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| 1 | NAFLD fibrosis score:A prognostic predictor for mortality and liver complications among NAFLD patients显示文摘AIM:To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease(NAFLD) fibrosis score can predict all-cause mortality,cardiac complications,and/or liver complications of patients with NAFLD over long-term follow-up.METHODS:A cohort of well-characterized patients with NAFLD diagnosed during the period of 1980-2000 was identified through the Rochester Epidemiology Project.The NAFLD fibrosis score(NFS) was used to separate NAFLD patients with and without advanced liver fibrosis.We used the NFS score to classify the probability of fibrosis as <-1.5 for low probability,>-1.5 to < 0.67 for intermediate probability,and > 0.67 for high probability.Primary endpoints included allcause death and cardiovascular-and/or liver-related mortality.From the 479 patients with NAFLD assessed,302 patients(63%) greater than 18 years old were included.All patients were followed,and medical charts were reviewed until August 31,2009 or the date when the first primary endpoint occurred.By using a standardized case record form,we recorded a detailed history and physical examination and the use of statins and metformin during the follow-up period.RESULTS:A total of 302/479(63%) NAFLD patients(mean age:47 ± 13 year) were included with a followup period of 12.0 ± 3.9 year.A low probability of advanced fibrosis(NFS <-1.5 at baseline) was found in 181 patients(60%),while an intermediate or high probability of advanced fibrosis(NSF >-1.5) was found in 121 patients(40%).At the end of the follow-up period,55 patients(18%) developed primary endpoints.A total of 39 patients(13%) died during the follow-up.The leading causes of death were non-hepatic malignancy(n = 13/39;33.3%),coronary heart disease(CHD)(n = 8/39;20.5%),and liver-related mortality(n = 5/39;12.8%).Thirty patients had new-onset CHD,whereas 8 of 30 patients(27%) died from CHD-related causes during the follow-up.In a multivariate analysis,a higher NFS at baseline and the presence of new-onset CHD were significantly predictive of death(OR = 2.6 and 9.2,respectively;P < 0.0001).Our study showed a significant,graded relationship between the NFS,as classified into 3 subgroups(low,intermediate and high probability of liver fibrosis),and the occurrence of primary endpoints.The use of metformin or simvastatin for at least 3 mo during the follow-up was associated with fewer deaths in patients with NAFLD(OR = 0.2 and 0.03,respectively;P < 0.05).Additionally,the rate of annual NFS change in patients with an intermediate or high probability of advanced liver fibrosis was significantly lower than those patients with a low probability of advanced liver fibrosis(0.06 vs 0.09,P = 0.004).The annual NFS change in patients who died was significantly higher than those in patients who survived(0.14 vs 0.07,P = 0.03).At the end of the follow-up,we classified the patients into 3 subgroups according to the progression pattern of liver fibrosis by comparing the NFS at baseline to the NFS at the end of the followup period.Most patients were in the stable-fibrosis(60%) and progressive-fibrosis(37%) groups,whereas only 3% were in the regressive fibrosis.CONCLUSION:A higher NAFLD fibrosis score at baseline and a new onset of CHD were significantly predictive of death in patients with NAFLD. | Sombat Treeprasertsuk Einar Bjrnsson Felicity Enders Sompongse Suwanwalaikorn Keith D Lindor | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 2 | Forming asymmetric C-C bond显示文摘 | Enders D | 1981 | Chemtech1981，11，： | 1 |
| 3 | Wide-Area Traffic Monitoring With the SAR/GMTI System PAMIR 显示文摘 | Cerutti-Maori D Klare J Brenner A R and Ender J H G | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，10： | 1 |
| 4 | Chiral quaternary phosphonium salts : a new class of organocatalysts 显示文摘 | Enders D Nguyena T V | 2012 | Organic & Biomolecular Chemistry2012，10，28： | 1 |
| 5 | Phase behavior of quaternary systems containing carbohydrate surfactants-wateroil-cosurfactant显示文摘 | Hantzschel D Enders S Kahl H | 1999 | Physical Chemistry Chemical Physics1999，1，24： | 1 |
| 6 | Surface-enhanced ATR-IR spectroscopy with interface-grown plasmonic gold-island films near the percolation threshold显示文摘 | Enders D Nagao T Pucci A | 2011 | Physical Chemistry Chemical Physics2011，13，11： | 1 |
| 7 | Process Control Performance:Not at Good as You Think显示文摘 | ENDER D B | 1993 | Control Engineering1993，40，10： | 1 |
| 8 | CEO Narcissism, Audience Engagement, and Organizational Adoption of Technological Dis-continuities 显示文摘 | Gerstner W C Knig A Enders A Hambrick D C | 2013 | Administrative Science Quarterly2013，58，2： | 1 |
| 9 | Process control performance : Not at good as you think 显示文摘 | Ender D B | 1993 | Control Engineering1993，13，2： | 1 |
| 10 | Asymmetric syn-thesis of Jaspine B ( Pachastrissamine) via an organocatalytic al-dol reaction as key step 显示文摘 | ENDERS D TERTERYAN V PALECEK J | 2008 | Synthesis2008，，14： | 1 |
| 11 | Optimum SAR/GMTI processing and its application to the radar satellite RADARSAT-2 for traffic monitoring显示文摘 | Cerutti-Maori D Gierull C H and Ender J H G | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，10： | 1 |
| 12 | Surface-enhanced ATR-IR spectroscopy with interface-grown plasmonic gold-island films near the percolation threshold显示文摘 | Enders D Nagao T Pucci A | 2011 | Phys Chem Chem Phys2011，13，11： | 1 |
| 13 | Synthesis and properties of the enantiomers of the two artifical fragrances lilial and methylundecanal 显示文摘 | Enders D Dyker H | 1990 | Liebigs Ann Chem1990，11，： | 1 |
| 14 | An efficient nucleophilic carbene catalyst for the asymmetric benzoin condensation显示文摘 | Enders D Kallfass U | 2002 | Angewandte Chemie International Edition2002，41，10： | 1 |
| 15 | Experimental verification of SAR-GMTI improvement through antenna switching显示文摘 | Cerutti-Maori D Gierull C H and Ender J H G | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，4： | 1 |
| 16 | Harvesting energy from t he marine sediment-water interface Ⅱ: Kinetic activity of anode materials显示文摘 | Lowy D A ender L M Zeikus J G ct al | 2006 | BiosensorsandBioeleetronics2006，21，11： | 1 |
| 17 | Nucleophilic Carbenes in Asymmetric Organocatalysis显示文摘 | Enders D Balensiefer T | 2004 | Acc Chem2004，37，8： | 1 |
| 18 | Process Control Performance:Not at Good as You Think显示文摘 | Ender D B | 1993 | Control Engineering1993，，： | 1 |
| 19 | New N-heterocyclic carbene palladium com- plex/ionic liquid matrix immobilized on silica : Application as re- coverable catalyst for the heck reaction显示文摘 | Karimi B Enders D | 2006 | Organic Letters2006，8，6： | 1 |
| 20 | Preparation, structure, and reactivity of 1,3,4-triphenyl-4,5-dihydro-lH-l,2,4- triazol-5-ylidene, a new stable carbene 显示文摘 | Enders D Breuer K Raabe G et O1 | 1995 | Angew Chem Int Ed1995，34，： | 1 |
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