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5篇 您的检索式:作者名="Edward Beamer"
    题名 作者 年代 出处 被引量
1Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse显示文摘Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the brain.While increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely explored.In this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein EGFP.The results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and oligodendrocytes.Colocalization of P2X7-EGFP with cell type-specific markers was not detected in neurons or astrocytes.These data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel 2020Neuroscience Bulletin2020,36,11:3
2Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer显示文摘Jason J. Hall M.D. Brian W. Loggie M.D. Perry Shen M.D. Staci Beamer B.S. L. Douglas Case Ph.D. Richard McQuellon Ph.D. Kim R. Geisinger M.D. Edward A. Levine M.D 2004Journal of Gastrointestinal Surgery2004,,4:1
3Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer显示文摘Jason J. Hall Brian W. Loggie Perry Shen Staci Beamer L. Douglas Case Richard McQuellon Kim R. Geisinger Edward A. Levine 2004Journal of Gastrointestinal Surgery2004,,4:1
4Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer显示文摘Jason J. Hall M.D. Brian W. Loggie M.D. Perry Shen M.D. Staci Beamer B.S. L. Douglas Case Ph.D. Richard McQuellon Ph.D. Kim R. Geisinger M.D. Edward A. Levine M.D 2004Journal of Gastrointestinal Surgery2004,,4:1
5Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer显示文摘Jason J. Hall M.D. Brian W. Loggie M.D. Perry Shen M.D. Staci Beamer B.S. L. Douglas Case Ph.D. Richard McQuellon Ph.D. Kim R. Geisinger M.D. Edward A. Levine M.D 2004Journal of Gastrointestinal Surgery2004,,4:1
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