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| 1 | Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found between the two groups on the Physicochemical indexes(all P >0.05). No adverse events or reactions occurred in the experimental groups.CONCLUSION: Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients. | Yang Yan Lu Yao Zhou Deping Pei Fenglan Li Qin Chen Shuqiong Wang Qiufeng Wang Yanting Jin Zhe Liu Yanxia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 2 | Occurrence and light response of residual plastid genes in a Euglena gracilis bleached mutant strain OflB2显示文摘Euglena gracilis is a unicellular green eukaryotic microalga that features characteristics of both plants and animals.The photosynthetic function of its chloroplast is easily lost under stress resulting in bleached mutants,while the physiological role of their residual plastid DNAs remains unclear.In this study,we obtained five bleached mutants by ofloxacin(Ofl)treatment,identified 12 residual plastid genes in five bleached mutants,and determined the mRNA levels in the wild type E.gracilis(WT)and one bleached mutant(OflB2)under dark and light stimulation conditions by quantitative reverse transcribed PCR(qRTPCR).Results show that the expression of all selected plastid genes in both WT and OflB2 mutant did not change significantly in darkness,while their responses to light stimulation were different.Under the light stimulation conditions,half of the genes did not change significantly,while most of the other genes were down-regulated in OflB2 mutant and up-regulated in WT.Therefore,the bleached mutant retains part of the plastid genome and the plastid relic is responsive to light.Our research will help to understand the functions of residual plastid DNA and evolution of chloroplasts. | QIN Huan GUO Qingqing LIU Chenchen LI Fenglan ZHANG Hua CHU Zihan WANG Jiangxin LEI Anping | 2020 | Journal of Oceanology and Limnology2020，38，6： | 0 |
| 3 | Effects of Distiller's Grain Substrate with Acid Regulation on the Growth of Tobacco Seedlings in Floating Breeding System显示文摘In order to reduce the use of peat resources and realize the sustainable development of tobacco,the pH of distiller's grain substrate was adjusted with humic acid,and the effects of various distiller's grain substrates on the growth of tobacco seedlings were studied to find out the method of cultivating high-quality tobacco seedlings by using distiller's grain substrate. The results showed that when 60% of humic acid was added to the distiller's grain substrate made from coarse distiller's grains,fine distiller's grains,perlite and vermiculite,both the pH and electrical conductivity decreased significantly and were similar to that of the conventional substrate. Moreover,the emergence rate of tobacco seedlings,the rate of strong tobacco seedlings,leaf number,stem height,root growth and quality of tobacco seedlings were good. | Sheng JIANG Sang HU Fei XIONG Yonghui ZHANG Chun XIA Zilin LI Yongyu ZHAO Guangming TANG Fenglan QIN Qixin GU Jinchao ZHAO Junfeng XIN Fuzhao NIAN | 2018 | Agricultural Biotechnology2018，7，4： | 0 |
| 4 | Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides显示文摘An atroposelectively diversity-oriented synthetic strategy was developed for the divergent synthesis of axially chiral heterocycles through organocatalytic asymmetric intramolecular annulation of alkyne via vinylidene ortho-quinone methides(VQMs).The methodology reported herein was characterized by rapid reactions(most completed in seconds),high stereocontrol(up to 98%ee),and broad substrate scope(60 examples of different skeletal types,stereogenicelements,andring sizes). | Da Xu Shengli Huang Fangli Hu Lei Peng Shiqi Jia Hui Mao Xiangnan Gong Fenglan Li Wenling Qin Hailong Yan | 2022 | CCS Chemistry2022，4，8： | 0 |
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