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| 1 | Wnt signaling and Loxl2 promote aggressive osteosarcoma显示文摘Osteosarcoma(OS)is the most frequent primary malignant bone tumor in urgent need of better therapies.Using genetically modified mouse models(GEMMs),we demonstrate that Wnt signaling promotes c-Fos-induced OS formation via the actions of the collagen-modifying enzyme Loxl2.c-Fos/AP-1 directly regulates the expression of the Wnt ligands Wnt7b and Wnt9a in OS cells through promoter binding,and Wnt7b and Wnt9a in turn promote Loxl2 expression in murine and human OS cells through the transcription factors Zeb1 and Zeb2.Concordantly,inhibition of Wnt ligand secretion by inactivating the Wnt-less(Wls)gene in osteoblasts in c-Fos GEMMs either early or in a therapeutic setting reduces Loxl2 expression and progression of OS.Wls-deficient osteosarcomas proliferate less,are less mineralized and are enriched in fibroblastic cells surrounded by collagen fibers.Importantly,Loxl2 inhibition using either the pan-Lox inhibitor BAPN or a specific inducible shRNA reduces OS cell proliferation in vitro and decreases tumor growth and lung colonization in murine and human orthotopic OS transplantation models.Finally,OS development is delayed in c-Fos GEMMs treated with BAPN or with specific Loxl2 blocking antibodies.Congruently,a strong correlation between c-FOS,LOXL2 and WNT7B/WNT9A expression is observed in human OS samples,and c-FOS/LOXL2 co-expression correlates with OS aggressiveness and decreased patient survival.Therefore,therapeutic targeting of Wnt and/or Loxl2 should be considered to potentiate the inadequate current treatments for pediatric,recurrent,and metastatic OS. | Kazuhiko Matsuoka Latifa Bakiri Lena I.Wolff Markus Linder Amanda Mikels-Vigdal Ana Patiño-García Fernando Lecanda Christine Hartmann Maria Sibilia Erwin F.Wagner | 2020 | Cell Research2020，30，10： | 5 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Simple Heuristics for Push and Pull Remanufacturing Policies 显示文摘 | Erwin A Vander Laan Ruud H Teunter | 2006 | European Journal of Operational Research2006，，175： | 1 |
| 4 | Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression显示文摘 | HELMRATH M A SHIN C E ERWIN C R | 1998 | Journal of Pediatric Surgery1998，33，7： | 1 |
| 5 | Acute pancreatitis: value and impact of CT severity index显示文摘 | Alhajeri A Erwin S | 2008 | Abdom Imaging2008，33，1： | 1 |
| 6 | Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia 显示文摘 | Lennmyr F Ericsson A C erwins P | 2003 | Acta Neurol Scand2003，108，5： | 1 |
| 7 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 8 | Posttransplantation diabetes: a systematic review of the literature显示文摘 | Montori VM Basu A Erwin PJ | 2002 | Diabetes Care2002，25，3： | 1 |
| 9 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y | 1998 | Science1998，280，： | 1 |
| 10 | Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome 显示文摘 | ZHAO J SUN B K ERWIN J A | 2008 | Science2008，322，5902： | 1 |
| 11 | Com- plete genome sequence of Pseudomonas aerugino sa PAO1, an opportunistic pathogen显示文摘 | STOVER C PHAM X ERWIN A | 2000 | Na ture2000，406，6799： | 1 |
| 12 | Autecol- ogy and the filling of ecospace: key metazoan radia- tions 显示文摘 | BAMBACH R K BUSH A M ERWIN D H | 2007 | Palaeontology2007，50，： | 1 |
| 13 | Complete genome sequence of Pseudomonas aeruginosa PAO1, an op- portunistic pathogen显示文摘 | STOVER C K PHAM X Q ERWIN A L | 2000 | Nature2000，406，6799： | 1 |
| 14 | Unique molecular characteristics of radiation-induced glioblastoma 显示文摘 | Donson A Erwin N Kleinschmidt-DeMasters BK | 2007 | J Neuropathol Exp Neuro12007，66，： | 1 |
| 15 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 16 | Impact of afterschool programs to increase physical activity-ameta- analysis 显示文摘 | Beets M W Beighle A Erwin H E | 2009 | Anerucan Journal of Preventive Medicine2009，36，6： | 1 |
| 17 | A group-IV ferromagnetic semiconductor : Mnx Ge1-x 显示文摘 | PARK Y D HANBICKI A T ERWIN S C | 2002 | Science2002，295，5555： | 1 |
| 18 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 19 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 20 | Applications of life cycle assessment to nature worksTM polylactide (PLA) production显示文摘 | Erwin T H Vink Karl R Rábago David A Glassner | 2003 | Polymer Degradation and Stability2003，80，： | 1 |
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