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| 1 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 2 | Transport of iron in the blood-brain-cerebrospinal fluid system显示文摘 | Feelder R A | 1997 | J Neurochem1997，69，2： | 1 |
| 3 | The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 显示文摘 | Hofland LJ van der Hoek J Feelders R | 2005 | Eur J Endocrinol2005，152，4： | 1 |
| 4 | Classification trees for problems with monotonicity constraints显示文摘 | Potharst R Feelders A J | 2002 | SIGKDD Explorations2002，4，1： | 1 |
| 5 | The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5显示文摘 | Hofland LJ van der Hoek J Feelders R | 2005 | Eur J Endocrinol2005，152，4： | 1 |
| 6 | Classification trees for problems with mononicity constrains显示文摘 | POTHARST R FEELDERS A J | | 0，，01： | 1 |
| 7 | Risk Factors for Hemodynamic Instability during Surgery for Pheochromocytoma显示文摘 | BRUYNZEEL H FEELDERS R A GROENLAND T H | | 0，，02： | 1 |
| 8 | The burden of Cushing' s disease : clinical and health - related quality of life aspects 显示文摘 | Feelders R A Pulgar S J Kempel A | 2012 | Eur J Endocrino12012，167，3： | 1 |
| 9 | Thyroid hormone concentrations, disease, physical function, and mortality in elderly men显示文摘 | Van den Beld A W Visser T J Feelders R A | 2005 | J Clin Endocrinol Metab2005，90，12： | 1 |
| 10 | Risk factors for hemodynamic instability during surgery for pheochromocytoma显示文摘 | Bruynzeel H Feelders R A Groenland T H | 2010 | J Clin Endocrinol Metab2010，95，2： | 1 |
| 11 | Pasireotidc, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors 显示文摘 | Feelders R A Herder W W Neggers S J | 2013 | Drugs Today ( Barc )2013，49，2： | 1 |
| 12 | Pro-clinical and clinical experiences with novel somatostatin ligands: advantages, disadvantages and new prospects 显示文摘 | Hofland LJ van der Hoek J Feelders R | 2005 | J Endocrinol Invest2005，28，11： | 1 |
| 13 | Regulation of iron metabolism in the acute-phase response:interferon gamma and tumour necrosis factor alpha induce hypoferraemia,ferritin production and a decrease in circulating transferrin receptors in cancer patients显示文摘 | FEELDERS R A VBEUGDENHIL G EGGERMONT A M | 1998 | Ettr J Clin Invest1998，28，： | 1 |
| 14 | Pre-clinical and clinical experiences with novel somatostatin ligands:advantages,disadvantages and new prospects显示文摘 | Hofland LJ van der Hoek J Feelders R | 2005 | J Endocrinol Invest2005，28，11： | 1 |
| 15 | The multi ligand somatostatin analogue SOM230 inhibits ACTH secre tion by cultured human eorticotroph adenomas via somatosta tin receptor type 5显示文摘 | Holland LJ van der Hock J Feelders R | 2005 | Eur J Endocrinol2005，152，4： | 1 |
| 16 | The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5显示文摘 | Hofland LJ van der Hoek J Feelders R | 2005 | Eur J Endocrinol2005，152，4： | 1 |
| 17 | Cerebrospinal fluid leakage during transsphenoidal surgery : postoperative external lumbar drainage reduces the risk for meningitis 显示文摘 | Van Aken MO Feelders R A de Marie S | 2005 | Pituitary2005，7，2： | 1 |
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