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| 1 | Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells显示文摘 | A. M. Madec R. Mallone G. Afonso E. Abou Mrad A. Mesnier A. Eljaafari C. Thivolet | 2009 | Diabetologia2009，，7： | 3 |
| 2 | Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cellexpansion and activation through caspase 1 activation:contribution to the chronicity of rheumatoid arthritis显示文摘 | Eljaafari A Tartelin ML Aissaoui H | | 0，，07： | 1 |
| 3 | Effects of Interleukin-17A on Osteogenie Differentiation of Isolated Human Mesenchymal Stem Cells显示文摘 | Osta B Lavocat F Eljaafari A | 2014 | Front Immunol2014，2，5： | 1 |
| 4 | Distinct subsets of dendritic ceils resembling dermal DCs can be generated in vitro from monocytes in the presence of different serum supplements显示文摘 | Duperriers K Eljaafari A Dezutter-Dambuyant C | | 0，，1： | 1 |
| 5 | Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements显示文摘 | Duperrier K Eljaafari A Dezutter-Dambuyant C | 2000 | Immunol Methods2000，238，12： | 1 |
| 6 | Isolation of regulatory T cells in the skin of a human hand-allograft,up to six years posttransplantation显示文摘 | Eljaafari A Badet L Kanitakis J | | 0，，12： | 1 |
| 7 | Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cellexpansion and activation through caspase 1 activation:contribution to the chronicity of rheumatoid arthritis显示文摘 | Eljaafari A Tartelin ML Aissaoui H | | 0，，07： | 1 |
| 8 | Bone marrow–derived and synovium‐derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis显示文摘 | Assia Eljaafari Marie‐Laure Tartelin Hanaa Aissaoui Guillaume Chevrel Bilal Osta Fabien Lavocat Pierre Miossec | 2012 | Arthritis & Rheumatism2012，，7： | 1 |
| 9 | Generation of stable monocyte-derived dendritic cells in the presence of high concentrations of homologous or autologous serum:influence of extra-cellular pH显示文摘 | Eljaafari A Duperrier K Mazet S | | 0，，10： | 1 |
| 10 | Bone marrow-derived and synovium- derived mesenchymal cells promote Thl 7 cell expansion and activation through cas- pasel activation: contribution to the chro- nicity of rheumatoid arthritis显示文摘 | Eljaafari A Tartelin ML Aissaoui H | 2012 | Arthritis Rheum2012，64，7： | 1 |
| 11 | Differentiation of hMSC in Micromass Culture显示文摘 | Natalia De ISIA Céline HUSELSTEIN Luc MARCHAL Marie-Nathalie SARDA-KOLOPP Jing-Ping OU YANG Jean-Franois STOLTZ Assia ELJAAFARI | 2005 | 生物医学工程学杂志2005，22，S1： | 0 |
| 12 | Mesenchymal Stem Cells Inhibit Dendritic Cell Maturation and Their Allosti mulatory Capacity显示文摘 | Sophie PACZESNY Veronique LATGER CANNARD Luc MARCHAL Bernard FOLLIGUET Jean-Franéois STOLTZ Assia ELJAAFARI | 2005 | 生物医学工程学杂志2005，22，S1： | 0 |
| 13 | Involvement of glycated albumin in adipose-derived-stem cellmediated interleukin 17 secreting T helper cell activation显示文摘BACKGROUND Advanced glycation end products(AGE)are a marker of various diseases including diabetes,in which they participate to vascular damages such as retinopathy,nephropathy and coronaropathy.Besides those vascular complications,AGE are involved in altered metabolism in many tissues,including adipose tissue(AT)where they contribute to reduced glucose uptake and attenuation of insulin sensitivity.AGE are known to contribute to type 1 diabetes(T1D)through promotion of interleukin(IL)-17 secreting T helper(Th17)cells.AIM To investigate whether lean adipose-derived stem cells(ASC)could be able to induce IL-17A secretion,with the help of AGE.METHODS As we have recently demonstrated that ASC are involved in Th17 cell promotion when they are harvested from obese AT,we used the same co-culture model to measure the impact of glycated human serum albumin(G-HSA)on human lean ASC interacting with blood mononuclear cells.IL-17A and pro-inflammatory cytokine secretion were measured by ELISA.Receptor of AGE(RAGE)together with intercellular adhesion molecule 1(ICAM-1),human leukocyte Antigen(HLA)-DR,cluster of differentiation(CD)41,and CD62P surface expressions were measured by cytofluorometry.Anti-RAGE specific monoclonal antibody was added to co-cultures in order to evaluate the role of RAGE in IL-17A production.RESULTS Results showed that whereas 1%G-HSA only weakly potentiated the production of IL-17A by T cells interacting with ASC harvested from obese subjects,it markedly increased IL-17A,but also interferon gamma and tumor necrosis factor alpha production in the presence of ASC harvested from lean individuals.This was associated with increased expression of RAGE and HLA-DR molecule by cocultured cells.Moreover,RAGE blockade experiments demonstrated RAGE specific involvement in lean ASC-mediated Th-17 cell activation.Finally,platelet aggregation and ICAM-1,which are known to be induced by AGE,were not involved in these processes.CONCLUSION Thus,our results demonstrated that G-HSA potentiated lean ASC-mediated IL-17A production in AT,suggesting a new mechanism by which AGE could contribute to T1D pathophysiology. | Julien Pestel Maud Robert Sara Corbin Hubert Vidal Assia Eljaafari | 2020 | World Journal of Stem Cells2020，12，7： | 0 |
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