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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 3 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 4 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 5 | An attempt to close the daytime surface energy 显示文摘 | Matthias M Raymond L D Elizabeth P | 2010 | Boundary-Layer Meteorology2010，136，2： | 1 |
| 6 | Aluminum accumulationand its relationship with mineral plant nutrients in 12 pteridophytesfrom Venezuela 显示文摘 | Elizabeth O Eder P Eunice M | 2009 | Environ Exp Bot2009，65，13： | 1 |
| 7 | The Receptor for Urokinase-type Fibroblasts显示文摘 | ELIZABETH M VERTMAN G CARBON W P | 2004 | J Biol Chem2004，279，2： | 1 |
| 8 | A Cell Line (HEW) from Embryos of Haddock(Melanogram- mus aeglefinius) and Its Capacity to Tolerate Environ- mental Extremes显示文摘 | BRYSON S P ELIZABETH M JOYCE D | 2006 | Mar Biotechnol2006，，8： | 1 |
| 9 | Real-world environment models for mobile network evaluation 显示文摘 | Amit P Jardosh Elizabeth M Beldlng-Royer | 2005 | IEEE Journal on Selected Areas in Communications2005，23，3： | 1 |
| 10 | Scalability study of the ad hoc on - demand distance vector routing protocol 显示文摘 | Sung Ju Lee Elizabeth M R Charles E P | 2003 | Wiley International Journal of Network Management2003，13，2： | 1 |
| 11 | Effect of heat treatments on Canola Press Oils显示文摘 | Elizabeth M P Vivekenand S V Frank W S | 1991 | Journal of the American Oil Chemists'' Society1991，68，6： | 1 |
| 12 | Treatment of swine manure effluent using freshwater algae : Production, nutrient recovery, and elemental composition of algal biomass at four effluent loading rates 显示文摘 | Elizabeth K W Carolina P Walter W M | 2006 | Journal of Applied Phyeology2006，18，1： | 1 |
| 13 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 14 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，： | 1 |
| 15 | Reflectance and transmittance spectroscopy applied to detecting fumonisin in single corn kernels infected with Fusarium verticillioides显示文摘 | Floyd E D Tom C P Elizabeth B M | 2002 | Cereal Chemistry2002，79，2： | 1 |
| 16 | Recycling of manure nutrients:use of algal biomass from dairy manure treatment as a slow release fertilizer显示文摘 | Walter M Elizabeth K W Carolins P | 2005 | Bioresource Technology2005，96，4： | 1 |
| 17 | Dissemination of entomopathogenic fungi using Busseola fusca male as vector显示文摘 | Nguya K M Elizabeth O Ahuyab P | 2011 | Biological Control2011，58，： | 1 |
| 18 | Real-world environment models for mobile network evaluation 显示文摘 | Amit P Jardosh Elizabeth M | 2005 | IEEE Journal on selected Areas In Communications2005，3，23： | 1 |
| 19 | Identification andcharacterization of class 1 integron resistance gene cassettes amongSalmonella strains isolated from imported seafood显示文摘 | Ashraf A K Elizabeth P Nawaz M S | 2009 | Appliedand Environmental Microbiology2009，75，4： | 1 |
| 20 | Effect of heat treatments on Canola Press Oils显示文摘 | Elizabeth M P Vivekenand S V Frank W S | 1991 | Journal of the American Oil Chemists'' Society1991，68，6： | 1 |
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