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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 4 | Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia显示文摘 | Erb K J Holloway JW Sobeck A | | 0，，： | 2 |
| 5 | A grain boundary characterization study of boron segregation and carbide precipitation in alloy 304 austenitic stainless steel 显示文摘 | Kurban M Erb U Aust K T | 2006 | Scripta Mater2006，54，： | 1 |
| 6 | Interface control for resistance to intergranular cracking 显示文摘 | Aust K T Erb U Palumbo G | 1994 | Mater Sci Eng A1994，176，12： | 1 |
| 7 | Actual land demand of Austria 1926-2000:avariation on ecological footprint assessments显示文摘 | Erb K H | 2004 | Land Use Policy2004，21，3： | 1 |
| 8 | Successful verbal retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate activation显示文摘 | HEUN R FREYMANN K ERB M | 2006 | Dement Geriatr Cogn Disord2006，22，2： | 1 |
| 9 | Ecological footprint time series of Australia,the Philippines,and South Korea for 1961-1999:comparing the conventional approach to an “actual land area” approach显示文摘 | Wackernagel M Monfreda C Erb K H | 2004 | Land Use Policy2004，21，3： | 1 |
| 10 | The effect of starting nanostructure on the thermal stability of electrodeposited nanocrystalline Co 显示文摘 | HIBBARD G D AUST K T ERB U | 2006 | Acta Materialia2006，54，9： | 1 |
| 11 | How to calculate and interpret ecological footprints for long periods of time:The case of Austria 1926-1995显示文摘 | HABERL H ERB K H KRAUSMANN F | 2004 | Ecological Economics2004，21，： | 1 |
| 12 | The relationship between hardness and abrasive wear resistance of electrodeposited nanocrystalline Ni - P coatings 显示文摘 | Jeong D H Erb U Aust K T | 2003 | Scripta Materialia2003，48，： | 1 |
| 13 | Ecological foot- print time series of Austria, the Phil- ippines, and South Korea for 1961--1999: Comparing the conventional ap- proach to ' actual land area' approach显示文摘 | Wackernagel M Chad M Erb K H | 2004 | Land Use Policy2004，21，3： | 1 |
| 14 | Study of the surface modification of LiNil/3 Co1/3 Mn1/3 02 cathode material for lithium ion battery 显示文摘 | Hashema A M A Abdel-Ghanya A E Eida A E Trotti- erb J Zaghibb K Maugerc A Juliend C M | 2011 | Journal of Power Sources2011，196，20： | 1 |
| 15 | In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of interferon-γ显示文摘 | Jones T C Bienz K A Erb P | 1986 | Infect Immun1986，51，： | 1 |
| 16 | Thermal gradient gel electrophoresis analysis of bioprotection from pollutant shocks in the activated sludge microbi al community显示文摘 | Eichner C A Erb R W Timmis K N | 1999 | Applied and Environmental Micro biology1999，65，： | 1 |
| 17 | Maintenance of pregnancy in ovariectomozed cattle with progestin compounds and their effect on progestin levels in the corpus luteum显示文摘 | Johnson K R Erb R E | 1962 | J Dairy Sci1962，45，： | 1 |
| 18 | Kamenev type theorems for second order matrix differential systems显示文摘 | ERBE L H KONG Q K RUAN S G | 1993 | Proc Amer Math Soc1993，117，： | 1 |
| 19 | How to calculate and interpret ecological footprints for long periods of time:the case of Australia 1926-1995显示文摘 | Haberl H Erb K H Krausmann F | 2001 | Ecological Economics2001，38，： | 1 |
| 20 | How to Calculate and Interpret Ecological Footprints for Long Periods of Time:The Case of Austria 1926 - 1995显示文摘 | Haberl H Erb K H Krausmann F | 2001 | Ecological Economics2001，，38： | 1 |
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