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125篇 您的检索式:作者名="FAZIO E"
    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2Simplified generation of all mechanical assembly sequence显示文摘De Fazio T L Whitney D E 1987IEEE Journal of Robotics and Automation1987,3,64:1
3Screening-photovoltaic bright solitons in lithium niobate and associated single-mode waveguides显示文摘FAZIO E RENZI F RINALDI R 2004Applied Physics Letters2004,85,12:1
4Screening-photovoltaic bright solitons in lithium niobate and associated single-mode waveguides显示文摘FAZIO E RENZI F 0,,12:1
5Hepatocellular carcinoma in Italian patients with cirrhosis显示文摘Colombo M de Franchis R Del Ninno E Sangiovanni A De Fazio C Tommasini M New England Journal of Medicine0,,:1
6Development and characterization of PCR markers in cucumber显示文摘FAZIO G STAUB J E CHUNG S M 2002Journal of the American Soci- ety for Horticulture Science2002,127,4:1
7Simplified generation of all mechanical assembly sequences显示文摘Fazio de T L Whitney D E 1995IEEE Journal of Robotics and Automation1995,3,6:1
8A 500 MW, 1 μs pulse length high current relative klystron显示文摘Fazio M V Haynes W B Carlsten B E 1994IEEE1994,22,5:1
9Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation 显示文摘LINTON M E ATKINSON J B FAZIO S 1995Science1995,267,:1
10Effect of long-distance mad transport on thyroid and adrenal function and haematocrit values in Limousin cattle : influence of body weight decrease 显示文摘FAZIO E MEDICA P ALBERGHINA D 2005Veterinary Research Communications2005,29,8:1
11Surface- wave pyroelectric photorefractive solitons 显示文摘SAFIOUI J FAZIO E DEVAUX F 2010Opt Lett2010,35,8:1
12Simplified generation of all mechan-ical assembly sequence显示文摘De Fazio T L Whitney D E 1987IEEE Journal of Robotics andAutomations1987,3,6:1
13Simplified generation of all mechanical assembly sequences显示文摘Fazio De T Whitney D E 1987IEEE Journal Robotics and Automation1987,3,6:1
14Simplified generation of all mechanical assembly sequences 显示文摘DE FAZIO T L WHITNEY D E 1987IEEE Journal of Robotics and Automation1987,3,:1
15Simplified generation of all mechanical assembly sequences显示文摘Fazio D Whitney D E 1987IEEE Transactions on Robotics and Automation1987,3,6:1
16Substituted 2 diones as fatty acid amide hydrolase inhibitors templates显示文摘Muccioli G G Fazio N Scriba G K E 2006J Med Chem2006,49,:1
17Simplified generation of all mechanical assembly sequences 显示文摘DE FAZIO T L WHITNEY D E 1987IEEE Journal of Robotics and Automation1987,3,6:1
18Simplified generation of all mechanical assembly sequences 显示文摘FAZIO D T WHITNEY D E 1987IEEE Journal Robotics and Automation1987,3,6:1
19Simplified generation of all mechanical assembly sequences显示文摘 Whitney D E 1987IEEE Transactions on Robotics and Automation1987,3,6:1
20Beam-cavity ineraction physics for middly relativistic,intense-beam klystron amplifier显示文摘Carlsten B E Faehl R J Fazio M V 0,,05:1
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