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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | A role of the ubiquitin-proteasome system in neuropathic pain显示文摘 | ANDREW M GORDON B M EMER M | 2002 | J Neurosci2002，22，4： | 1 |
| 3 | Simultaneous Multithreading: a Platform for Next-Generation Proeessors显示文摘 | Eggers S J Emer J S Levy H M | 1997 | IEEE Micro1997，17，5： | 1 |
| 4 | Investigation of metallic and carbon bibre PEEK fracture fixation devixes for three- part proximal humeral fracture 显示文摘 | Emer MF Jim K Hannan M | 2013 | Med Eng Phys2013，35，6： | 1 |
| 5 | Thromboxane and the thromboxane receptor in cardiovascular disease显示文摘 | Emer M Smyth | 2010 | Clin Lioidol2010，5，2： | 1 |
| 6 | Polyaniline Solution, Film and Oxidation State 显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，1： | 1 |
| 7 | Effect of pH on growth kinetics and sulphide toxicity thresholds of a range of methanogenic,syntrophic and sulphate-reducing bacteria显示文摘 | Thdrose M Ronan K Emer C | 1998 | Process Biochemistry1998，33，5： | 1 |
| 8 | Simultaneous multithreading: a platform for next-generation processors显示文摘 | EGGEGS S J EMER J S LEVY H M LO J L STAMM R L TULLSEN D M | 1997 | IEEE Micro1997，17，5： | 1 |
| 9 | Polyaniline soluetion, film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，： | 1 |
| 10 | Polyaniline solution, film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Mol Cryst1988，160，： | 1 |
| 11 | Polyaniline Soluetion, film and Oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Molcryst1988，160，： | 1 |
| 12 | Simultaneous multithreading:A platform fornext-generation processors显示文摘 | EGGERS S J EMER J S LEVY H M | 1997 | IEEE Micro1997，17，5： | 1 |
| 13 | Mutations in the basic core prorooter and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B 显示文摘 | Friedt M C emer P Lausch E | 1999 | Hepatology1999，29，4： | 1 |
| 14 | Optimal drug and gene delivery in cancer cells by ultrasound induced cavitation 显示文摘 | Larina I V Emers B M Esenaliev R O | 2005 | Anticancer Res2005，25，1： | 1 |
| 15 | Polyaniline solution,film and oxidation state显示文摘 | Angelopoulos M Astunas G E Emer S P | 1988 | Mol Cryst1988，160，： | 1 |
| 16 | Investigation of metallic and carbon fibre PEEK fracture fixa- tion devices for thrempart proximal humeral fractures显示文摘 | Emer M Feerick Jim Kennedy Hannan Mullett | 2013 | Medi- cal engineering and physics2013，35，6： | 1 |
| 17 | A laboratory experiment demon- strating the dynamic character of membranes 显示文摘 | PUGH M E EMERIC S | 2000 | Bio- chem Mol Biol Edu2000，28，6： | 1 |
| 18 | Effect of pH on growth kinetics and sulphide toxicity thresholds of a range of methanogenic, syntrophic and sulphate-reducing bacteria 显示文摘 | Vincent O F Thdrose M Ronan K Emer C | 1998 | Process Biochemistry1998，33，5： | 1 |
| 19 | Progressive Familial Intrahepatic Cholestasis Type1,Is Associated With Decreased Farnesoid X Receptor Activity显示文摘 | Chen F Ananthanarayanan M Emer S | 2004 | Gastroenterology2004，126，： | 1 |
| 20 | Simultaneous Multithreading:A Platform for Next-generation Processors显示文摘 | Eggers S J Emer J S Levy H M | 1997 | IEEE Micro1997，17，5： | 1 |
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