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| 1 | Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation显示文摘Antibody-mediated rejection(AMR) caused by donorspecific anti-human leukocyte antigen antibodies(DSA) is widely accepted to be a risk factor for decreased graft survival after kidney transplantation. This entity also plays a pathogenic role in other solid organ transplants as it appears to be an increasingly common cause of heart graft dysfunction and an emerging issue in lung transplantation. In contrast, the liver appears relatively resistant to DSA-mediated injury. This 'immune-tolerance' liver property has been sustained by a low rate of liver graft loss in patients with preformed DSA and by the intrinsic liver characteristics that favor the absorption and elimination of DSA; however, alloantibody-mediated adverse consequences are increasingly being recognized, and several cases of acute AMR after ABO-compatible liver transplant(LT) have been reported. Furthermore, the availability of new solid-phase assays, allowing the detection of low titers of DSA and the refinement of objective diagnostic criteria for AMR in solid organ transplants and particularly in LT, have improved the recognition and management of this entity. A cost-effective strategy of DSA monitoring, avoidance of class Ⅱ human leukocyte antigen mismatching, judicious immunosuppression attached to a higher level of clinical suspicion of AMR, particularly in cases unresponsive to conventional antirejection therapy, can allow a rational approach to this threat. | Antonio Cuadrado David San Segundo Marcos López-Hoyos Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，39： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 4 | Efficiency and spatial equity impacts of high-speed rail extensions in urban areas显示文摘 | Andrés Monzón Emilio Ortega Elena López | 2013 | Cities2013，，： | 2 |
| 5 | P-Selectin Expression and Kupffer Cell Activation in Rat Acute Pancreatitis显示文摘 | Emma Folch Neus Prats Georgina Hotter Santiago López Emilio Gelpi Joan Roselló-Catafau Daniel Closa | 2000 | Digestive Diseases and Sciences2000，，8： | 2 |
| 6 | Percutaneous fixation of displaced proximal humeral fractures: Indications based on the correlation between clinical and radiographic results显示文摘 | Emilio Calvo Ignacio de Miguel Juan J. de la Cruz Néstor López-Martín | 2007 | Journal of Shoulder and Elbow Surgery2007，，6： | 2 |
| 7 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 8 | Local perspectives in the control of greenhouse gas emissions – The case of Rio de Janeiro显示文摘 | Carolina Burle Schmidt Dubeux Emilio Lèbre La Rovere | 2007 | Cities2007，，5： | 1 |
| 9 | Mutual GuaranteeInstitutions and Small Business Finance显示文摘 | Columba F Gambacorta L Emilio P | 2010 | Journal of financialstability2010，，6： | 1 |
| 10 | The quest for eco - social efficiency in biofuels production in Brazil显示文摘 | SILVIA BLAJBERG SCHAFFEL EMILIO L~BRE LA ROVERE | 2010 | Journal of Cleaner Production2010，，18： | 1 |
| 11 | Pharmacokinetic aspects of levofloxacin 500 mg once daily during sequential intravenous/oral therapy in patients with lower respiratory tract infections显示文摘 | Mario F Loris B Emilio L | 2003 | Journal of Antimicrobial Chemotherapy2003，51，： | 1 |
| 12 | Response of parasitoids Dendrosoter protuberans and Cheiropachus quadrum to attractants of Phloeotribus scarabaeoides in an olfactometer显示文摘 | Carlos L Emilio G Aranzazu P | 2000 | Journal of Chemical Ecology2000，26，3： | 1 |
| 13 | Origin of vesicle layering and double imbrication by endogenous growth in the Birkett basalt flow (Columbia river plateau)显示文摘 | George P L Walker Edgardo Canon-Tapia Emilio Herrero-Bervera | 1999 | Journal of Volcanology and Geothermal Research1999，88，： | 1 |
| 14 | Trichoderma-plant-pathogen interactions显示文摘 | Franceseo V Krishnapillai S Emilio L | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 15 | Use of EIS for the evaluation of the protective properties of coatings for metallic cultural heritage : a review显示文摘 | Emilio C Diana L David M B | 2010 | Solid State Electrochem2010，14，3： | 1 |
| 16 | Latex Agglutination Assays for Detection of Non-O157 Shiga Toxin-Producing Escherichia coli Serogroups O26, O45, O103, O111,O121, and O145[dagger]显示文摘 | Medina Marjorie B Shelver Weilin L Fratamico Pina M Fortis Laurie Tillman Glenn Narang Neelam Cray William C Esteban Emilio DebRoy Chitrita | 2012 | EN2012，，5： | 1 |
| 17 | Highly stereoselective reduction of haloketones using three new yeasts: application to the synthesis of (S)-adrenergic β-blockers related to propranolol 显示文摘 | Fernando M L Jose D C Jose L B Emilio A Jose V S | 2004 | Tetrahedron: Asymmetry2004，15，： | 1 |
| 18 | Resonant silicon accelerometers in bulk micromachining technology-an approach 显示文摘 | Burrer C Esteve J Emilio L T | 1996 | Journal of Microelectromechanical Systems1996，5，2： | 1 |
| 19 | Free-product plume distribution and recovery modeling prediction in a diesel-contaminated volcanic aquifer显示文摘 | ANTONIO H E PEDRO M S EMILIO S L | | 0，，02： | 1 |
| 20 | Ecological of the rare microbial biosphere of the Arctic Ocean 显示文摘 | Pierre E G Emilio O C David L K | 2009 | PNAS2009，106，22： | 1 |
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