2篇
您的检索式：作者名="Essam Imseis"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Case of hepatocellular carcinoma in a patient with hereditary tyrosinemia in the post-newborn screening era显示文摘Hereditary tyrosinemia type 1(HT-1) is a metabolic disorder caused by a defect in tyrosine degradation. Without treatment, symptoms of hepatomegaly, renal tubular dysfunction, growth failure, neurologic crises resembling porphyrias, rickets and possible hepatocellular carcinoma can develop. The use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione and early diagnosis through newborn screening initiatives have resulted in a sharp decline in morbidity and mortality associated with this disease. We present a case report of a 7-year-old patient with HT-1 who was born prior to the addition of tyrosinemia to the newborn screening in her birth area. At her time of diagnosis, the patient had developed many of the symptoms associated with her disease, including chronic kidney disease, rickets, and myopathy that left her non-ambulatory. During her initial evaluation, she was also noted to have hepatocellular carcinoma. With cadaveric liver transplantation and nutritional support, her symptoms all either resolved or stabilized. Her case il ustrates the severity of the disease if left untreated, the need for vigilance in populations who do not routinely receive newborn screens, and the markedly improved outcomes in patients following transplant. | Essam M Imseis John S Bynon Chad Thornhill | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 2 | Review on hepatic explant pathology of pediatric intestinal transplant recipients:Is it time for an oil change?显示文摘A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition with OmegavenTM that biochemical improvement in cholestasis does not always reflect improvement in liver histology.These findings support 2 small case series that were previously published.Despite improvement and resolution of hyperbilirubinemia in all six infants,five of six infants had persistent or progressive hepatic fibrosis,while only one infant had regression of fibrosis.The study raises questions of whether there is a window of opportunity for efficacy of this preparation;also,an important question is if this omega-3 fatty acid-rich preparation is superior to newer 'blended lipids' containing olive,coconut,soy,and fish oil. | Essam Imseis J Marc Rhoads | 2015 | World Journal of Gastroenterology2015，21，17： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员