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| 1 | Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms显示文摘Hepatitis C virus(HCV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess mortality.Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and stroke.In contrast,findings from studies addressing coronary artery disease and HCV have yielded conflicting results.Therefore,meta-analytic reviews and prospective studies are warranted.The pathogenic mechanisms connecting HCV infection,chronic liver disease,and atherogenesis are not completely understood.However,it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic syndrome.Understanding these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV infection.Currently,it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke. | Luigi E Adinolfi Rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni Anna Florio Paola Loria | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Quercetin as a novel ac- tivator of Ltype Caz+ channels in rat tail artery smooth muscle cells显示文摘 | Saponara S Giampietro S Fabio E | 2002 | Br J Pharmaeol2002，135，7： | 1 |
| 4 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 5 | Stem cell therapy for autism显示文摘 | Fabio S Eduardo G | 2007 | Journal of Translational Medicine2007，5，： | 1 |
| 6 | Primary dural lymphomas:A clinicopathologic study of treatment and outcome in eight patients显示文摘 | Fabio M Lisa M Lauren E | 2006 | Neurology2006，66，： | 1 |
| 7 | Inhibition of anchorage dependent cell spreading triggers apoptosis in cultured human edothelial cell显示文摘 | Fabio R Zanetti A Sironi M Polentarutti N Lanfrancone L Dejana E | 1994 | Cell Biol1994，127，3： | 1 |
| 8 | Genetic algorithm optimization of X-ray muhilayer coatings显示文摘 | Fabio E Zochhi | 2001 | Proc of SPIE2001，5536，： | 1 |
| 9 | Robust estimation in time series with long and short memory properties 显示文摘 | Vald e rio Anselmo Reisen Fabio Fajaxdo Molinares | 2012 | Annales Mathematicae et Informaticae2012，，39： | 1 |
| 10 | Effect of soy-derived isoflavones hot flushes,endometrial thickness,and the pulsatility index of the uterine and cerebral arteries显示文摘 | Fabio E Modena A B | 2003 | Fertil Steril2003，79，： | 1 |
| 11 | (Z)-Tamoxifen and tetrasubstituted Alkenes and Dienes via a region-and stereospecific three-component magnesium carbometalation palladium(o) cross-coupling strategy显示文摘 | Pierre E T Andrea J P Fabio E S and Alex G F | 2003 | 5(17):2989-29922003，5，17： | 1 |
| 12 | N-(carboxymethylidene)chitosans and N-(carboxymethyl)chitosans:Novel chelating polyampholytes obtained from chitosan glyoxylate显示文摘 | Riccardo AAM Fabio T Monica E | 1982 | Carbohydr Res1982，107，2： | 1 |
| 13 | Changes in soil carbon and nutrient pools along a ehronosequence of poplar plantations in the Columbia Plateau, Oregon, USA显示文摘 | Fabio S Rattan L Michael H E | 2007 | Agriculture Ecosystems and Environment2007，122，3： | 1 |
| 14 | 15K 显示文摘 | Fabio C Romolo E Thermodynamic properties of binary mix- tures containing 1 2-epoxybutane + four alkanols at 298 | 1996 | J Chem Eng Data1996，41，6： | 1 |
| 15 | Contrast echocardiography and migraine in divers with patent foramen ovale显示文摘 | Di Fabio R Giugni E Angeloni I | 2009 | Can J Neurol Sci2009，36，： | 1 |
| 16 | Phase I1 study of panitumumab, oxaliplatin, 5-fluorouracil, and concurrent radiotherapy as preoperative treatment in high-risk locally advanced rectal cancer patients (StarPan/STAR-02 Study) 显示文摘 | Pinto C Di Fabio F Maiello E | 2011 | Ann Oncol2011，22，： | 1 |
| 17 | Optical coupling from plane wave to step-index single-mode fiber 显示文摘 | Lazzaroni Massimo Zocchi Fabio E | 2004 | Optics Communications2004，237，： | 1 |
| 18 | Sourdough in gluten-free bread making: an ancient technology to solve a novel issue? 显示文摘 | MORONI A V FABIO D B ARENDT E K | 2009 | Food Mocrohiology2009，26，7： | 1 |
| 19 | Image-based 3D Modeling: A Review显示文摘 | Fabio R Sabry E H | 2006 | The Photogrametric Record2006，21，115： | 1 |
| 20 | Commercial DNA probes for mycobacteria incorrectly Identify a number of less frequently encountered species显示文摘 | Tortoli E Pecorari M Fabio G | 2010 | J Clin Microbiol2010，48，： | 1 |
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