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| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats显示文摘Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular diseases.Methods:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four months.Signs of general toxicity,body temperature and weight,and water and food intake were monitored in live animals.After sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was performed.Results:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total cholesterol.Lipid peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation prevented.Conclusions:These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects. | Fidele Ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet Théophile Dimo | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 3 |
| 4 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 5 | Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats显示文摘Objective:Ipomoea batatas(L.)Lam.is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions.We assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of I.batatas leaves in a rat model of diet-induced hypercholesterolemia.Methods:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four weeks.Then,rats were treated once daily(per os)with I.batatas extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four weeks.Following treatment,animals were observed for another four weeks and then sacrificed.Aortas were excised and processed for histopathological studies,and blood glucose level and lipid profile were measured.Results:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard diet.Treatment of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic values.Conclusion:Our findings suggest that I.batatas leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine. | Fidele Ntchapda Fernand C.Tchatchouang David Miaffo Barthelemy Maidadi Lorella Vecchio Rodrigue E.Talla Christian Bonabe Paul F.Seke Etet Theophile Dimo | 2021 | Journal of Integrative Medicine2021，19，3： | 2 |
| 6 | Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system显示文摘 | Maulilio John Kipanyula Wahabu Hamisi Kimaro Faustin N. Yepnjio Yousef H. Aldebasi Mohammed Farahna Armel Herve Nwabo Kamdje Eltuhami M. Abdel-Magied Paul Faustin Seke Etet | 2013 | Cellular Signalling2013，，： | 1 |
| 7 | Validation of anticonvulsant and sedative activity of six medicinal plants显示文摘 | Bum E N Taiwe G S Nkainsa L A Moto F C O Etet P F S Hiana I R Bailabar T Rouyatou Seyni P Rakotonirina A Rakotonirina S V | 2009 | Epilepsy & Behavior2009，14，： | 1 |
| 8 | Nwabo kamdje AH Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:Key role of stromal microenvironment显示文摘 | Seke Etet PF Vecchio L | | 0，，09： | 1 |
| 9 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:key role of stromal microenvironment显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 10 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: key role of stromal microenvironment 显示文摘 | Seke Etet PF Veechio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 11 | Fourteen Days Post-Ovariectomy Estrogens Decline Is Associated with Anxiogenic Effects on Wistar Rats显示文摘 | Zemo Gamo Franklin Djiogue Sefirin Ketcha Wanda Germain Jean Magloire Seke Etet Paul Faustin Yonkeu Tatchou Floriane Gaelle Djikem Tadah Rudig Nikanor Awounfack Charline Florence Njamen Dieudonne | 2017 | Journal of Pharmacy and Pharmacology2017，5，12： | 1 |
| 12 | Interactions between bone marrow stromal microenvironment and Bchronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | | 0，，07： | 1 |
| 13 | Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | | 0，，07： | 1 |
| 14 | Interac- tions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways? 显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，7： | 1 |
| 15 | Normal hematopoiesis and hematologic malignancies: role of canonical Wnt signaling pathway and stromal microenvi- ronment显示文摘 | Seke Etet PF Vecchio L Bogne Kamga P | 2013 | Biochim Biophys Acta2013，，： | 1 |
| 16 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment显示文摘 | P.F. Seke Etet L. Vecchio A.H. Nwabo Kamdje | 2012 | Cellular Signalling2012，，9： | 1 |
| 17 | Sig- naling pathways in breast cancer:therapeutic targeting of the microenvironment显示文摘 | Nwabo Kamdje AH Seke Etet PF Vecchio L | 2014 | Cell Signal2014，26，12： | 1 |
| 18 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment显示文摘 | P.F. Seke Etet L. Vecchio A.H. Nwabo Kamdje | 2012 | Cellular Signalling2012，，9： | 1 |
| 19 | Signaling pathways bridging microbial-triggered inflammation and cancer显示文摘 | Kipanyula MJ Seke Etet PF Vecchio L | | 0，，02： | 1 |
| 20 | Normal hematopoi- esis and hematologic malignancies:role of canonical Wnt signaling pathway and stromal microenvironment显示文摘 | Etet PFS Vecchio L Kamga PB | 2013 | Bio- chim Biophys Acta2013，1835，1： | 1 |
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