events in renal failure 显示文摘 | D'Elia J A Weinrauch L A | 2005 | Int J Cardiol2005，101，1： | 1 |
| 7 | Predicting the optical performance of the space interferometry mission using a model- ing,testing, and validation methodology 显示文摘 | Basdogan I Elias L M Dekens F | 2007 | Journal of Vibration and Acoustics2007，129，2： | 1 |
| 8 | Synapse-specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins 显示文摘 | Elias G Funke L Stein V | 2006 | Neuron2006，52，2： | 1 |
| 9 | Morphology and rheology of immiscible polymer blends filled with silica nanoparticles 显示文摘 | ELIAS L FENOUILLOT F MAJESTE J C | 2007 | Polymer2007，48，20： | 1 |
| 10 | Photosensor de- vice based on few-layered WS2 films显示文摘 | Perea-L6pez N Elias A L Berkdemir A | 2013 | Advanced Functional Materials2013，23，44： | 1 |
| 11 | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women显示文摘 | Innis S M Elias S L | 2003 | Am J Clin Nutr2003，77，： | 1 |
| 12 | A carrot leucine-rich- repeat protein that inhibits ice recrystallization显示文摘 | Worrall D Elias L Ashford D | 1998 | Science1998，282，5386： | 1 |
| 13 | Acute lateral patel-lar dislocation at M R imaging:injury patterns of medialpatellar soft-tissue restraints and osteochondral injuries ofthe inferomedial patella显示文摘 | Elias D A White L M Fithian D C | 2002 | Radiology2002，225，3： | 1 |
| 14 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 15 | Suppression of microRNA accumulation via RNA interference inAr-abidopsis thaliana显示文摘 | Vaistij F E Elias L George G L | 2010 | Plant Moleculariology2010，73，： | 1 |
| 16 | Evaluation of two new neuropsychological tests designed to minimize cultural bias in the assessment of HIV-1 seropositive persons: a WHO study 显示文摘 | Maj M D' Elia L Satz P | 1993 | Arch Clin Neuropsychol1993，8，2： | 1 |
| 17 | The role of BCR/ABL isoforms in the presentation and outcome of patients with Philadelphia - positive acute lymphoblastic leukemia:a seven - year update of the GIMEMA 0496 trial 显示文摘 | Cimino G Pane F Elia L | 2006 | Haematologica2006，91，3： | 1 |
| 18 | To sreen or not to screenfor adult malnutrition显示文摘 | ELIA M ZELLIPOUR L STRATTON R J | 2005 | Clinical Nutrition2005，24，8： | 1 |
| 19 | Vein valve transplant显示文摘 | Tahefi SA Lazer L Elias SM | 1982 | Surgery1982，91，1： | 1 |
| 20 | In vivo imaging of cancer biomarkers using aetivatable molecular probes显示文摘 | Elias D R Thorek D L J Chen A K | 2008 | Caneer Biomarkers2008，4，6： | 1 |
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