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    题名 作者 年代 出处 被引量
1aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen 2016Molecular Plant2016,9,6:70
2Permian volcanisms in eastern and southeastern margins of the Jiamusi Massif, northeastern China: zircon U-Pb chronology, geochemistry and its tectonic implications显示文摘LA-ICP-MS zircon U-Pb dating and geochemical data for the Late Paleozoic volcanic rocks from eastern and southeastern margins of the Jiamusi Massif are presented to understand the regional tectonic evolution. Zircons from eight representative volcanic rocks are euhedral-subhedral in shape and dis- play striped absorption and fine-scale oscillatory growth zoning as well as high Th/U ratios (0.33―2.37), implying a magmatic origin. The dating results show that the Late Paleozoic volcanic rocks in the study area can be divided into two stages, i.e., the Early Permian (a weighted mean 206Pb/238U age of 288 Ma) and the Middle Permian volcanisms (a weighted mean 206Pb/238U age of 268 Ma). The former is com- posed mainly of basalt, basaltic-andesite, andesite and minor dacite. They are characterized by low SiO2 contents, high Mg# (0.40―0.59), enrichment in Na (Na2O/K2O = 1.26―4.25) and light rare earth elements (LREEs), relative depletion in heavy rare earth elements (HREEs) and high field strength ele- ments (HFSEs), indicating that an active continental margin setting could exist in the eastern margin of the Jiamusi Massif in the Early Permian. The latter consists mainly of rhyolite and minor dacite with high SiO2 (77.23%―77.52%), low MgO (0.11%―0.14%), enrichment in K2O (Na2O/K2O ratios < 0.80) and Rb, Th, U and depletion in Eu, Sr, P and Ti, implying a crust-derived origin. Therefore, it is proposed that the Middle Permian volcanic rocks could have formed under the collision of the Jiamusi and the Khanka Massifs.MENG En XU WenLiang YANG DeBin PEI FuPing Yu Yang Zhang XingZhou 2008Chinese Science Bulletin2008,53,8:42
3Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens.ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael 2015Biomedical and Environmental Sciences2015,28,10:24
4Risk Factors, Clinical Features and Prognosis for Subtypes of Ischemic Stroke in a Chinese Population显示文摘Ya-fu TAN Li-xuan ZHAN Xiao-hui CHEN Jian-jun QUO Chao QIN En XU 2018Current Medical Science2018,38,2:23
5Flow Ripple of Axial Piston Pump with Computational Fluid Dynamic Simulation Using Compressible Hydraulic Oil显示文摘The flow ripple, which is the source of noise in an axial piston pump, is widely studied today with the computational fluid dynamic(CFD) technology development. In the traditional CFD modeling, the fluid compressibility, which strongly influences the accuracy of the flow ripple simulation results, is often neglected. So a compressible sub-model was added with user defined function(UDF) in the CFD model to predict the flow ripple. At the same time, a test rig of flow ripple was built to study the validity of simulation. The flow ripple of pump was tested with different working parameters, including the rotation speed and the working pressure. The comparisons with experimental results show that the validity of the CFD model with compressible hydraulic oil is acceptable in analyzing the flow ripple characteristics. In this paper, the improved CFD model increases the accuracy of flow ripple rate to about one-magnitude order. Therefore, the compressible model of hydraulic oil is necessary in the flow ripple investigation of CFD simulation. The compressibility of hydraulic oil has significant effect on flow ripple, and the compression ripple takes about 88% of the total flow ripple of pump. Leakage ripple has the lowest proportion of about 4%, and geometrical ripple leakage ripple takes the remnant 8%. Besides, the influence of working parameters was investigated through the CFD simulations and experimental measurements. Comparison results show that the amplitude of flow ripple grows with the increasing of rotation speed and working pressure, and the flow ripple rate is independent of the rotation speed. However, flow ripple rate of piston pump grows with the increasing of working pressure, because the leakage ripple will increase with the pressure growing. The investigation on flow ripple of an axial piston pump using compressible hydraulic oil provides a more validity simulation model for the CFD analyzing and is beneficial to further understanding of the flow ripple characteristics in an axial piston pump.MA Ji'en XU Bing ZHANG Bin YANG Huayong 2010Chinese Journal of Mechanical Engineering2010,23,1:21
6Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase显示文摘genomic DNA 的 Cytosine methylation 控制基因表示并且维持染色体稳定性。一个特定的 DNA 序列怎么被 methyltransferase 为 methylation 指向,大部分是未知的。这里,我们证明 histone H3 跟踪缺乏离氨酸 4 (K4 ) methylation 功能作为为由到它的植物 homeodomain (哲学博士) 的绑定的 methyltransferase Dnmt3a 的 allosteric 使活跃之物。在 vitro, histone H3 肽相对地刺激了 Dnmt3a 的 methylation 活动直到 8 褶层,以一种方式与 K4 methylation 的水平相关。allosteric 规定的生物意义被在 PHD 和其变化由 H3 肽然而并非 H3 肽的绑定损害了 methylation 活动的刺激的 Dnmt3a 的催化领域的分子的建模和关键残余的鉴定表明。显著地,这些变异的 Dnmt3a 蛋白质在 DNA methylation 是几乎不活跃的当他们到 genomic 的招募指向时,什么时候在老鼠表示了胚胎的干细胞,是未改变的。我们因此为 de novo DNA methylation 建议二拍子的圆舞机制 - 染色质绑定或 DNA 有约束力的因素可能帮助的 methyltransferase 的第一招募,然后取决于在 Dnmt3a 和 histone 之间的相互作用的 allosteric 激活跟踪 - 后者可能为 methylation 活动用作一个检查点。Bin-Zhong Li Zheng Huang Qing-Yan Cui Xue-Hui Song Lin Du Albert Jeltsch Ping Chen Guohong Li En Li Guo-Liang Xu 2011Cell Research2011,21,8:17
7Robotic surgical systems in maxillofacial surgery:a review显示文摘Throughout the twenty-first century, robotic surgery has been used in multiple oral surgical procedures for the treatment of head and neck tumors and non-malignant diseases. With the assistance of robotic surgical systems, maxillofacial surgery is performed with less blood loss, fewer complications, shorter hospitalization and better cosmetic results than standard open surgery.However, the application of robotic surgery techniques to the treatment of head and neck diseases remains in an experimental stage, and the long-lasting effects on surgical morbidity, oncologic control and quality of life are yet to be established. More well-designed studies are needed before this approach can be recommended as a standard treatment paradigm. Nonetheless,robotic surgical systems will inevitably be extended to maxillofacial surgery. This article reviews the current clinical applications of robotic surgery in the head and neck region and highlights the benefits and limitations of current robotic surgical systems.Hang-Hang Liu Long-Jiang Li Bin Shi Chun-Wei Xu En Luo 2017International Journal of Oral Science2017,9,2:11
8Carrier frequency offset and impulse noise estimation for underwater acoustic orthogonal frequency division multiplexing显示文摘The carrier frequency offset(CFO)and impulse noise always affect the performance of underwater acoustic communication_systems.The CFO and impulse noise could be estimated by using the null subcarriers to cancel the effects of the two types of interference.The null subcarriers estimation methods include optimal separate estimation and joint estimation.The separate estimation firstly estimates the CFO value and then estimates the impulse noise value.However,the CFO and impulse noise always affect each other when either of them is estimated separately.The performance could be improved by using the joint estimation.The results of simulations and experiments have showed that these two optimization methods have good performance and the joint estimation has better performance than the separate estimation method.There is 3 dB performance gain at the BER value of 10^(-2)when using the joint estimation method.Thus these methods could improve the system robustness by using the CFO compensation and impulse noise suppression.SUN Haixin XU Xiaoka MA Li KUAI Xiaoyan CHENG En CHEN En 2014Chinese Journal of Acoustics2014,33,3:8
9Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance显示文摘有非小的房间肺癌症(NSCLC ) 的最对待 gefitinib 的病人将最后开发抵抗。从 LC Hemsl 的 Lysimachia capillipes (LC ) capilliposide 摘录。在 vitro 并且在 vivo 反癌症效果出现。在这研究,我们调查了在有 gefitinib 的联合的 LC capilliposide 是否能克服 NSCLC 房间的抵抗到 gefitinib 并且识别包含的发信号的小径。有 LC capilliposide 的治疗独自禁止了 NSCLC 房间线(PC-9, H460, H1975, H1299 和 PC-9-GR ) 的一块面板的生长对有在 g/mL 的范围的 IC 50 价值的 gefitinib 敏感或抵抗。在 gefitinib 抵抗的 PC-9-GR 房间(它有一个 T790M EGFR 变化) , LC capilliposide (在 IC30, i.e.1.2 g/mL ) 显著地与它的 IC50 价值提高了 gefitinib 的禁止的效果从 6.80Shi-rong ZHANG Ya-si XU Er JIN Lu-cheng ZHU Bing XIA Xu-feng CH EN Fan-zhu LI Sheng-lin MA 2017Acta Pharmacologica Sinica2017,38,1:7
10Protective effect of YHI and HHI-I against experimental acute pancreatitis in rabbits显示文摘ProtectiveefectofYHIandHHIIagainstexperimentalacutepancreatitisinrabbitsZHAOLianGen,WUXiaoXian,HANEnKun,CHENYuLing,CHENC...ZHAO Lian Gen, WU Xiao Xian, HAN En Kun, CHEN Yu Ling, CHEN Chi and XU Dong Qin 1998World Journal of Gastroenterology1998,4,3:6
11On water in nominally anhydrous minerals from mantle peridotites and magmatic rocks显示文摘Trace amount of water associated with the lattice defects of nominally anhydrous minerals(NAMs) can be measured using Fourier transform infrared spectroscopy(FTIR) and secondary ion mass spectrometry(SIMS). Lots of data on water in NAMs from different lithologies, especially mantle peridotite xenoliths, have been published. The water distribution in olivine from peridotite xenoliths often displays a diffusion profile with high water concentration in the core and low at the rim, which indicates water loss via diffusion during the ascent of host magma. On the other hand, water is homogeneously distributed in pyroxene and its concentration is typically interpreted to represent a mantle value. The water concentration of magma in equilibrium with NAM can be estimated using specific partition coefficient, from which the water content of parental magma and the mantle source can be inferred. The accuracy of this method, however, depends on the selection of appropriate partition coefficient for the system. Using hydrogen isotope compositions and H_2O/Ce ratios of mantle NAMs, water source regions can be traced and water heterogeneity can be mapped in the upper mantle. Water plays an important role in the stability of cratonic mantle. The water contents and vertical distribution patterns can be significantly different among different cratonic mantles, which may result from different geologic activities. However, the mantle-plume interaction may not necessarily result in significant change of water content in cratonic mantle. The estimation of the water content in the upper mantle is still largely based on geochemical models due to the limitations of data on water in mantle NAMs.HUI HeJiu XU YongJiang PAN Ming'En 2016Science China Earth Sciences2016,59,6:5
12STUDY ON FATIGUE DAMAGE BELOW THE FATIGUE LIMIT AND THE COAXING EFFECTS显示文摘STUDYONFATIGUEDAMAGEBELOWTHEFATIGUELIMITANDTHECOAXINGEFFECTSWUZhixue;LUWengeandXUHao1)(FushunPetroleuminstitute,Fushun113001,...WU Zhixue LU Wenge and XU Hao1)(Fushun Petroleum institute, Fushun 113001, China)2)(State Key Laboratory for Fatigue and Fracture of Materials, Institute of Metal Research, ChineseAcademy of Sciences, Shenyang 110015, China)3)(Institute of Mechanical En 1996Acta Metallurgica Sinica(English Letters)1996,9,3:5
13Melamine modified carbon felts anode with enhanced electrogenesis capacity toward microbial fuel cells显示文摘Surface electropositivity and low internal resistance are important factors to improve the anode performance in microbial fuel cells(MFCs). Nitrogen doping is an effective way for the modification of traditional carbon materials. In this work, heat treatment and melamine were used to modify carbon felts to enhance electrogenesis capacity of MFCs. The modified carbon felts were characterized using X-ray photoelectron spectroscopy(XPS), scanning electron microscope(SEM), atomic force microscopy(AFM)and malvern zeta potentiometer. Results show that the maximum power densities under heat treatment increase from 276.1 to 423.4 m W/m^2(700 °C) and 461.5 m W/m^2(1200 °C) and further increase to472.5 m W/m^2(700 °C) and 515.4 m W/m^2(1200 °C) with the co-carbonization modification of melamine.The heat treatment reduces the material resistivity, improves the zeta potential which is beneficial to microbial adsorption and electron transfer. The addition of melamine leads to the higher content of surface pyridinic and quaternary nitrogen and higher zeta potential. It is related to higher MFCs performance. Generally, the melamine modification at high temperature increases the feasibility of carbon felt as MFCs' s anode materials.Yang'en Xie Zhaokun Ma Huaihe Song Zachary A.Stoll Pei Xu 2017Journal of Energy Chemistry2017,26,1:5
14Experimental study on the laminar flame speed of hydrogen/natural gas/air mixtures显示文摘Laminar flame speeds of hydrogen/natural gas/air mixtures have been measured over a full range of fuel compositions(0-100%volumetric fraction of H_(2))and a wide range of equivalence ratio using Bunsen burner.High sensitivity scientific CCD camera is use to capture the image of laminar flame.The reaction zone area is employed to calculate the laminar flame speed.The initial temperature and pressure of fuel air mixtures are 293 K and 1 atm.The laminar flame speeds of hydrogen/air mixture and natural gas/air mixture reach their maximum values 2.933 and 0.374 m/s when equivalence ratios equal to 1.7 and 1.1,respectively.The laminar flame speeds of hydrogen/natural gas/air mixtures rise with the increase of volumetric fraction of hydrogen.Moreover,the increase in laminar flame speed as the volumetric fraction of hydrogen increases presents an exponential increasing trend versus volumetric fraction of hydrogen.Empirical formulas to calculate the laminar flame speeds of hydrogen,natural gas,and hydrogen/natural gas mixtures are also given.Using these formulas,the laminar flame speed at different hydrogen fractions and equivalence ratios can be calculated.Chen DONG Qulan ZHOU Xiaoguang ZHANG Qinxin ZHAO Tongmo XU Shi’en HUI 2010Frontiers of Chemical Science and Engineering2010,4,4:4
15Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste 2008Lancet Neurology2008,,5:4
16Rapid growth of a large-scale(600 mm aperture) KDP crystal and its optical quality显示文摘Potassium dihydrogen phosphate(KDP) single crystals are the only nonlinear crystals currently used for electro-optic switches and frequency converters in inertial confinement fusion research, due to their large dimension and exclusive physical properties. Based on the traditional solution-growth process, large bulk KDP crystals, usually with sizes up to600 × 600 mm2 so as to make a frequency doubler for the facility requirement loading highly flux of power laser, can be grown in standard Holden-type crystallizers, without spontaneous nucleation and visible defects, one to two orders of magnitude faster than by conventional methods. Pure water and KDP raw material with a few ion impurities such as Fe,Cr, and Al(less than 0.1 ppm) were used. The rapid-growth method includes extreme conditions such as temperature range from 60 to 35℃ , overcooling up to 5℃ , growth rates exceeding 10 mm/day, and crystal size up to 600 mm. The optical parameters of KDP crystals were determined. The optical properties of crystals determined indicate that they are of favorable quality for application in the facility.Guohui Li Guozong Zheng Yingkun Qi Peixiu Yin En Tang Fei Li Jing Xu Taiming Lei Xiuqin Lin Min Zhang Junye Lu Jinbo Ma Youping He Yuangen Yao 2014High Power Laser Science and Engineering2014,2,1:3
17Analyses of the long-term salinity variability in the Bohai Sea and the northern Huanghai (Yellow) Sea显示文摘Based on the comprehensive collection of the field observed salinity of the Bohai Sea (BHS) and the northern Huanghai Sea (NHS) from the 1950s to the present, the patterns of 10-years-averaged salinity at the different layers in the recent five decades (the 1950s, the 1960s, the 1970s, the 1980s and the 1990s) are obtained by the spatial-temporal interpolation technique with the scrupulous data quality control in this study. Then, by combining the spatial-temporal interpolation technique with successive correction method, the annual distributions of salinity both in the BHS and in the NHS are obtained as well. The data analyses indicate that the overall salinity in the BHS and the NHS increases from the 1960s till the present, with the increase of annual mean salinity of 0.04 psu from the 1950s, and the maximum increase rate of salinity is about 0.14 psu/a in the Bohai Bay. The high salinity tongue extended significantly from the NHS into the BHS. The intensified eastern wind field is related to the western intrusion of the NHS warm current, which probably leads to the moving forward of the high salinity water mass into the BHS. However, it is rather different from the salinity distribution characteristics between the 1950s and the 1960s. The extensive precipitation in the 1960s could lead to an increase in the discharge of the Huanghe River, which might result in the decrease of salinity in the BHS. But the salinity isoline of 32 in the NHS still extended significantly into the BHS in the 1960s. Since the 1980s, the patterns of salinity distribution have changed thoroughly. The salinity in the central area of the BHS was low, while the salinity in the Bohai Bay and the Liaodong Bay was higher than the other regions with its horizontal salinity gradient decreasing in the 1980s. The Empirical Orthogonal Function Analysis (EOF) is also conducted to study the interannual salinity variability of the BHS and the NHS. The correlation coefficient between the time coefficient series of the main mode and the Huanghe River discharge can reach-64.57%. It can be concluded that salinity variation of the BHS and the NHS has strong negative correlation with the Huanghe River discharge.YU Huaming BAO Xianwen LU Cuilan CHEN Xu'en KUANG Liang 2009Acta Oceanologica Sinica2009,28,5:3
18Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak显示文摘Background:Spermatogenesis is a cellular differentiation process that includes three major events:mitosis of spermatogonia,meiosis of spermatocytes and spermiogenesis.Steady-state spermatogenesis relies on functions of spermatogonial stem cells(SSCs).Establishing and maintaining a foundational SSC pool is essential for continued spermatogenesis in mammals.Currently,our knowledge about SSC and spermatogenesis is severely limited in domestic animals.Results:In the present study,we examined transcriptomes of testes from domestic yaks at four different stages(3,5,8 and 24 months of age)and attempted to identify genes that are associated with key developmental events of spermatogenesis.Histological analyses showed that the most advanced germ cells within seminiferous tubules of testes from 3,5,8 and 24 months old yaks were gonocytes,spermatogonia,spermatocytes and elongated spermatids,respectively.RNA-sequencing(RNA-seq)analyses revealed that 11904,4381 and 2459 genes were differentially expressed during the gonocyte to spermatogonia transition,the mitosis to meiosis transition and the meiosis to post-meiosis transition.Further analyses identified a list of candidate genes than may regulate these important cellular processes.CXCR4,a previously identified SSC niche factor in mouse,was one of the up-regulated genes in the 5 months old yak testis.Results of immunohistochemical staining confirmed that CXCR4 was exclusively expressed in gonocytes and a subpopulation of spermatogonia in the yak testis.Conclusions:Together,these findings demonstrated histological changes of postnatal testis development in the domestic yak.During development of spermatogonial lineage,meiotic and haploid germ cells are supported by dynamic transcriptional regulation of gene expression.Our transcriptomic analyses provided a list of candidate genes that potentially play crucial roles in directing the establishment of SSC and spermatogenesis in yak.Guowen Wang Yongchang Li Qilin Yang Shangrong Xu Shike Ma Rongge Yan Ruina Zhang Gongxue Jia Deqiang Ai Qi’en Yang 2019Journal of Animal Science and Biotechnology2019,10,4:3
19Dust storms in northern China during the last 500 years显示文摘The history and mechanisms of dust storms in northern China remain unclear owing to the paucity of reliable longterm,high-resolution geological records.In this study,we reconstructed the dust storm history of the last~500 years in northern China,based on sedimentary coarse fraction(>63μm)of a well-dated core from Lake Daihai,Inner Mongolia.The highresolution data reveal three intervals of frequent dust storms:AD 1520–1580,AD 1610–1720,and AD 1870–2000.The dust storm events in the Lake Daihai area were broadly synchronous with those inferred from other historical or geological records and generally occurred during cold intervals.Changes in the intensity of Siberian High and the westerlies modulated by temperature variations are the likely major factors controlling dust storm dynamics.An interesting feature is that although the intensities of dust storms have been systematically increased during the recent warming period,a clear decreasing trend within this period is evident.The recent increase in average dust storm intensity may be ascribed to an increase in particle supply resulting from a rapid increase in human activity,whereas the weakening trend was likely caused by decreases in average wind speed resulting from the recent global warming.Shuang ZHANG Hai XU Jianghu LAN Yonaton GOLDSMITH Adi TORFSTEIN Guilin ZHANG Jin ZHANG Yunping SONG Kang’en ZHOU Liangcheng TAN Sheng XU Xiaomei XU Yehouda ENZEL 2021Science China Earth Sciences2021,64,5:3
20Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang 2010Stroke2010,,2:3
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