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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 4 | Nuclear run-on analysis of var gene expression in Plasmodium falciparum 显示文摘 | Elise S Judith M P Cecilia P S | 2007 | Mol Biochem Parasitol2007，153，2： | 1 |
| 5 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Elise N Rowan Gordon D Murray Anil Gholkar Patrick M Mitchell | 2013 | The Lancet2013，，： | 1 |
| 6 | Proteomics and ovarian cancer: implications for diagnosis and treatment: a critical review of the recent literature显示文摘 | Edwin M Posadas Ben Davidson Elise C Kohn | 2004 | Current Opinion in Oncology2004，，： | 1 |
| 7 | New silicon architectures by gold-assisted chemical etching显示文摘 | Mikhael B Elise B Xavier M | 2011 | Appl Mater Interf2011，3，10： | 1 |
| 8 | Least possible time paths in stochastic,time-varying networks显示文摘 | Hani S M | 1998 | Computers and Operations Research1998，25，12： | 1 |
| 9 | Path comparisons for a priori and time-adaptive decisions in stochastic,time-varying networks显示文摘 | Hani S M | 2003 | European Journal of Operational Research2003，146，： | 1 |
| 10 | Path Comparisons for a Priori and Timeadaptive Decisions in Stochastic, Time-Varying Networks 显示文摘 | Elise D M Hani S M | 2003 | European Journal of Operational Research2003，，146： | 1 |
| 11 | Identifivation of competencies for professionals in open innovation teams 显示文摘 | Elise du Chatenier Jos A M Verstegen Harm J A Biemans | 2010 | R&D Management2010，40，3： | 1 |
| 12 | PMWS:experimental model and co-infections显示文摘 | Allan G M McNeilly F Elise J | 2004 | Vet Microbiol2004，98，2： | 1 |
| 13 | Isolation of RNA and DNA from rice seedling mitochondria 显示文摘 | MICHAEL M R ELISE D CHAZ A | 1988 | Rice Genet Newsl1988，5，： | 1 |
| 14 | Clinical Practice:Chronic fatigue syndrome显示文摘 | CHARLOTTE L SANNE L ELISE M | 2013 | J Pediatr2013，172，10： | 1 |
| 15 | A Two-level, protocol-based ap- proach to controlling autonomous oceanographic sampling net- works显示文摘 | Roy M Turner Elise H Turner | 2001 | Oceanic Engineering2001，26，4： | 1 |
| 16 | Detection of different variants of ostreid herpesvirus 1 in the pacific oyster, crassostrea gigas between 2008 and 2010显示文摘 | Claire M Elise O Emmanuelle T | 2011 | Virus Research2011，160，： | 1 |
| 17 | Tumor angiogenesis in advanced stage ovarian carcinoma 显示文摘 | Helen C Hollingsworth Elise C Kohn Seth M Steinberg | 1995 | Am J Pathol1995，147，1： | 1 |
| 18 | Risk and managementof blood-borne infections in health care workers显示文摘 | Elise M B Ian T W Craig N S | 2000 | Clin Microbiol Rev2000，13，3： | 1 |
| 19 | Human intoxication by microcystins during renal dialysis treatment in Caruaru—Brazil显示文摘 | Sandra M.F.O Azevedo Wayne W Carmichael Elise M Jochimsen Kenneth L Rinehart Sharon Lau Glen R Shaw Geoff K Eaglesham | 2002 | Toxicology2002，，： | 1 |
| 20 | Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition显示文摘 | Anna-Karin Bostr?m Christina M?ller Elise Nilsson Peter Elfving H?kan Axelson Martin E. Johansson | 2012 | Human Pathology2012，，5： | 1 |
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