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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Rapid evaluation and optimization of recombinant protein production using GFP tagging显示文摘 | Elke R Grit S Kim S | 2001 | Protein Expression and Purification2001，21，1： | 1 |
| 3 | Effects of high pressure and temperature on buckwheat starch characteristics 显示文摘 | Katleen J R Vallons'Elke K Arendt | 2009 | Eur Food Res Technol2009，230，2： | 1 |
| 4 | Immunohistoehemical localllization of the IAP protein Survivin in bladder mucosa and transitional cell carcinoma 显示文摘 | Lehner R Lucia MS Elke A | 2002 | AIMM2002，10，： | 1 |
| 5 | Cerebral gliomas: diffusional kurtosis imaging analysis of microstructural difference 显示文摘 | Peter R Elke H Kea F | 2010 | Radiology2010，254，6： | 1 |
| 6 | Principles and phenomena of bioengineering with glass-ceramics for dental restoration 显示文摘 | Wolfram H Volker R Elke A | 2007 | Journal of the European Ceramics Society2007，27，： | 1 |
| 7 | Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer显示文摘 | Annette Eyking Birgit Ey Michael Rünzi Andres I. Roig Henning Reis Kurt W. Schmid Guido Gerken Daniel K. Podolsky Elke Cario | 2011 | Gastroenterology2011，，6： | 1 |
| 8 | The effect of quercetin on the mRNA expression of different antioxidant enzymes in hepatoma cells显示文摘 | Elke R?hrdanz Achim Bittner Quynh-Hoa Tran-Thi Regine Kahl | 2003 | Archives of Toxicology2003，，9： | 1 |
| 9 | Retention,HIV risk and illicit drug use during treatment:methadone dose and visit frequency显示文摘 | Rhoades HM Creson D Elk R | 1998 | Am J Public Health1998，88，： | 1 |
| 10 | Association between insulin secretion,insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies显示文摘 | Ruchat S M Elks C E Loos R J Vohl M C Weisnagel S J Rankinen T | 2009 | Acta Diabetol2009，46，： | 1 |
| 11 | Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1显示文摘 | Oostvogels R Minnema MC van Elk M | 2013 | Leukemia2013，27，： | 1 |
| 12 | Parallel multisource view main- tenance显示文摘 | Zhang X Ding L L Elke A R | 2004 | The VLDB Journal2004，13，1： | 1 |
| 13 | β-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations显示文摘 | Elke N Angelina B R Gunilla O | 2006 | The American Journal of Clinical Nutrition2006，83，3： | 1 |
| 14 | Gizewski Matthias Maschke Copper deficiency myelopathy induced by repetitive parenteral zine supplemen-tation during chronic haemodialysis显示文摘 | Yaldizli Uwe Johansson Elke R | 2006 | J Neurol2006，253，： | 1 |
| 15 | Childhood obesity显示文摘 | Lakshman R Elks C E Ong K K | 2012 | Circulation2012，126，14： | 1 |
| 16 | Immunobistocbemleal localization of the IAP protein survivin in bladder mucosa and transitional cell carcinoma 显示文摘 | LEHNER R LUCIA M S ELKE A | 2002 | Appl Immunohlstochem Mol Morphol2002，10，2： | 1 |
| 17 | Microstructure, fundamental rheology and baking characteristics of batters and breads from different gluten-free flours treated with a microbial transglutaminase显示文摘 | STEFANO R FABIO D B ELKE K A | 2008 | J Cereal Sci2008，48，1： | 1 |
| 18 | Childhood obesity显示文摘 | Lakshman R Elks CE Ong KK | 2012 | Cir- culation2012，126，14： | 1 |
| 19 | Current status of palliative care-clinical im- plementation, education and research CA 显示文摘 | Grant M Elk R Ferrell BC | 2010 | Cancer J Clin2010，59，5： | 1 |
| 20 | Bioactivity-Guided Isola- tion of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora Roots As a PTP 1B Inhibitor 显示文摘 | Renate R Dirk S Elke H | 2010 | Jour- nal of Natural Products2010，73，： | 1 |
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