| 1 | 炎性因子引发的早产儿呼吸窘迫综合征与早期心室周围/心室内出血有关显示文摘Objective: To investigate whether or not peri/intraventricularhemorrhages (PIVHs) occurring in the first 12 hours of life (early PIVHs) are related to respiratory distress syndrome(RDS)-associated inflammatory factors in contrast to PIVHs developing after 12 hours of life (late PIVHs). Study design:Blood samples obtained at 0 to 12 hours, 48 to 72 hours, and 168 hours of life were evaluated for determination of the proinflammatory cytokines interleukin (IL)-8 and IL-6, tumor necrosis factor (TNF)-α, and malondialdehyde (MDA) as measures of lipid peroxidation. Simultaneously, cranial ultrasonography was performed in 114 neonates under 32 weeks gestational age. Results: Out of the total study group of 114 neonates, 67(59%) had RDS. Early PIVHs occurred in 16 neonates, 14 ofwhom (88%) had RDS. Late PIVHs occurred in 12 neonates.Neonates with RDS had higher IL-8 and IL-6 levels at 0 to 12 hours (P < 0.0001; < 0.0001) and at 48 to 72 hours (P < 0.001;P< 0.01) than those without RDS. Neonates with early PIVH had higher IL-8 (P< 0.02), IL-6 (P< 0.02), and MDA(P<0.01) levels at 0 to 12 hours than those with late PIVH or no PIVHs. Those with early PIVHs had higher IL-8 levels at 48 to 72 hours than those without PIVHs (P < 0.02). Multiple linear regression revealed an association between RDS/early PIVHs and IL-8, IL-6,and MDA levels. Conclusions: An RDS-associated increase inproinflammatory cytokine and MDA levels was associated with early PIVHs, but not with late PIVHs, suggesting a different etiopathogenesis in early versus late PIVHs. | Krediet T.G Kavelaars A Vreman H.J F.van Bel 贺莉 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，11： | 0 |
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