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| 1 | nflammasomes in cancer: a double-edgecl sword显示文摘 | Ryan Kolb Guang-Hui Liu Ann M. Janowski Fayyaz S. Sutterwala Weizhou Zhang | 2014 | Protein & Cell2014，5，1： | 34 |
| 2 | Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases显示文摘Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or gene correction provides the potential for transformative therapies to delay or possibly stop further progression of the neurodegenerative disease in affected patients. Adeno-associated virus has been the vector of choice in recent clinical trials of therapies for neurodegenerative diseases due to its safety and efficiency in mediating gene transfer to the central nervous system. This review aims to discuss and summarize the progress and clinical applications of adeno-associated virus in neurodegenerative disease in central nervous system. Results from some clinical trials and successful cases of central neurodegenerative diseases deserve further study and exploration. | Yuan Qu Yi Liu Ahmed Fayyaz Noor Johnathan Tran Rui Li | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 3 | Dynamic characteristics of nanoindentation in Ni:A molecular dynamics simulation study显示文摘In this work,three-dimensional molecular dynamics simulation is carried out to elucidate the nanoindentation behaviour of single crystal Ni.The substrate indenter system is modelled using hybrid interatomic potentials including the manybody potential(embedded atom method) and two-body Morse potential.The spherical indenter is chosen,and the simulation is performed for different loading rates from 10 m/s to 200 m/s.Results show that the maximum indentation load and hardness of the system increase with the increase of velocity.The effect of indenter size on the nanoindentation response is also analysed.It is found that the maximum indentation load is higher for the large indenter whereas the hardness is higher for the smaller indenter.Dynamic nanoindentation is carried out to investigate the behaviour of Ni substrate to multiple loading-unloading cycles.It is observed from the results that the increase in the number of loading unloading cycles reduces the maximum load and hardness of the Ni substrate.This is attributed to the decrease in recovery force due to defects and dislocations produced after each indentation cycle. | Muhammad Imran Fayyaz Hussain Muhammad Rashid S.A.Ahmad | 2012 | Chinese Physics B2012，21，11： | 4 |
| 4 | Seed Priming Influence on Early Crop Growth, Phenological Development and Yield Performance of Linola (Linum usitatissimum L.)显示文摘Reduced early crop growth and limited branching are amongst yield limiting factors of linola. Field response of seed priming treatments viz. 50 mmol L-1 salicylic acid(SA), 2.2% CaCl2 and 3.3% moringa leaf extract(MLE) including untreated dry and hydropriming controls was evaluated on early crop growth and yield performance of linola. Osmopriming with CaCl2 reduced emergence time and produced the highest seedling fresh and dry weights including Chl. a contents. Osmopriming with CaCl2reduced crop branching and fl owering and maturity times and had the maximum plant height, number of branches, tillers, pods and seeds per pod followed by MLE. Increase in seed weight, biological and seed yields was 9.30, 34.16 and 39.49%, harvest index(4.12%) and oil contents(13.39%) for CaCl2 osmopriming. Positive relationship between emergence and seedling vigor traits, 100-seed weight, seed yield with maturity time, 100-seed weight and seed yield were found. The study concludes that seed osmopriming with CaCl2 or MLE can play signifi cant role to improve early crop growth and seed yields of linola. | Hafeez ur Rehman Muhammad Qaiser Nawaz Shahzad Maqsood Ahmed Basra Irfan Afzal Azra Yasmeen Fayyaz ul-Hassan | 2014 | Journal of Integrative Agriculture2014，13，5： | 4 |
| 5 | Molecular dynamics study of the mechanical characteristics of Ni/Cu bilayer using nanoindentation显示文摘In the present work,a three-dimensional molecular dynamics simulation is carried out to perform the nanoindentation experiment on Ni single crystal.The substrate indenter system is modeled using hybrid interatomic potentials including the many-body potential embedded atom method(EAM),and two-body morse potential.To simulate the indentation process,a spherical indenter(diameter = 80 A,1 A=0.1 nm) is chosen.The results show that the mechanical behaviour of a monolithic Ni is not affected by crystalline orientation.To elucidate the effect of a heterogeneous interface, three bilayer interface systems are constructed,namely Ni(100)/Cu(111),Ni(110)/Cu(111),and Ni(111)/Cu(111).The simulations along these systems clearly describe that mechanical behaviour directly depends on the lattice mismatch. The interface with the smaller mismatch between the specified crystal planes is proved to be harder and vice versa.To describe the relationship between film thickness and interface effect,we choose various values of film thickness ranging from 20 A to 50 A to perform the nanoindentation experiment.It is observed that the interface is significant only for the relatively small thickness of film and the separation between interface and the indenter tip.It is shown that with the increase in film thickness,the mechanical behaviour of the film shifts more toward that of monolithic material. | Muhammad Imran Fayyaz Hussain Muhammad Rashid S.A.Ahmad | 2012 | Chinese Physics B2012，21，12： | 3 |
| 6 | A Reliable Stochastic Numerical Analysis for Typhoid Fever Incorporating With Protection Against Infection显示文摘In this paper,a reliable stochastic numerical analysis for typhoid fever incorporating with protection against infection has been considered.We have compared the solutions of stochastic and deterministic typhoid fever model.It has been shown that the stochastic typhoid fever model is more realistic as compared to the deterministic typhoid fever model.The effect of threshold number T*hold in stochastic typhoid fever model.The proposed framework of the stochastic non-standard finite difference scheme(SNSFD)preserves all dynamical properties like positivity,bounded-ness and dynamical consistency defined by Mickens,R.E.The stochastic numerical simulation of the model showed that increase in protection leads to low disease prevalence in a population. | Muhammad Shoaib Arif Ali Raza Muhammad Rafiq Mairaj Bibi Rabia Fayyaz Mehvish Naz Umer Javed | 2019 | Computers, Materials & Continua2019，，6： | 3 |
| 7 | Laser diode partially end-pumped electro-optically Q-switched Yb:YAG slab laser显示文摘A laser diode partially end-pumped, electro-optically Q-switched, Yb:Y3Al5O12(Yb:YAG) slab laser was reported. We obtained output energy of 14.6 mJ/pulse with a pulse width of 30 ns at a repetition frequency of 2 k Hz, and the corresponding peak power was 480 kW. The beam quality factors M2 in the unstable direction and the stable direction was 1.32 and 1.25, respectively. | 高倩 张恒利 Javed Fayyaz | 2019 | Chinese Optics Letters2019，17，11： | 2 |
| 8 | Group psychological intervention for maternal depression: A nested qualitative study from Karachi, Pakistan显示文摘AIM To understand the experience of maternal depression, the factors implicated in accessing health, and the acceptability of the psychosocial intervention. METHODS The participants were recruited from the paediatrics outpatient department of Civil Hospital Karachi, Pakistan. The study started in December 2009 and completed in December 2010. Women with maternal depression, aged 18-44 years with children aged 0-30 mo who had received nutritional supplements, and participated in the intervention programme [called Learning through Play(LTP) plus] were included in the study. Qualitative interviews were conducted with 8 participants before the intervention and 7 participants after the intervention. A semi structured topic guide was used to conduct the interviews.RESULTS Framework analysis procedures were used to analyse the qualitative data. Four themes emerged:(1) the women's contextual environment: Interpersonal conflicts, lack of social support and financial issues being the major barriers in assessing healthcare;(2) women's isolation and powerlessness within the environment: Sense of loneliness was identified as a restricting factor to access healthcare;(3) the impact of the intervention(LTP-Plus): Women felt 'listened to' and seemed empowered; and(4) empowered transformed women within the same contextual environment: The facilitator provided a 'gardening role' in nurturing the women resulting in a positive transformation within the same environment. The women's homes seemed to be more happy homes and there was a positive change in their behaviour towards their children.CONCLUSION Findings informed the further development and testing of culturally-appropriate psychosocial intervention(LTP^+) for addressing maternal depression. | Nusrat Husain Nasim Chaudhry Christine Furber Hina Fayyaz Tayyeba Kiran Farah Lunat Raza Ur Rahman Saira Farhan Batool Fatima | 2017 | World Journal of Psychiatry2017，7，2： | 2 |
| 9 | Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway显示文摘Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been shown to have an effect similar to that of progranulin. Atsttrin has anti-inflammatory actions in multiple arthritis mouse models, and it protects against further arthritis development. However, whether Atsttrin has a role in neuroinflammation remains to be elucidated. In this study, we produced a neuroinflammatory mouse model by intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). Atsttrin(2.5 mg/kg) was administered via intraperitoneal injection every 3 days over a period of 7 days before intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). In addition, astrocyte cultures were treated with 0, 100 or 300 ng/mL lipopolysaccharide, with 200 ng/mL Atsttrin simultaneously. Immunohistochemistry, enzyme-linked immunosorbent assay and real-time reverse transcription-polymerase chain reaction were performed to examine the protein and mRNA levels of inflammatory mediators and to assess activation of the nuclear factor kappa B signaling pathway. Progranulin expression in the brain of wild-type mice and in astrocyte cultures was increased after lipopolysaccharide administration. The protein and mRNA expression levels of tumor necrosis factor-α, interleukin-1β and inducible nitric oxide synthase were increased in the brain of progranulin knockout mice after lipopolysaccharide administration. Atsttrin treatment reduced the lipopolysaccharide-induced increase in the protein and mRNA levels of tumor necrosis factor-α, interleukin-1β, matrix metalloproteinase-3 and inducible nitric oxide synthase in the brain of progranulin knockout mice. Atsttrin also reduced the expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase 3 mRNA in lipopolysaccharide-treated astrocytes in vitro, and decreased the concentration of tumor necrosis factor α and interleukin-1β in the supernatant. Furthermore, Atsttrin significantly reduced the levels of phospho-nuclear factor kappa B inhibitor α in the brain of lipopolysaccharide-treated progranulin knockout mice and astrocytes, and it decreased the expression of nuclear factor kappa B2 in astrocytes. Collectively, our findings show that the anti-neuroinflammatory effect of Atsttrin involves inhibiton of the nuclear factor kappa B signaling pathway, and they suggest that Atsttrin may have clinical potential in neuroinflammatory therapy. | Lian Liu Yuan Qu Yi Liu Hua Zhao He-Cheng Ma Ahmed Fayyaz Noor Chang-Jiao Ji Lin Nie Meng Si Lei Cheng | 2019 | Neural Regeneration Research2019，14，11： | 2 |
| 10 | Structural, electronic, and optical properties of ZnO_(1-x)Se_x alloys using first-principles calculations显示文摘The structural, electronic, and optical properties of binary ZnO, ZnSe compounds, and their ternary ZnO 1-x Se x alloys are computed using the accurate full potential linearized augmented plane wave plus local orbital (FP-LAPW + lo) method in the rocksalt (B1) and zincblende (B3) crystallographic phases. The electronic band structures, fundamental energy band gaps, and densities of states for ZnO 1-x Se x are evaluated in the range 0 ≤ x ≤ 1 using Wu-Cohen (WC) generalized gradient approximation (GGA) for the exchange-correlation potential. Our calculated results of lattice parameters and bulk modulus reveal a nonlinear variation for pseudo-binary and their ternary alloys in both phases and show a considerable deviation from Vegard's law. It is observed that the predicted lattice parameter and bulk modulus are in good agreement with the available experimental and theoretical data. We establish that the composition dependence of band gap is semi-metallic in B1 phase, while a direct band gap is observed in B3 phase. The calculated density of states is described by taking into account the contribution of Zn 3d, O2p, and Se 4s, and the optical properties are studied in terms of dielectric functions, refractive index, reflectivity, and energy loss function for the B3 phase and are compared with the available experimental data. | Muhammad Rashid Fayyaz Hussain Muhammad Imran S A Ahmad N A Noor M U Sohaib S M Alay-e-Abbas | 2013 | Chinese Physics B2013，22，8： | 2 |
| 11 | TORCH screening in polyhydramnios: an observational study 显示文摘 | FAYYAZ H RAFI J | 2012 | The Journal of Maternal - fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine the Federation of Asia and Oceania Perinatal Societies the International Society of Perinatal Obstetricians2012，25，7： | 1 |
| 12 | Value of a baseline ser-um thyrotropin as a predictor of hypothyroidism in patients withdiabetes显示文摘 | Ramasamy V Kadiyala R Fayyaz F | 2011 | Endocr Pract2011，17，1： | 1 |
| 13 | NALP3 : a key player in caspase-1 activation显示文摘 | Fayyaz S Sutterwala Yasunori Ogura | 2006 | J Endot Res2006，12，4： | 1 |
| 14 | TRAIL based therapy: Overview of mesenchymal stem cell based delivery and miRNA controlled expression of TRAIL 显示文摘 | Attar R Sajjad F Qureshi MZ Tahir F Hussain E Fayyaz S et a/ | 2014 | Asian Pac J Cancer Prev2014，15，16： | 1 |
| 15 | TORCH screening in polyhydramnios:an observational study显示文摘 | Fayyaz H Rafi J | | 0，，07： | 1 |
| 16 | TORCH screening in polyhydramnios: an observational study显示文摘 | Fayyaz H Raft J | 2012 | J Matern Fetal Neonatal Med2012，25，7： | 1 |
| 17 | Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own Game显示文摘 | Farooqi AA Fayyaz S Tahir M | 2012 | The Journal of membrane biology2012，245，12： | 1 |
| 18 | Hepatoeellular carcinoma:targeting of oneogenic signaling networks in TRAIL resistant cancer cells 显示文摘 | Fayyaz S Yaylim I Turan S | 2014 | Mol Biol Rep2014，19，37： | 1 |
| 19 | Serotonin receptor modulators in the treatment of irritable bowel syndrome显示文摘 | Fayyaz M Lackne JM | 2008 | Ther Clin Risk Manag2008，4，1： | 1 |
| 20 | Agreement between SPECT V/Q scan and Cangiographyin patients with high clinical suspicion of PE显示文摘 | Mahdavi R Caronid J Fayyaz J | 2013 | Ann Nucl Meal2013，27，9： | 1 |
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