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| 1 | Post reperfusion syndrome during liver transplantation:From pathophysiology to therapy and preventive strategies显示文摘This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A Pub Med search was conducted using the Me SH database, 'Reperfusion' AND 'liver transplantation' were the combined Me SH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies. | Antonio Siniscalchi Lorenzo Gamberini Cristiana Laici Tommaso Bardi Giorgio Ercolani Laura Lorenzini Stefano Faenza | 2016 | World Journal of Gastroenterology2016，22，4： | 20 |
| 2 | Role of epidural anesthesia in a fast track liver resection protocol for cirrhotic patients-results after three years of practice显示文摘AIM To evaluate the potential benefits and risks of the use of epidural anaesthesia within an enhanced recovery protocol in this specific subpopulation.METHODS A retrospective review was conducted, including all cirrhotic patients who underwent open liver resection between January 2013 and December 2015 at Bologna University Hospital. Patients with an abnormal coagulation profile contraindicating the placement of an epidural catheter were excluded from the analysis. The control group was composed by patients refusing epidural anaesthesia. RESULTS Of the 183 cirrhotic patients undergoing open liver resections, 57 had contraindications to the placement of an epidural catheter; of the remaining 126, 86 patients received general anaesthesia and 40 combined anaesthesia. The two groups presented homogeneous characteristics. Intraoperatively the metabolic data did not differ between the two groups, whilst the epidural group had a lower mean arterial pressure(P = 0.041) and received more colloid infusions(P = 0.007). Postoperative liver and kidney function did not differ significantly.Length of mechanical ventilation(P = 0.003) and hospital stay(P = 0.032) were significantly lower in the epidural group. No complications related to the epidural catheter placement or removal was recorded.CONCLUSION The use of Epidural Anaesthesia within a fast track protocol for cirrhotic patients undergoing liver resections had a positive impact on the patient's outcomes and comfort as demonstrated by a significantly lower length of mechanical ventilation and hospital stay in the epidural group. The technique appears to be safely manageable in this fragile population even though these results need confirmation in larger studies. | Antonio Siniscalchi Lorenzo Gamberini Tommaso Bardi Cristiana Laici Elisa Gamberini Letizia Francorsi Stefano Faenza | 2016 | World Journal of Hepatology2016，8，26： | 13 |
| 3 | Ventilator associated pneumonia following liver transplantation:Etiology,risk factors and outcome显示文摘AIM: To determine the incidence, etiology, risk factors and outcome of ventilator-associated pneumonia(VAP) in patients undergoing orthotopic liver transplantation(OLT).METHODS: This retrospective study considered 242 patients undergoing deceased donor OLT. VAP was diagnosed according to clinical and microbiological criteria. RESULTS: VAP occurred in 18(7.4%) patients, with an incidence of 10 per 1000 d of mechanical ventilation(MV). Isolated bacterial etiologic agents were mainly Enterobacteriaceae(79%). Univariate logistic analysis showed that model for end-stage liver disease(MELD) score, pre-operative hospitalization, treatment with terlipressin, Child-Turcotte-Pugh score, days of MV and red cell transfusion were risk factors for VAP. Multivariateanalysis, considering significant risk factors in univariate analysis, demonstrated that pneumonia was strongly associated with terlipressin usage, pre-operative hospitalization, days of MV and red cell transfusion. Mortality rate was 22% in the VAP group vs 4% in the group without VAP. CONCLUSION: Our data suggest that VAP is an important cause of nosocomial infection during postoperative period in OLT patients. MELD score was a significant risk factor in univariate analysis. Multiple transfusions, treatment with terlipressin, preoperative hospitalization rather than called to the hospital while at home and days of MV constitute important risk factors for VAP development. | Antonio Siniscalchi Lucia Aurini Beatrice Benini Lorenzo Gamberini Stefano Nava Pierluigi Viale Stefano Faenza | 2016 | World Journal of Transplantation2016，6，2： | 9 |
| 4 | Thoracic epidural anesthesia:Effects on splanchnic circulation and implications in Anesthesia and Intensive care显示文摘AIM: To evaluate the currently available evidence on thoracic epidural anesthesia effects on splanchnic macro and microcirculation, in physiologic and pathologic conditions.METHODS:A Pub Med search was conducted using the Me SH database.Anesthesia,Epidural was always the first MeS H heading and was combined by boolean operator AND with the following headings:Circulation,Splanchnic;Intestines;Pancreas and Pancreatitis;LiverFunction Tests.EMBASE,Cochrane library,ClinicalT rials.gov and clinicaltrialsregister.eu were also searched using the same terms.RESULTS:Twenty-seven relevant studies and four ongoing trials were found.The data regarding the effects of epidural anesthesia on splanchnic perfusion are conflicting.The studies focusing on regional macro-hemodynamics in healthy animals and humans undergoing elective surgery,demonstrated no influence or worsening of regional perfusion in patients receiving thoracic epidural anesthesia(TEA).On the other hand most of the studies focusing on micro-hemodynamics,especially in pathologic low flow conditions,suggested that TEA could foster microcirculation.CONCLUSION:The available studies in this field are heterogeneous and the results conflicting,thus it is difficult to draw decisive conclusions.However there is increasing evidence deriving from animal studies,that thoracic epidural blockade could have an important role in modifying tissue microperfusion and protecting microcirculatory weak units from ischemic damage,regardless of the effects on macro-hemodynamics. | Antonio Siniscalchi Lorenzo Gamberini Cristiana Laici Tommaso Bardi Stefano Faenza | 2015 | World Journal of Critical Care Medicine2015，4，1： | 8 |
| 5 | Kidney preservation with University of Wisconsin and Celsior solution;a prospective multicenter randomized study 显示文摘 | Faenza A Catena F Nardo B | 2001 | Transplantation2001，72，7： | 1 |
| 6 | Kidney preser vation with University of Wisconsin and Celsior solutions:a prespective multicenter randomized study显示文摘 | FAENZA A CATENA F NARDO B | 2001 | Transplantation2001，72，7： | 1 |
| 7 | Free fibular flap with pe- riosteal excess for mandibular reconstruction 显示文摘 | Trignano E Fallico N Faenza M | 2013 | Microsurgery2013，33，7： | 1 |
| 8 | Free fibular flap with periosteal excess for mandibular reconstruction显示文摘 | Trignano E Fallico N Faenza M | 2013 | Microsurgery2013，33，7： | 1 |
| 9 | Prometheus system: a technological support in liver failure 显示文摘 | Santoro A Faenza S Mancini E | 2006 | Transplantation Proceedings2006，38，： | 1 |
| 10 | A role for nuclear phospholipase Cbeta 1 in cell cycle control显示文摘 | Matteucci A Manzoli L | 2000 | J Biol chem2000，275，30： | 1 |
| 11 | Plasma separation and bilirubin adsorption for excessive hyperbilirubinemia before and after liver transplantation显示文摘 | Mancini E Faenza S Mambelli E | 2002 | Critical Care2002，6，1： | 1 |
| 12 | Intranuclear3-phosphoinositide metabolism and Akt signaling:new mechanisms for tumorigensis and protection against apoptosis ?显示文摘 | Marteni AM Faenza I Bili AM etal | 2006 | Cell signal2006，18，8： | 1 |
| 13 | Gastrointestinal Perforations Following Kidney Transplantation显示文摘 | F. Catena L. Ansaloni F. Gazzotti R. Bertelli S. Severi F. Coccolini G. Fuga B. Nardo L. D’Alessandro A. Faenza A.D. Pinna | 2008 | Transplantation Proceedings2008，，6： | 1 |
| 14 | Hyperdynamic Circulation in Acute Liver Failure: Reperfusion Syndrome and Outcome Following Liver Transplantation显示文摘 | A. Siniscalchi A. Dante S. Spedicato L. Riganello A. Zanoni M. Cimatti E. Pierucci E. Bernardi Z. Miklosova C. Moretti S. Faenza | 2010 | Transplantation Proceedings2010，，4： | 1 |
| 15 | Intranuclear 3 '- phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? 显示文摘 | Martelli AM Faenza I Billi AM | 2006 | Cell Signal2006，18，8： | 1 |
| 16 | Kidney preservation with university of Wisconsin and Celsior solution: a prospective multicenter randomized study显示文摘 | Faenza A Catena F Nardo B | 2001 | Transplantation2001，72，7： | 1 |
| 17 | lntranuelear 3'-phosphpinusitide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptsis 显示文摘 | Martelli AM Faenza 1 Billi AM | 2006 | Cell Signal2006，18，8： | 1 |
| 18 | Intranuclear 3'- phosphoinositide metabolism and Akt signaling:new mechanisms for tumorigenesis and protection againstapoptosis显示文摘 | Martelli AM Faenza I Billi AM | 2006 | Cell Signal2006，18，8： | 1 |
| 19 | Statistical occurrence analysis and spatio-temporal distribution of earthquakes in the Apennines (Italy) 显示文摘 | Faenza L Pierdominici S | 2007 | Tectonophysics2007，439，14： | 1 |
| 20 | Ureteral stenosis after kidney transplantation显示文摘 | A. Faenza Bruno Nardo Fausto Catena Maria P. Scolari Giovanni Liviano d’Arcangelo Andrea Buscaroli Cristina Rossi Maurizio Zompatori | 1999 | Transplant International1999，，5： | 1 |
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