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| 1 | Patulin contamination in fruit derivatives, including baby food, from the Spanish market显示文摘 | Sonia Marín Eva M. Mateo Vicente Sanchis Francisco M. Valle-Algarra Antonio J. Ramos Misericordia Jiménez | 2010 | Food Chemistry2010，，2： | 1 |
| 2 | Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy显示文摘There is no effective treatment to face Alzheimer’s disease complexity.Multitarget molecules are a good approach against the multiple physiopathological events associated with its development and progression.In this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising results.ASS234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than donepezil.Besides,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and B.Moreover,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 self-aggregation.Inquiring about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant genes.Finally,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning deficits.Here we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease. | Alejandro Romero JoséMarco-Contelles Eva Ramos | 2020 | Neural Regeneration Research2020，15，1： | 1 |
| 3 | Can a place of origin of the main cystic fibrosis mutations be identified显示文摘 | Eva Mateu Francesc C Ramos MD | 2002 | Am Hum Genet2002，70，1： | 1 |
| 4 | Toxicity induced by chemical warfare agents: Insights on the protective role of melatonin显示文摘 | René Pita José Marco-Contelles Eva Ramos Javier del Pino Alejandro Romero | 2013 | Chemico-Biological Interactions2013，，2： | 1 |
| 5 | Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis显示文摘Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem cells.Neural stem cells can generate new neuronal populations through proliferation,migration,and differentiation.This neurogenic potential may be a relevant factor to fight neurodegeneration and aging.In the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis.The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules.Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis.We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin. | Alejandro Romero JoséÁngel Morales-García Eva Ramos | 2023 | Neural Regeneration Research2023，18，3： | 1 |
| 6 | Composition of goat and cow milk produced under similar conditions and analyzed by identical methodology显示文摘 | Laura Sanz Ceballos Eva Ramos Morales | | 0，，04： | 1 |
| 7 | Confounding response of macrofauna from a confluence of impacts: brine and sewage pollution显示文摘Throughout the shores of the world,a confluence of different sources of pollution is common,e.g.,through outlets releasing brine,industrial,and domestic sewage.In this study,we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of subtidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria(Canary Islands,NE Atlantic Ocean).Samples were collected in two surveys(May 2008 and January 2009)at three distances(0,15,and30 m)away from the discharge point.Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys.In May 2008,lower abundances were observed at0 m(53.89±46.82 ind.)than at 15 m(120±91.7 ind.)and 30 m(283.89±189.33 ind.)away from the disposal point.In January 2009,however,higher abundances were observed at 0 m(131.33±58.69 ind.)than at 30 m(100±24.44 ind.)and 15 m(84.78±58.39 ind.)away from the disposal point.Significant differences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys.The effect of proximity from the disposal point was confounded by changes in sedimentary composition between surveys,which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point.As a result,confounding drivers of macrofaunal assemblage structure,here,changes in sediment composition,accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage. | Rodrigo Riera Fernando Tuya Myriam Rodríguez óscar Monterroso Eva Ramos | 2013 | Acta Oceanologica Sinica2013，32，10： | 0 |
| 8 | Macrofaunal communities of threatened subtidal maёrl seabeds on Tenerife (Canary Islands, north-east Atlantic Ocean) in summer显示文摘This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of ma¨erl beds from the Canary Islands. Ma¨erl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types (Cymodocea, Caulerpa, sabellid field, garden eel and ma¨erl beds). Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables (granulometry, organic matter, nitrogen and phosphates) and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on ma¨erl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale. | Rodrigo Riera Juan Domingo Delgado Myriam Rodríguez Óscar Monterroso Eva Ramos | 2012 | Acta Oceanologica Sinica2012，31，1： | 0 |
| 9 | Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?显示文摘Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo(NE Tenerife). Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages. | Rodrigo Riera Oscar Pérez Myriam Rodríguez Eva Ramos óscar Monterroso | 2014 | Acta Oceanologica Sinica2014，33，4： | 0 |
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