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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | The functional complex network approach to foster forest resilience to global changes显示文摘Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved. | Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann | 2019 | Forest Ecosystems2019，6，3： | 2 |
| 3 | Influence of hydrolysis degree on the functional properties of salmon byproducts hydrolysates 显示文摘 | GBOGOURI G A LINDER M FANNI J | 2004 | J Food Sci2004，69，： | 1 |
| 4 | Solution structures and model membrane interactions of lactoferrampin, anantimicrobial pep- tide derived from bovine lactoferrin 显示文摘 | Evan F Haney Fanny Lau Hans J Vogel | 2007 | Biochimica et Biophysica Acta2007，1768，： | 1 |
| 5 | Influence of hydrolysis degree on the functional properties of salmon byproducts hydrolysates 显示文摘 | Gbogouri G A Linder M Fanni J | 2004 | Journal of Food Science2004，69，8： | 1 |
| 6 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 7 | Biodegradable nanoparticles-from sustained release formulations to improved site specific drug delivery显示文摘 | Jean-CL Eric A Fanny D J | 1996 | J Controlled Release1996，39，： | 1 |
| 8 | Effect of heating boundary conditions on pool boiling experiments 显示文摘 | DARABI J OHADI M M FANNI M A | 1999 | HVAC&R Research1999，5，4： | 1 |
| 9 | Influence of hydrolysis degree on the functional properties of salmon byproduct hydrolysates 显示文摘 | GBOGOURI G A LINDER M FANNI J | 2004 | J Food Sci2004，69，： | 1 |
| 10 | Influence of hydroly- sis degree on the functional properties of salmon by product hy- drolysates显示文摘 | Gbogouri G A Linder M Fanni J | 2004 | Journal of Food Science2004，69，8： | 1 |
| 11 | Protein Recovery From Veal Bones by Enzymatic Hydrolysis 显示文摘 | Linder M Fanni J Parmentier M | 1995 | J of Food Sci1995，60，5： | 1 |
| 12 | Influence of solvent , matrix dielectric properties , and applied power on the liquid - phase microwave - assisted processes ( MAP ? ) 1 extraetionof ginger ( Zingiber offieinale) 显示文摘 | Maria J Alfaroa Jacqueline M R Belanger Fanny C Padillab | 2003 | Food Research International2003，36，5： | 1 |
| 13 | Influence of Hydrolysis Degree on the Functional Properties of Salm- on Byproducts Hydrolysates显示文摘 | GBOGOURI G A LINDER M FANNI J | 2004 | Journal of food science2004，69，8： | 1 |
| 14 | Response surface optimization of lipase-catalysed esterification of glycerol and n-3 polyunsaturated fatty acids from salmon oil 显示文摘 | Linder M N Kochanowski J Fanni | 2005 | Process Biochemistry2005，40，： | 1 |
| 15 | Proteolytic extraction of salmonoil and PUFA concentration by lipases显示文摘 | LINDER M FANNI J PARMENTIER M | 2005 | Marine Biotechnology2005，15，： | 1 |
| 16 | Protein recovery from veal bones by enzymatic hydrolysis 显示文摘 | Linder M Fanni J Parmentier M | 1995 | Journal of Food Science1995，60，9： | 1 |
| 17 | Proteolytic extraction of salmon oil and PUFA concentration by lipases显示文摘 | LINDER M FANNI J PARMENTIER M | 2005 | Marine Biotechnology2005，7，1： | 1 |
| 18 | Response surface optimisation of lipase - catalysed esterification of glycerol and n - 3 polyunsaturated fatty acids from salmon oil 显示文摘 | LINDER M KOCHANOWSKI N FANNI J | 2005 | Process Biochem2005，40，： | 1 |
| 19 | Analysis oflipids extracted t~om salmon (Salmo salar) heads by commercial proteolytic enzymes显示文摘 | GBOGOURI G A LINDER M FANNI J | 2006 | European Journal of Lipid Science and Technology2006，，108： | 1 |
| 20 | Characterisation of the lipid fractions obtained by proteolitic and chemical extractions from rainbow trout (Oncorhynchus mykiss) roe显示文摘 | AL-SAYED-MAHMOUD K LINDER M FANNI J | 2008 | Process Biochemistry2008，，43： | 1 |
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