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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Hemivertebra excision in children via simultaneous anterior and posterior exposures 显示文摘 | Hedequist D J Hall JE Emans JB | 2005 | J Pediatr Orthop2005，25，： | 1 |
| 3 | Patterns of interdependence in work teams: A two-level investigation of the relations with job and team satisfaction 显示文摘 | Van Der Vegt G S Emans B J M Van De Vliert E | 2001 | Personnel Psychology2001，54，1： | 1 |
| 4 | Seasonal distribution of dissolved pesticides and polynuclear aromatic hydrocarbons in the Humber Estuary and Humber coastal zone显示文摘 | Zhou J L Fil Eman T W Evans S | 1996 | Mar Poll Bull1996，32，： | 1 |
| 5 | Three rod technique fa- cilitates hemivertebra wedge excision in young children through a posterior only approach 显示文摘 | Hedequist D Emans J Praetor M | 2009 | Spine2009，34，： | 1 |
| 6 | Congenital scoliosis:a review and update显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，1： | 1 |
| 7 | The correlation of preoperative three-dimensional computed tomography reconstructions with operative findings in congenital scoliosis显示文摘 | Hedequist D J Emans JB | 2003 | Spine2003，28，22： | 1 |
| 8 | Congenital scoliosis显示文摘 | Hedequist D Emans J | 2004 | J Am Acad Orthop Surg2004，12，4： | 1 |
| 9 | Congenital scoliosis:a review and update显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 10 | Hemivertebra excision in children via simultaneous anterior and posterior exposures 显示文摘 | Hedequist D J Hall J E Emans J B | 2005 | J Pediatr Orthop2005，25，1： | 1 |
| 11 | Patterns of In- terdependence in Work Teams : A Two - level Investi- gation of the Relations with Job and Team Satisfaction 显示文摘 | Vegt G S Emans B J Van Vliert E | 2001 | Personnel Psychology2001，54，1： | 1 |
| 12 | LEMAK, A meta-analysis of the effect of TQM on competitive advantage 显示文摘 | EMAN EL SHENAWY TIM BAKER & DAVID J | 2007 | International Journal of Quality & Reliability Management2007，24，5： | 1 |
| 13 | Congenital scoliosis: a review and update 显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 14 | Ceurovascular injury and clisplacement in type Ⅲ humeral supracondylar fractures显示文摘 | Campbell C C Waters P M Emans J B | 1995 | J Pediatr Orthop1995，15，1： | 1 |
| 15 | Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest显示文摘 | CHEON G E IVORY K DOL EMAN J | 2004 | Carcinogenesis2004，25，10： | 1 |
| 16 | Congenital scoliesis: a review and update显示文摘 | Hedquist D Emans J | 2007 | Pediatr Orthop2007，27，1： | 1 |
| 17 | Fusionless instrumentation systems for congenital scoliosis:expandable spinal rods and vertical expandable prosthetic titanium rib in the management of congenital spine deformities in the growing child显示文摘 | Yazici M Emans J | | 0，，1976： | 1 |
| 18 | Congenital scoliosis:a review and update 显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 19 | Autologous engineering of cartilage显示文摘 | Emans P J | | 0，，： | 1 |
| 20 | Congenital scoliosis显示文摘 | Hedequist D Emans J | 2004 | Am Acad Orthop Surg2004，12，4： | 1 |
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