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17篇 您的检索式：作者名="Engels HJ"

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		题名	作者	年代	出处	被引量
	1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
	2	Major Variations in Anatomical Origin of the Coronary Arteries:Angiographic Observations in 4250 Patients without Associated Congenital Heart Disease显示文摘	Engel HJ Torres C Page HL	1975	Cathet Cardiovasc Diagn1975，1，2：	1
	3	Major variations in anatomical origin of the coronary arteries: Angiographic observations in 4250 patients without associated congenital heart disease 显示文摘	Engel HJ Torres C Page HL	1975	Cardiovasc Diag1975，1，2：	1
	4	Influence of a chitosan on oral bacterial adhesion and growth in vitro显示文摘	Busscher HJ Engels E Dijkstra ILl	2008	Eur J Oral Sci2008，116，5：	1
	5	Major variations in anatomical origin of the coronary arteries:angiographic observations in 4250 patients without associated congenital heart disease显示文摘	ENGEL HJ TORRES C PAGE HL	1975	Cathet Cardiovasc Diagn1975，1，2：	1
	6	Mucosal IgA response to repeated wingate tests in females显示文摘	Fahlman MM Engels HJ Morgan AL		0，，02：	1
	7	Mucosal IgA response to repeated wingate test in females显示文摘	Fahlman MM Engels HJ Morgan AL	2001	Int J sports Med2001，22，2：	1
	8	Failure of chronic ginseng supplementation to affect work performance and energy metabolism in healthy adult females显示文摘	Engels HJ Said JM Wirth JC	1996	Nut Res1996，16，：	1
	9	Effects of low--impact, moderate- intensity exercise training with and without wrist weights on functional capacities and mood states in ol- der adults显示文摘	Engels HJ Drouin J Zhu W	1998	Gerontology1998，44，4：	1
	10	Major variations in anatomical origin of the coronary ateries:Angiographic Observations in 4250 patients without associated congenital heart disease显示文摘	Engel HJ Torres C Page HL	1975	Cardiovasc Diagn1975，1，：	1
	11	Human Y chromosome azoospermia factors (AZF) mapped to different sabregions in Yq11 显示文摘	Vogt PH Edelmann A Kirsch S Henegariu O Hirschmann p Kiesewetter F Kohn FM Schill WB Farsh S Ramos C Hartmann M Hartschuh W Meschede D Behre HM Castel A Nieseldag E Weidner W Grone HJ Jung A Engel W Haidl G	1996	Hum Mol Genet1996，5，7：	1
	12	Failure of chronic ginseng supplementation to affect work performance and energy metabolism in healthy adult fenmles显示文摘	Engels HJ Said JM Wirth JC	1996	Nut Res1996，16，：	1
	13	Major variations in anatomical origin of the coronary arteries: angiographic observations in 4 250 patients without associated congenital heart disease 显示文摘	Engel HJ Tomes C Page HL	1975	Cachet cardiovase diagn1975，1，：	1
	14	Major variations in anatomical origin of the coronary ateries:Angiographic observations in 4 250 patients without associated congenital heart disease显示文摘	Engel HJ Torres C Page HL	1975	Cardiovasc Diagn1975，1，：	1
	15	Mucosal IgA response to repeated wingate tests in females显示文摘	Fahlman MM Engels HJ Morgan AL	2001	Int J Sports Med2001，22，2：	1
	16	Major variations in anatomical origin of the coronary ateries :Angiographic Observations in 4250 patients without associated congenital heart disease显示文摘	Engel HJ Torres C Page HL	1975	Cardiovasc Diagn1975，1，：	1
	17	Echinacea purpurea and mucosal immunity 显示文摘	Hall H Fahlman MM Engels HJ	2007	Int J Sports Med2007，28，9：	1

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