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| 1 | Structural modifications of Helicobacter pylori lipopolysaccharide:An idea for how to live in peace显示文摘In this review,we discuss the findings and concepts underlying the'persistence mechanisms'of Helicobacter pylori(H.pylori),a spiral-shaped,Gram-negative rod bacterium that was discovered as a gastric pathogen by Marshall and Warren in 1984.H.pylori colonizes the gastric mucosa of nearly half of the human population.Infections appear in early childhood and,if not treated,persist for life.The presence or absence of symptoms and their severity depend on multiple bacterial components,host susceptibility and environmental factors,which allow H.pylori to switch between pathogenicity and commensalism.Many studies have shown that H.pylori components may facilitate the colonization process and the immune response of the host during the course of H.pylori infection.These H.pylori-driven interactions might result from positive or negative modulation.Among the negative immunomodulators,a prominent position is occupied by a vacuolating toxin A(VacA)and cytotoxin-associated gene A(CagA)protein.However,in light of the recent studies that are presented in this review,it is necessary to enrich this panel with H.pylori lipopolysaccharide(LPS).Together with CagA and VacA,LPS suppresses the elimination of H.pylori bacteria from the gastric mucosa by interfering with the activity of innate and adaptive immune cells,diminishing the inflammatory response,and affecting the adaptive T lymphocyte response,thus facilitating the development of chronic infections.The complex strategy of H.pylori bacteria for survival in the gastric mucosa of the host involves both structural modifications of LPS lipid A to diminish its endotoxic properties and the expression and variation of Lewis determinants,arranged in O-specific chains of H.pylori LPS.By mimicking host components,this phenomenon leaves these bacteria'invisible'to immune cells.Together,these mechanisms allow H.pylori to survive and live for many years within their hosts. | Magdalena Chmiela Karolina Rudnicka Eliza Miszczyk | 2014 | World Journal of Gastroenterology2014，20，29： | 15 |
| 2 | Effect of music on procedure time and sedation during colonoscopy:A meta-analysis显示文摘AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad’s scale. The random effect model was used to pool the effect from individual trials and the Cohen Q-statistic was used to determine heterogeneity. Egger’s regression was used to detect publication bias. RESULTS: Eight studies with 722 subjects were included in this meta-analysis. The combined mean difference for the time taken for the colonoscopy procedure between the music and control groups was -2.84 with 95% CI (-5.61 to -0.08), implying a short time for the music group. The combined mean difference for the use of sedation was -0.46 with 95%CI (-0.91 to -0.01), showing a significant reduction in the use of sedation in the music group. Heterogeneity was observed in both analyses but no publication bias was detected. CONCLUSION: Listening to music is effective in reducing procedure time and amount of sedation during colonoscopy and should be promoted. | Wilson WS Tam Eliza LY Wong Sheila F Twinn | 2008 | World Journal of Gastroenterology2008，14，34： | 12 |
| 3 | Successful conservative management with methotrexate and mifepristone of cervical pregnancy显示文摘This study investigated possible effective treatments for cervical pregnancy, a rare form of ectopic pregnancy. The clinical records of 11 cases of ectopic pregnancy admitted to the Third Affiliated Hospital of Sun Yat-sen University from 1998 to 2010 were analyzed. All patients were treated with intermuscular injection of methotrexate (MTX, 50 mg), and oral mifepristone (25 mg, bid). All cases were successfully cured by conservative treatments using methotrexate plus mifepristone. Cervical pregnancy is a contributive factor to mutiple abortions and curettages. Methotrexate plus mifepristone, curettage through hysteroscopy and intracervical obturation with gauze are effective treatments of cervical pregnancy without the need for surgical intervention. | Eliza Shrestha | 2011 | The Journal of Biomedical Research2011，25，1： | 11 |
| 4 | Type D personality negatively associated with self-care in Chinese heart failure patients显示文摘 | Xi CAO Xiu-Hua WANG Eliza ML Wong Choi Kai Chow Sek Ying Chair | 2016 | Journal of Geriatric Cardiology2016，13，5： | 9 |
| 5 | Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong显示文摘 | Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong Siu Wai Tang | 2016 | Journal of Geriatric Cardiology2016，13，5： | 5 |
| 6 | Semen analysis standardization: is there any problem in Polish laboratories?显示文摘学习的目的是决定对世界健康组织的波兰的实验室的依从的度() 建议,关于精液分析方法论。关于精液分析的方法请求信息的调查被散布到 55 个实验室的雇员。参予了外部 seminological 专题讨论会的回答者(31 %) 被称为证明回答者(CR ) ,留下(69 %)—非证明的回答者(NCR ) 。仅仅一个实验室(6 %) 在 CR,在 NCR 的组和没有遵循为方法和设备的指南使用了谁评估精液的体积,精子活动性,集中,活力和形态学。大多数问题具有体积测量(称方法被 17 % 报导;CR 和 10 %NCR ) 并且为精子形态学染色方法(Papanicolau 或 Diff-Quik 在 33 % 被发现;CR 和 23 %NCR ) 。三点或四点的 A 精子活动性分级被回答者的多数使用;然而, 17 %CR 和 37 %没 NCR 使用一个实验室柜台计算精子。尽管一个 haemocytometer 方法被 80 % 使用;在每个组的实验室,改进 Neubauer 房间仅仅由 42 % 被使用;CR 和 19 %NCR。在每个组, 24 %没实验室执行活力测试。程序的错误和二的可互换的利用或甚至三个方法在两个组被观察分析一个给定的参数。结果为方法的标准化显示需要并且连续,在波兰的实验室在精液分析训练统一。 | Renata Walczak-Jedrzejowska Katarzyna Marc hlewsks Elzbieta Oszukowska Eliza Filipiak Leszek Bergier Jolanta Slowikowska-Hilczer | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 7 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 8 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 9 | Intestinal pseudo-obstruction caused by herpes zoster:Case report and pathophysiology显示文摘Herpes zoster(HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. Peripheral neuropathy may reveal segmental motor paresis of either upper or lower limbs, the abdominal muscles or the diaphragm. We report the case of a 62-year-old male patient who presented with abdominal distention and cutaneous vesicular eruption on the left side of the abdominal wall. Plain X-rays and computed tomography scan showed distended small bowel. A diagnosis of intestinal pseudo-obstruction was made secondary to segmental paresis of the small intestine and visceral neuropathy. Conservative management was successful and the patient was discharged uneventfully. Intestinal pseudo-obstruction ought to be consideredwhen dealing with non-obstructive(adynamic) conditions of the digestive tract associated with HZ infection; since early recognition may help to avoid unnecessary surgery. | Roberto Anaya-Prado José V Pérez-Navarro Ana Corona-Nakamura Michelle M Anaya-Fernández Roberto Anaya-Fernández Marian Eliza Izaguirre-Pérez | 2018 | World Journal of Clinical Cases2018，6，6： | 4 |
| 10 | Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer显示文摘 | Uzma Asghar Eliza Hawkes David Cunningham | 2010 | Clinical Colorectal Cancer2010，，5： | 2 |
| 11 | Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons显示文摘Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty percent.For patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous techniques.Goals of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage disease.This review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative therapies.Attention is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC. | Mina S Makary Stuart Ramsell Eric Miller Eliza W Beal Joshua D Dowell | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 12 | 葡萄膜炎患者白内障手术的治疗显示文摘葡萄膜炎患者的白内障手术具有多重挑战,其中炎症的控制是最重要的。长期的眼内炎症(葡萄膜炎)导致白内障的形成,长期使用类固醇也是如此。在治疗葡萄膜炎并发性白内障方面存在多种手术挑战,如虹膜后粘连、虹膜萎缩、小瞳孔、瞳孔膜、纤维性前囊、成熟白内障、角膜新生血管和悬韧带无力。 | Aravind Harapriya Eliza Anthony 郑楠 | 2019 | 实用防盲技术2019，14，2： | 2 |
| 13 | Functional grouping and cortical–subcortical interactions in emotion: A meta-analysis of neuroimaging studies显示文摘 | Hedy Kober Lisa Feldman Barrett Josh Joseph Eliza Bliss-Moreau Kristen Lindquist Tor D. Wager | 2008 | Neuroimage2008，，2： | 2 |
| 14 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 15 | Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats显示文摘 | J. Eliza P. Daisy S. Ignacimuthu V. Duraipandiyan | 2009 | Chemico-Biological Interactions2009，，1： | 2 |
| 16 | Immunophenotype of peripheral blood natural killer cells and IL ‐10 serum levels in relation to Helicobacter pylori status显示文摘 | Karolina Rudnicka Agnieszka Matusiak Eliza Miszczyk Wies?awa Rudnicka Micha? Tenderenda Magdalena Chmiela | 2013 | APMIS2013，，9： | 2 |
| 17 | Read it and believe it: How metaphor constructs ideology in news discourse. A case study显示文摘 | Eliza Kitis Michalis Milapides | 1997 | Journal of Pragmatics1997，，5： | 1 |
| 18 | Unveiling the mechanisms of cell fusion 显示文摘 | Eliza Bethhchen Eriendson | 2005 | Science2005，308，： | 1 |
| 19 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 20 | Properties of trehalase from different organs of alfalfa, Medicago sativa 显示文摘 | Barbara W M Eliza M Wanda M | 2005 | Acta Physio Plant2005，27，1： | 1 |
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