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| 1 | Bartter's syndrome:clinical findings,genetic causes and therapeutic approach显示文摘Backgound Bartter's syndrome(BS)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's loop.Data sources Literature reviews and original research articles were collected from database,including PubMed and Scopus.Results According to the time of onset and symptoms,BS can be classified into antenatal and classic BS.Molecular studies have identified different subtypes of BS.BS types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),respectively.Loss-of-function mutations of Barttin CLCNK type accessory beta subunit cause BS type Ⅳa.Simultaneous mutations of CLCNKB and CLCNKA cause BS type Ⅳb.BS type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGE family member D2.Severe gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of BS.Main clinical and biochemical alterations in BS include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to thrive.Treatment focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin E2 production.Conclusions Early diagnosis and treatment of BS may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease. | Flavia Cristina Carvalho Mrad Sílvia Bouissou Morais Soares Luiz Alberto Wanderley de Menezes Silva Pedro Versiani dos Anjos Menezes Ana Cristina Simoes-e-Silva | 2021 | World Journal of Pediatrics2021，17，1： | 10 |
| 2 | Neutrophil transcriptional profile changes during transii from bone marrow to sites of inflammation显示文摘 | Flavia S Lakschevitz Michelle B Visser Chunxiang Sun Michael Glogauer | 2015 | Cellular & Molecular Immunology2015，12，1： | 3 |
| 3 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 4 | Seasonal changes of ener- gy reserves in Bulimulus tenuissimus (d' Orbigny, 1835 )(Mollusca, Bulimulidae)显示文摘 | Lidiane S Liliane M Flavia OJ et ol | 2012 | Anim Bioi2012，62，1： | 1 |
| 5 | Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species 显示文摘 | FLAVIA N I MIKE F Q CRISTINA S | 2002 | Plant Physiol Biochem2002，40，： | 1 |
| 6 | Rapid,simple,and low-cost identification of Candida species using high-resolution melting analysis显示文摘 | Silvia A Silvia S Flavia DB | | 0，，03： | 1 |
| 7 | Direct anal ysis of antarctic krill by slurry sampling: determination of copper, iron, manganese and zinc by flame atomic absorption spectrometry显示文摘 | FLAVIA L A PATRICIA S SILVIA F | 2000 | Journal of the Brazilian Chemical Society2000，11，4： | 1 |
| 8 | Use of double bulk cur- rent injection for susceptibility testing of avionics显示文摘 | Flavia G Giordano S Filippo M | 2008 | IEEE Transactions on Electromagnetic Compatibility2008，50，3： | 1 |
| 9 | A Comparative Study of Diesel Analysis by FTIR,FTNIR and FT-Raman Spectroscopy Using PLS and Arti-ficial Neural Network Analysis显示文摘 | Vianney O S J Flavia C C O Daniella G L | 2005 | Analytica Chimica Acta2005，547，2： | 1 |
| 10 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 11 | Conglomerated masses of silicosis in sandhlasters: High-resolution CT fndings显示文摘 | EDSON M ANGELA F FLAVIA S | 2006 | European Journal of Radiology2006，59，： | 1 |
| 12 | IL-6 -deficient mice show impaired inflammatory response in a model of myosin induced experimental myositis 显示文摘 | FLAVIA S MANNELLA F MARINO M | 2006 | Journal of Neuroimmunology2006，176，： | 1 |
| 13 | Biofilm development and cell death in the marine bacterium Pseudoalteromona tunicate显示文摘 | ANNE M P FLAVIA E DORALYN D S | 2004 | Applied and Environmental Microbiology2004，7，70： | 1 |
| 14 | TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts显示文摘 | Mariapaola M Flavia S Francesca M | 2003 | J Neuroimmunol2003，134，1： | 1 |
| 15 | Conglomerated masses of silicosis in sandblastersz High-resolution CT ndings显示文摘 | EDSON M ANGELA F FLAVIA S | 2006 | European Journal of Radiology2006，59，： | 1 |
| 16 | Determination of ethanol in fuel ethanol and beverages by Fourier transform(FT)-near infrared and FTRaman spectrometries显示文摘 | Leornardo S M Flavia C C O Paulo A Z S | 2003 | Analytica Chimica Acta2003，493，： | 1 |
| 17 | Determination of ethanol in fuel ethanol and beverages by Fourier transform (FT)-near infrared and FT- Raman spectrometries显示文摘 | Leornardo S M Flavia C C Paulo A Z | 2003 | Analytica Chimica Acta2003，493，2： | 1 |
| 18 | Mobilization and r-ecovery of energy stores in trai′ra,Hoplias malabaricus bloch(Teleostei,Erythrinidae)during long-term starvation and after re-feeding显示文摘 | Flavia S R Gilberto M Eliane T O | 2006 | Comp Physiol B2006，176，： | 1 |
| 19 | Lipoic acid:a unique antioxidant in the detoxification of activated oxygen species显示文摘 | Flavia N I Mike F Q Cristina S | 2002 | Plant Physiol Biochem2002，40，： | 1 |
| 20 | TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts显示文摘 | Mariapaola M Flavia S FrancescaM | | 0，，1： | 1 |
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