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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Entrepreneurialaspirations,motivations, and their drivers显示文摘 | HESSELS J G ELD EREN M V T H U R IK R | 2008 | Small BusinessEconomics2008，31，3： | 1 |
| 3 | Evaluation of macular changes after uncomplicated phacoemul- sification surgery by optical coherence tomography显示文摘 | Perente I Utine CA Ozturker C Cakir M Kaya V Eren H | 2007 | Cur Eye Res2007，32，3： | 1 |
| 4 | Pericardiectomy for chronic constrictive tuberculous pericarditis:risks and predictors of survival显示文摘 | Bozbuga N Erentug V Eren E | 2003 | TEX Heart Inst J2003，30，3： | 1 |
| 5 | Evaluation of macular changes after uncom- plicated phacoemulsification surgery by optical coherence tomography 显示文摘 | PERENTEi UTINE cA OZTURKER C CAKIR M KAYA V EREN H | 2007 | Curt Eye Res2007，32，3： | 1 |
| 6 | Fattening performance,carcass and meat quality characteristics of Kivircik male lambs显示文摘 | G觟kdal魻 Atay O Eren V | 2012 | Tropical Animal Health Production2012，44，： | 1 |
| 7 | Pericardiectomny for chronic consrlctivc tuberculous pericarditis : risks and predictors of survival 显示文摘 | Rozbuga N Ereniug V Eren E | 2003 | Fex HeartInstl2003，30，3： | 1 |
| 8 | Pericardiectomy for chronic constrictive tubercu-louspericarditis:risks and predictors of survival显示文摘 | Bozbuga N Erentug V Eren E | 2003 | TexHear Inst J2003，30，3： | 1 |
| 9 | Fattening performance, carcass and meat quality characteristics of Kivircik male lambs 显示文摘 | Gtikdal O Atay O Eren V | 2012 | Tropical Animal Health Production2012，44，： | 1 |
| 10 | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis 显示文摘 | Tahan V Eren F Avsar E | 2007 | Dig Dis Sci2007，52，： | 1 |
| 11 | Pericardiectomny for chronic consrictive tuberculous pericarditis: risks and predictors of survival 显示文摘 | Rozbuga N Ereniug V Eren E | 2003 | Fex Heart Inst 12003，30，3： | 1 |
| 12 | Rosiglitazone attenuates liver inflam- mation in a rat model of nonalcoholic steatohePatitis显示文摘 | Tahan V Eren F Avsar E | 2007 | Digestive Dis- eases and Sciences2007，52，12： | 1 |
| 13 | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis 显示文摘 | Tahan V Eren F Avsar E | 2007 | Dig Dis Sci2007，52，12： | 1 |
| 14 | Pericardiectomy for chronic constrictive tuberculous pericarditis:risks and predictors of survival显示文摘 | Bozbuga N Erentug V Eren E | 2003 | Tex Heart Inst J2003，30，3： | 1 |
| 15 | Pericardiectomy for chronic constrictive tuberculous pericarditis: risks and predictors of survival显示文摘 | Bozbuga N Erentug V Eren E | 2003 | Tex Heart Inst J2003，30，3： | 1 |
| 16 | Pericardiectomy for chronic constrictive tuberculous pericarditis:risks and predictors of survival显示文摘 | Erentug V Eren E | 2003 | Tex heart Inst J2003，30，3： | 1 |
| 17 | Selective QCM sensor based on atrazine imprinted polymer:Its application to wastewater sample显示文摘 | Gupta V K Yola M L Eren T | 2015 | Sensors and Actuators B:Chemical2015，218，： | 1 |
| 18 | Chemoenzymaticpreparation of silybin b-glucuronides and their biological evaluation显示文摘 | Eren V Ulrichova J Kosina P | 2000 | Drug Metabolism And Disposition2000，28，12： | 1 |
| 19 | Fattening performance,carcass and meat quality characteristics of Kivircik male lambs显示文摘 | G觟kdal魻 Atay O Eren V | 2012 | Tropical Animal Health Production2012，44，7： | 1 |
| 20 | Pericardiectomy for chronic constrictive tuberculous pericarditis: Risks and predictors of survival显示文摘 | Bozbuga N Erentug V Eren E | 2003 | Tex heart Inst J2003，30，3： | 1 |
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