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| 1 | Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis显示文摘BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes.AIM To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMR) of colorectal lesions ≥ 20 mm.METHODS We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects model.RESULTS Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P < 0.001) following EMR of lesions ≥ 20 mm.There was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMR of large colorectal lesions.Future trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy. | Fares Ayoub Donevan R Westerveld Justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang | 2019 | World Journal of Gastroenterology2019，25，18： | 9 |
| 2 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl_4-induced hepatocellular carcinoma in Wistar rats显示文摘Objective:To investigation the chemopreventive potential of Fumaria indica(F.indica) extract(FIE) on N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Wislar rats.Methods:The experimental animals were divided into six groups(n=6).Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine(NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl4(3 mL/kg/week) for 6 weeks,as the promoter of carcinogenic effect.After administration of the carcinogen,200 and 400 mg/kg of FIE were administered orally once a day throughout the study.At the end of 20 weeks,the body weight,liver weight and relative liver weight were measured.The percentage of nodule incidence and liver cancer markers such as aspartate transaminase(AST),alanine transaminase(ALT),alkaline phosphatase(ALP),γ-glutamyl transferase(γ-GT),total bilirubin level(TBL),α-feto protein(AFP) and carcinoembryonic antigen were estimated along with histopathological investigation in experimental groups of rats. Results:Obtained results demonstrated that the cotreatment with FIE significantly prevented the decrease of the body weight and also increased in relative liver weight caused by NDEA. The treatment with FIE significantly reduced the nodule incidence and nodule multiplicity in the rats after NDEA administration.The levels of liver cancer markers such as AST,ALT,ALP,γ-glutamyl transferase,TBL,AFP and carcinoembryonic antigen were substantially increased by NDEA treatment.However,FIE treatment significantly reduced the liver injury and restored the entire liver cancer markers.Histological observations of liver tissues too correlated with the biochemical observations.Conclusions:These finding powerfully supports that F.indica exert chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wistar rats. | Talib Hussain Hefazat H Siddiqui Sheeba Fareed M Vijayakumar Chandana V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 3 |
| 3 | Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates显示文摘 | Stief TW Jeske WP Walenga J Schultz C Kretschmer V Fareed J | 2001 | Clin Appl Thromb Hemost2001，7，3： | 1 |
| 4 | S-adenosylmethionine decarboxylase activity and utilization of exogenous putrescine are enhanced in colon cancer cells stimulated to grow by EGF显示文摘 | Milovic V Turhanowa L Fares FA | 1998 | Z Gastroenterol1998，36，11： | 1 |
| 5 | Pollution abatement and productivity growth: Evidence from Germany, Japan, the Netherlands, and the United States显示文摘 | Aiken D V Fare R Grosskopf S | 2009 | Environmental and Resource Economics2009，44，： | 1 |
| 6 | Evaluation of a non-point source pollution model, AnnAGNPS, in a tropical watershed显示文摘 | Polyakov V Fares A Kubo D | 2007 | Environmental Modelling Software2007，22，16： | 1 |
| 7 | Evaluation of a nonpoint source pollution model,Ann AGNPS,in a tropical watershed显示文摘 | Polyakov V Fares A Kubo D | 2007 | Environmental Modelling&Software2007，22，11： | 1 |
| 8 | Robust 285 nm deep UV light emitting diodes over metal or- ganic hydride vapor phase epitaxially grown A1N/sapphire templates显示文摘 | ADIVARAHAN V FAREED Q SRIVASTAVA S | 2007 | Japanese Journal of Applied Physics2007，46，23： | 1 |
| 9 | A case of fatal intoxication from mefformin显示文摘 | Gambaro V Dell'acqua L Fare F | 2007 | J Forensic Sci2007，52，4： | 1 |
| 10 | Determination of primary active constituents in Cannabis preparations by high-resolution gas chromatography/flame ionization detection and high-performance liquid ehromatography/UV detection显示文摘 | GAMBARO V DELL'ACQUA L FARE F | 2002 | Anal Claim Acta2002，46，2： | 1 |
| 11 | On aggregate Farrell effieiencies显示文摘 | Fare R Zelenyuk V | 2003 | European Journal of Operational Research2003，146，： | 1 |
| 12 | Evaluation of a Non-Point Sourc Pollution Model, AnnAGNPS, in a Trop ical Watershed 显示文摘 | POLYAKOV V FARES A KUBO D | 2007 | Environment Modeling Software2007，22，11： | 1 |
| 13 | Development and transferability of apricot and grape EST microsatellite markers across taxa显示文摘 | Decroocq V Fare M G Hagen L | 2003 | Theor Appl Genet2003，106，： | 1 |
| 14 | Advances in crop water management using capacitive water sensors显示文摘 | Fares A Polyakov V | 2006 | Advances in Agronomy2006，90，： | 1 |
| 15 | Evaluation of a non-point source pollution model,AnnAGNPS,in a tropical watershed显示文摘 | Polyakov V Fares A Kubo D | | 0，，22： | 1 |
| 16 | Pollution abatement and productivity growth:Evidence from Germany,Japan,the Netherlands,and the United States显示文摘 | AIKEN D V FARE R GROSSKOPF S | 2009 | Environmental and Resource Economics2009，，44： | 1 |
| 17 | Evaluation of a non-point source pollution model, AnnAGNPS, in a tropical watershed显示文摘 | Polyakov V Fares A Kubo D | 2007 | Environmental Modelling & Software2007，，： | 1 |
| 18 | Precision riparian buffers for the control of nonpoint source pollutant loading into surface water: a review 显示文摘 | Polyakov V Fares A Ryder M H | 2005 | Environmental Reviews2005，13，： | 1 |
| 19 | Small diameter electrospun silk fibroin vascular grafts: Mechanical properties, in vitro biodegradability, and in vivo biocompatibility显示文摘 | Catto V Fare S Cattaneo I | 2015 | Mat Sei Eng C-Mater2015，54，： | 1 |
| 20 | Organic-inorganic charge-transfer salts based on theβ-4-isopolyanion-synthesis,properties and X-ray structure显示文摘 | Attanasio D Bonamico M Fares V | 1992 | J Chem Soc Dalton1992，，16： | 1 |
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