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| 1 | Autoimmune gastritis:Pathologist's viewpoint显示文摘Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling. | Irene Coati Matteo Fassan Fabio Farinati David Y Graham Robert M Genta Massimo Rugge | 2015 | World Journal of Gastroenterology2015，21，42： | 8 |
| 2 | miRNAs in precancerous lesions of the gastrointestinal tract显示文摘In spite of the well-established understanding of the phenotypic lesions occurring in the shift from native epithelia to invasive (adeno) carcinoma, the molecular typing of the precancerous changes in the gastrointestinal tract remains unreliable. In recent years, no biomarkers have aroused as much interest as the miRNAs,a class of non-coding RNA molecules that function as endogenous silencers of numerous target genes. Aberrant miRNA expression is a hallmark of human disease,including cancer. Unlike most mRNAs, miRNAs are both long-living in vivo and very stable in vitro . Such characteristics allow their testing in paraffin-embedded tissue samples, which is essential in the biological profiling of small (phenotypically characterized) preneoplastic lesions of the gastrointestinal tract (as well as in other fields of human pathology). The upcoming challenge lies in the reliable identification of disease-specific targets of dysregulated miRNAs, to enable miRNA testing in the clinical management of the secondary prevention of gastrointestinal cancer. | Matteo Fassan Carlo M Croce Massimo Rugge | 2011 | World Journal of Gastroenterology2011，17，48： | 7 |
| 3 | Programmed cell death 4 protein in esophageal cancer显示文摘 | Fassan M Cagol M Pennelli G | 2010 | Oncol Rep2010，24，1： | 1 |
| 4 | The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesis显示文摘 | Fassan M Pizzi M Realdon S | 2013 | Human pathology2013，44，9： | 1 |
| 5 | The Reliability of Endoscopic Biopsies in Assessing Her-2 Status in Gastric and Gastroesophage- al Junction Callcer: A Study Comparing Biopsies with Surgical Sam- ples显示文摘 | Grillo F Fassan M Ceccaroli C | 2013 | Transl Oncol2013，6，1： | 1 |
| 6 | MicroRNA expression profiling of male breast cancer显示文摘 | Fassan M Baffa R Palazzo JP | 2009 | Breast Cancer Res2009，11，4： | 1 |
| 7 | Programmed cell death 4 ( PDCD4 ) expression during muhistep Barrett' s carcinogenesis显示文摘 | Fassan M Pizzi M Battaqlia G | 2011 | J Clin Pathol2011，，3： | 1 |
| 8 | Programmed cell death 4 (PD CD4) expression during multistep Barrett's eareinogenesis显示文摘 | Fassan M Pizzi M Battaqlia G | 2011 | J Clin Pathol2011，64，3： | 1 |
| 9 | Classification of non-small cell lung carcinoma in transthoracic needle specimens using microRNA expression profiling 显示文摘 | FASSINA A CAPPELLESSO R FASSAN M | 2011 | Chest2011，140，5： | 1 |
| 10 | HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response显示文摘 | Codolo G Fassan M Munari F | 2012 | Cancer Immunology Immunotherapy:CII2012，61，1： | 1 |
| 11 | PDCD4 nuclear loss inversely correlates with miR-2 l levels in colon carci- nogenesis显示文摘 | Fassan M Pizzi M Giacomelli L | 2011 | Virchows Arch2011，458，4： | 1 |
| 12 | MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary rela- tionships with RET status and outcome 显示文摘 | Mian C Pennelli G Fassan M | 2012 | Thyroid2012，9，9： | 1 |
| 13 | Clinical application of microRNA testing in neuroendocrine tumors of the gastrointesti- nal tract 显示文摘 | Vicentini C Fassan M D'Angelo E | 2014 | Molecules2014，19，2： | 1 |
| 14 | MicroRNA profiles in familial and sporadic medullary thyroid carcinoma:preliminary relationships with RET status and outcome显示文摘 | Mian C Pennelli G Fassan M | | 0，，： | 1 |
| 15 | HER-2 status in gastroesophageal cancer:a tissue microarray study of 1040 cases显示文摘 | Cappellesso R Fassan M Hanspeter E | 2015 | Human Pathol2015，46，5： | 1 |
| 16 | B-cell malignancies in micl'oRNA Emu-miR-17 ~ 92 transgenic mice 显示文摘 | Sandhu S K Fassan M Volinia S | 2013 | Proc Natl Acad Sci USA2013，110，18： | 1 |
| 17 | Classification of non-small cell lung carcinoma in transthoracic needle specimens using micmRNA expression profiling 显示文摘 | Fassina A Cappellesso R Fassan M | 2011 | Chest2011，140，5： | 1 |
| 18 | B-cell malignancies in microRNA Emu-miR-17~92 transgenic mice显示文摘 | Sandhu SK Fassan M Volinia S | 2013 | Proc Natl Acad Sci U S A2013，110，18： | 1 |
| 19 | MicroRNA expression profi- ling in human B arrett's carcinogenesis 显示文摘 | Fassan M Volinia S Palatini J | 2011 | Int J Cancer2011，129，7： | 1 |
| 20 | Clinical application ofmicroRNA testing in neuroendocrine tumors of the gastrointestinal tract 显示文摘 | Vicentini C Fassan M D'Angelo E | 2014 | Molecules2014，19，2： | 1 |
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