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| 1 | Microstructures and tensile properties of Mg-Zn-(Gd)-Zr alloys extruded at various temperatures显示文摘The microstructures and tensile properties of Mg-6.0 Zn-0.6 Zr(ZK60) and ZK60 + 1.8 Gd(ZEK620(RE = Gd)) alloys extruded at 290, 305, 320, 340 and360 ℃ were investigated. The results indicate that Gd addition can refine the microstructures of ZK60 alloy and the extrusion parameters such as the extrusion temperature will influence the tensile properties of both as-extruded ZK60 and ZEK620 alloys, although it is much slighter for ZK60 alloy. And the sensitivity is closely related to the textures developed during extrusion. In addition, Gd addition will also clearly improve the tensile strength at room temperature(24 ℃) and particularly at high temperatures(150 and 200 ℃), due to the much finer grains and smaller intermetallic particles. The highest strength is achieved in the as-extruded ZEK620 alloy with extrusion temperature of 320 ℃, with ultimate tensile strength(UTS) and tensile yield strength(TYS) of 405 and375 MPa, respectively, which are improved by approximately 9% and 11% than those of the as-extruded ZK60 alloy which owns the highest strength at extrusion temperature of 290 ℃. | Xin Qiu Qiang Yang Kai Guan Fanqiang Bu Zhan-Yi Cao Yong-Bing Liu Jian Meng | 2017 | Rare Metals2017，36，12： | 9 |
| 2 | Effects of substitution of Nd in a sand-cast Mg-2.5Nd-0.6Zn-0.5Zr alloy with x wt.% Sm(x=2.5, 4, and 6)显示文摘The microstructures and mechanical properties of a series of sand-cast Mg-Sm-Zn-Zr alloys under ascast, solution-treated and peak-aged states were thoroughly investigated. The OM, XRD, SEM and HRTEM were employed to characterize the microstructural evolution. The results indicate that substitution Nd in the conventional Mg-2.5 Nd-0.6 Zn-0.5 Zr alloy with different contents of Sm has comparative grain refinement effect and will fully change the dominant intermetallic phase. In addition, the substituted alloys perform clearly higher strength with comparative ductility at both as-cast and peakaged conditions and much greater aging hardening response than the referential alloy. It is obvious that the strength increments of this alloy are attributed to the changes of the eutectic intermetallic particles on grain boundaries. | Deping Zhang Qiang Yang Dongdong Zhang Kai Guan Fanqiang Bu Hong Zhou Jian Meng | 2017 | Journal of Rare Earths2017，35，12： | 5 |
| 3 | Ultrafine Grain Formation in Mg-Zn Alloy by in situ Precipitation during High-Pressure Torsion显示文摘 | Fanqiang Meng Julian M. Rosalie Alok Singh Hidetoshi Somekawa Koichi Tsuchiya | 2014 | Scripta Materialia2014，，： | 1 |
| 4 | Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer显示文摘Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell exhaustion.Immune checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer treatment.However,the limited clinical response rate and off-tumor toxicities restrict ICB therapy.Herein,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract cancer.The nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 blockade.Furthermore,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer cells.Hence,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis. | Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang Fangfang Duan Fanqiang Meng Xin Liang Xudong Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 5 | Recursive Dictionary-Based Simultaneous Orthogonal Matching Pursuit for Sparse Unmixing of Hyperspectral Data显示文摘The sparse unmixing problem of greedy algorithms still remains a great challenge at finding an optimal subset of endmembers for the observed data from the spectral library,due to the usually high correlation of the spectral library.Under such circumstances,a novel greedy algorithm for sparse unmixing of hyperspectral data is presented,termed the recursive dictionary-based simultaneous orthogonal matching pursuit(RD-SOMP).The algorithm adopts a block-processing strategy to divide the whole hyperspectral image into several blocks.At each iteration of the block,the spectral library is projected into the orthogonal subspace and renormalized,which can reduce the correlation of the spectral library.Then RD-SOMP selects a new endmember with the maximum correlation between the current residual and the orthogonal subspace of the spectral library.The endmembers picked in all the blocks are associated as the endmember sets of the whole hyperspectral data.Finally,the abundances are estimated using the whole hyperspectral data with the obtained endmember sets.It can be proved that RD-SOMP can recover the optimal endmembers from the spectral library under certain conditions.Experimental results demonstrate that the RD-SOMP algorithm outperforms the other algorithms,with a better spectral unmixing accuracy. | Kong Fanqiang Guo Wenjun Shen Qiu Wang Dandan | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 1 |
| 6 | 显示文摘 | LiuZhenliang(刘振良) LiaoZhijun(廖志君) FanQiang(范强)eta1 | 2009 | 稀有金属材料与工程2009，38，2： | 1 |
| 7 | Classical Generators of Special Unitary Group SU(R) in Quantum System显示文摘 | LI Chang'e BU Fanqiang TAO Yuanhong | 2014 | Journal of Jilin University (Science Edition)2014，52，1： | 1 |
| 8 | Moiré heterostructures:highly tunable platforms for quantum simulation and future computing显示文摘Moiré heterostructures, where the constituent 2D materials are stacked vertically at a small angle, feature longwavelength interference pattern at the van der Waals interfaces. One typical example is twisted bilayer graphene. In this moiré heterostructure, the emergence of moiré superlattices can effectively reconstruct the energy bands into dispersionless flat bands at a special twisted angle(so-called ‘magic angle’). | Moyu Chen Fanqiang Chen Bin Cheng Shi Jun Liang Feng Miao | 2023 | Journal of Semiconductors2023，44，1： | 0 |
| 9 | Analysis of College Students' life views and life education strategy显示文摘 | ZHENG Fanqiang | 2017 | International English Education Research2017，，4： | 0 |
| 10 | Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia显示文摘Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of it.Lacticaseibacillus rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine degradation rate reached 36.3%at 109 CFU/mL for 24 h.LC-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of L.rhamnosus Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and riboflavin.The contents of folic acid and riboflavin were 6.0 and 4.3 fold increased after inosine treatment in the cell-free extracts(CFE).L.rhamnosus Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase(XOD)inhibition and ATP-binding cassette subfamily G member 2(ABCG2)promotion,both of which are responsible for uric acid(UA)synthesis and secretion in HepG2 and Caco2 cells,respectively.The in vivo results showed that the serum UA level decreased from 236.28 to 149.28μmol/L after 8 weeks of oral administration of L.rhamnosus Fmb14 in inosine-induced hyperuricemia model mice.Our results revealed that L.rhamnosus Fmb14 has a potential as a biological therapeutic agent in hyperuricemia prevention. | Hongyuan Zhao Xiaoyu Chen Fanqiang Meng Libang Zhou Xinyi Pang Zhaoxin Lu Yingjian Lu | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 11 | PRACTICAL APPLICATION AND SOME TREATMENT SKILL OF GEOTECHNICAL NUMERICAL MODELLING TECHNIQUES FOR COAL MINING DESIGN AND THE SOLUTION OF MINING PROBLEMS显示文摘This paper focuses on the following topics: (1). development and practical application of numerical modelling capabilities to investigate methods of improving coal recovery related with underground coal mining;(2). some treatment skill such as rock mass failure treatment, model calibration requirements, etc.; (3). comparison between results of modelling and underground monitoring. Application shows that numerical modelling is a useful tool for investigation of many coal mining design problems, in both maor and minor roles. Modelling can be used as an integral part of mine planning and the solution of mining | YAO Jianguo GUO Fanqiang DU Zhongxiao(Central Coal Mining Research Institute Beijing, P.R.CHINA) | 1995 | Journal of Coal Science & Engineering(China)1995，1，1： | 0 |
| 12 | Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by Bacillus amyloliquefaciens显示文摘Bacillomycin D is a cyclic lipopeptide produced by Bacillus amyloliquefaciens fmbJ.At present,no relevant report has described the combinatorial biosynthesis of bacillomycin D.Due to the strong biosynthetic potential of the communication-mediating(COM)domains,its crosstalk between NRPS subunits has been studied to some extent,but the interaction of COM domain between modules is rarely reported.Therefore,in this study,we conducted the combinatorial biosynthesis of bacillomycin D through the deletion of the COM donor and acceptor domains between the modules and elucidated the interaction between the NRPS modules.The results showed that the deletion of the donor domain between modules 2 and 3 did not affect catalysis by upstream modules,but prevented downstream modules from catalysing the extension of the lipopeptide product,ultimately resulting in mutant complexes that could form linear dipeptides with the sequenceβ-NH_(2)FA-Asn-Tyr.However,the engineered hybrid bacillomycin D NRPSs lacking the donor domains between modules 3 and 4 and modules 6 and 7 could form multiple assembly lines that produced bacillomycin D and its analogs(linear tripeptides,cyclic hexapeptides and linear hexapeptides).In addition,all the acceptor domain deletion strains failed to produce bacillomycin D,only truncated peptides produced by module interruption(except for the acceptor domain deletion strains between modules 3 and 4,which also produced cyclic hexapeptides).In conclusion,deletion of the inter-module donor domains led to a more flexible hybrid biosynthetic system for the production of diverse peptide products;compared with the inter-subunit donor domain deletion strains that could only produce truncated peptides,the former had a greater biosynthetic capacity.Meanwhile,the acceptor domains between modules were an important part of module-module interactions and efficient communication within bacillomycin D synthetase. | Ziyan Lv Wenjie Ma Ping Zhang Zhaoxin Lu Libang Zhou Fanqiang Meng Zuwei Wang Xiaomei Bie | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 0 |
| 13 | 玩转命令行——下载工具wget显示文摘用烦了FlashGet。想换个下载工具试试?wgat可能是一个不错的选择,它虽然只是一个命令行工具,但功能之强大、设置选项之众多,在目前的下载工具中可能还无出其右者,而且还支持Windows、Linux、UNIX等众多操作平台…… | FanQiang | 2005 | 计算机应用文摘2005，，18： | 0 |
| 14 | Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin显示文摘Type 2 diabetes mellitus(T2DM)is associated with liver dysfunction and intestinal dysbiosis.Bioactive peptides(BAPs)have been reported to ameliorate T2DM by preventing oxidative damage to the liver.Bacillus amyloliquefaciens fmb50 produces the lipopeptide surfactin with a wide range of biological activities.The effects of surfactin on T2DM,on the other hand,have not been studied.In the present study,80 mg/kg body weight surfactin supplementation lowered fasting blood glucose(FBG)levels by 21.05%and insulin resistance(IR)by 18.18%compared with those in the T2DM group,reduced inflammation,and increased antioxidant activity in mice with T2DM induced by a high-fat diet(HFD)and streptozotocin(STZ).According to further research,surfactin administration reduced Firmicutes-to-Bacteroidetes ratios while increasing Bifi dobacterium abundance by 20 times and the level of the tight junction protein Occludin by 18.38%and ZO-1 by 66.60%.Furthermore,surfactin also improved hepatic glucose metabolism by activating the adenosine monophosphate-activated protein kinase(AMPK)signalling pathway,increasing glycogen synthesis and glucose transporter 2(GLUT2)protein expression while reducing glucose-6-phosphatase(G6Pase)protein expression.In addition,the increased Bifi dobacterium abundance indirectly reduced the liver burden of the metabolic products indole,cresol and amine produced by saprophytic bacteria.All of these findings revealed that surfactin not only ameliorated HFD/STZ-induced gut dysbiosis and preserved intestinal barrier integrity but also enhanced hepatic glucose metabolism and detoxifi cation function in T2DM mice.The gut microbiota appeared to be important in controlling glucose metabolism,IR,fat accumulation,inflammation and antioxidation,according to Spearman’s correlation coeffi cients.All data indicated that surfactin alleviated hyperglycaemia in mice with T2DM induced by HFD/STZ. | Xiaoyu Chen Hongyuan Zhao Fanqiang Meng Libang Zhou Zhaoxin Lu Yingjian Lu | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
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